SCL/Tal-1 expression in T-acute lymphoblastic leukemia: An immunohistochemical and genotypic study

Human Pathology

Volumn 26, Issue 9, 1995, Pages 994-998

  Chetty, Runjan ^{a,b,c,d,e,f,g}   Pulford, Karen ^{a,b,c,d,e,f,g}   Jones, Margaret ^{a,b,c,d,e,f,g}   Mathieu Mahul, Daniele ^{a,b,c,d,e,f,g}   Close, Pauline ^{a,b,c,d,e,f,g}   Hussein, Sonay ^{a,b,c,d,e,f,g}   Pallesen, Gorm ^{a,b,c,d,e,f,g}   Ralfkiaer, Elizabeth ^{a,b,c,d,e,f,g}   Stein, Harald ^{a,b,c,d,e,f,g}   Gatter, Kevin ^{a,b,c,d,e,f,g}   Mason, David ^{a,b,c,d,e,f,g}  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d ROYAL MELBOURNE HOSPITAL   (Australia)

^e University Institute of Pathology Arhus   (Denmark)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

^g FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

immunohistochemistry; polymerase chain reaction; SCL TAL 1; T acute lymphoblastic leukemia

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; GENE DELETION; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEUKEMOGENESIS; POLYMERASE CHAIN REACTION; T CELL LEUKEMIA;

BASE SEQUENCE; COMPARATIVE STUDY; DNA-BINDING PROTEINS; GENE DELETION; GENOTYPE; HUMAN; IMMUNOHISTOCHEMISTRY; LEUKEMIA, T-CELL, ACUTE; MOLECULAR PROBES; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS;

EID: 0029150549     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/0046-8177(95)90089-6     Document Type: Article

References (22)

1. Chromosomal translocation in a human leukemic stem-cell line disrupts the human T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript
2. Involvement of the TCL-5 gene on human chromosome 1 in T-cell leukemia and melanoma
3. The tal gene undergoes translocation in T-cell leukemia and potentially encodes a helix-loop-helix protein
4. Disruption of the SCL locus in T-lymphoid malignancies correlates with committment to the T-cell receptor αβ lineage
5. Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia
6. Expression of tal-1 and GATA-binding priteins during hematopoiesis
7. Single step purification of polypeptides expressed in Escherichia coli transferase
8. A 72kD B-cell associated surface glycoprotein is expressed at high levels in hairy cell leukaemia and plasma cell neoplasms
9. Expression of the tal-1 proteins in human tissues
10. The 14;18 translocation in European cases of follicular lymphoma: Comparison of Southern blotting and the polymerase chain reaction
11. Sil-tal 1 deletion in T-cell acute lymphoblastic leukaemia
12. The SCL/tal-1 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis
13. Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia
14. two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupts the 5′ part of the tal-1 gene
15. Rearrangements of the tal-1 locus as clonal markers for T cell acute lymphpblastic leukemia
16. Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T-cell receptor αβ lineage: T-cell receptor δ gene deletion mechanism affects multiple genes
17. Characterization of translocation t(1;14) (p32;q11) in a T and in a B acute leukemia
18. SCL is coexpressed with GATA-1 in hemopoietic cells but is also expressed in developing brain
19. T-cell acute lymphoblastic leukemia: The associated gene SCL/tal codes for a 42kD nuclear phosphoprotein
20. Expression of the SCI/ TAL-1 gene is common in T-ALL in the absence of any detectable disruption of the gene
21. Expression of the bcl-2 protein is not specific for the 14;18 translocation
22. T-cell acute lymphoblastic leukemia and the associated basic helix-loop-helix gene SCL/tal