Supplementation with Selenium Restores Age-Related Decline in Immune Cell Function

Proceedings of the Society for Experimental Biology and Medicine

Volumn 209, Issue 4, 1995, Pages 369-375

  Roy, M ^a   Kiremidjian Schumacher, L ^b   Wishe, H I ^b   Cohen, M W ^b   Stotzky, G ^c  

^a Basic Science Division   (United States)

^b NEW YORK UNIVERSITY COLLEGE OF DENTISTRY   (United States)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; DNA; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; MITOGENIC AGENT; PHYTOHEMAGGLUTININ; SELENIUM; SODIUM SELENITE;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL KILLING; CONTROLLED STUDY; CYTOTOXIC LYMPHOCYTE; CYTOTOXICITY; DIET SUPPLEMENTATION; DNA SYNTHESIS; EFFECTOR CELL; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE TRANSFORMATION; MALE; MOUSE; NONHUMAN; T LYMPHOCYTE ACTIVATION;

AGING; ANIMAL; CYTOTOXICITY, IMMUNOLOGIC; DNA; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; PHYTOHEMAGGLUTININS; SELENIUM; SPLEEN; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED;

EID: 0029150350     PISSN: 00379727     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/00379727-209-43909     Document Type: Article

References (32)

1. Hirokawa K. Understanding the mechanism of the age-related decline in immune function. Nutr Rev 50:361–366, 1992.
2. Proust JJ, Filburn SA, Harrison SA, Buchholz MA, Nordin AA. Age-related defect in signal transduction during lectin activation of murine T lymphocytes. J Immunol 139:1472–1478, 1987.
3. Miller RA, Jacobson B, Weil G, Simons ER. Diminished calcium influx in lectin-activated T cells from old mice. J Cell Physiol 132:337–342, 1987.
4. Negoro S, Hara H, Miyata S, Saiki O, Tanaka K, Yoshizaki K, Igarashi T, Kishimoto S. Mechanisms of age-related decline in antigen-specific T cell proliferative response: IL-2 receptor expression and recombinant IL-2 induced proliferative response of purified TAC-positive T cells. Mech Ageing Devel 36:223–241, 1986.
5. Hara H, Tanaka T, Negoro S, Deguchi Y, Nishio S, Saiki O, Kishimoto S. Age-related changes of expression of IL-2 receptor subunits and kinetics of IL-2 internalization in T cells after mitogenic stimulation. Mech Ageing Devel 45:167–175, 1988.
6. Staiano-Coico L, Darzynkiewicz Z, Melamed MR, Weksler ME. Immunological studies of aging. IX. Impaired proliferation of T lymphocytes detected in elderly humans by flow cytometry. J Immunol 132:1788–1792, 1984.
7. Miller RA, Stutman O. Decline, in aging mice, of the anti-2,4,6,-trinitrophenyl (TNP) cytotoxic T cell response attributable to loss of Lyt-2-, interleukin 2-producing helper cell function. Eur J Immunol 11:751–756, 1981.
8. DePaoli P, Battistin S, Santini GF. Age-related changes in human lymphocyte subsets: Progressive reduction of the CD4 CD45R (suppressor inducer) population. Clin Immunol Immu-nopath 48:290–296, 1988.
9. Meydani SN, Yogeeswaran G, Liu S, Baskar S, Meydani M. Fish oil and tocopherol-induced changes in natural killer cell-mediated cytotoxicity and PGE2 synthesis in young and old mice. J Nutr 118:1245–1252, 1988.
10. Bubenik J, Cinader B, Indrova M, Koh SW, Chou C-T. Lym-phokine-activated killer (LAK) cells: I. Age-dependent decline of LAK cell-mediated cytotoxicity. Immunol Lett 16:113–119, 1987.
11. Kiremidjian-Schumacher L, Stotzky G. Selenium and immune responses. A review. Environ Res 42:277–303, 1987.
12. Kiremidjian-Schumacher L, Roy M, Wishe HI, Cohen MW, Stotzky G. Selenium and immune cell functions. I. Effect on lymphocyte proliferation and production of interleukin-1 and interleukin-2. Proc Soc Exp Biol Med 193:136–142, 1990.
13. Roy M, Kiremidjian-Schumacher L, Wishe HI, Cohen MW, Stotzky G. Selenium and immune cell functions. II. Effect on lymphocyte-mediated cytotoxicity. Proc Soc Exp Biol Med 193:143–148, 1990.
14. Kiremidjian-Schumacher L, Roy M, Wishe HI, Cohen MW, Stotzky G. Regulation of cellular immune responses by selenium. Biol Trace Elem Res 33:23–35, 1992.
15. Roy M, Kiremidjian-Schumacher L, Wishe HI, Cohen MW, Stotzky G. Supplementation with selenium and human immune cell functions. I. Effect on lymphocyte proliferation and interleukin 2 receptor expression. Biol Trace Elem Res 41:103–114, 1994.
16. Roy M, Kiremidjian-Schumacher L, Wishe HI, Cohen MW, Stotzky G. Effect of selenium on the expression of high affinity interleukin 2 receptors. Proc Soc Exp Biol Med 200:36–43, 1992.
17. Roy M, Kiremidjian-Schumacher L, Wishe HI, Cohen MW, Stotzky G. Selenium supplementation enhances the expression of interleukin 2 receptor subunits and internalization of interleukin 2. Proc Soc Exp Biol Med 202:295–301, 1993.
18. Spallholz JE, Collins GF, Schwartz K. A single-test-tube method for the fluorometric determination of selenium. Bio-inorg Chem 9:453–459, 1978.
19. Dickstein R, Kiremidjian-Schumacher L, Stotzky G. Effects of lidocaine on the function of immunocompetent cells. II. Chronic in vivo exposure and its effects on mouse lymphocyte activation and expression of immunity. Immunopharmacology 9:127–139, 1985.
20. Kiremidjian-Schumacher L, Roy M, Wishe HI, Cohen MW, Stotzky G. Supplementation with selenium and human immune cell functions. II. Effect on cytotoxic lymphocytes and natural killer cells. Biol Trace Elem Res 41:115–127, 1994.
21. Bol SJ, Rosdorff HJ, Ronteltap CP, Hennen LA. Cellular cytotoxicity assessed by the 51Cr release assay. Biological interpretation of mathematical parameters. J Immunol Methods 90:15–23, 1986.
22. Ullman KS, Northrop JP, Verwej CL, Crabtree GR. Transmission of signals from the lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: The missing link. Annu Rev Immunol 8:421–452, 1990.
23. Bloom ET, Horvath JA. Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T cell activity. J Immunol 152:4242–4254, 1994.
24. Grabstein KH, Eienman J, Shanebeck K, Rauch C, Srinvasan S, Fung V, Beers C, Richardson J, Schoenborn MA, Ahdieh M, Johson L, Alderson MR, Watson JD, Anderson DM, Giri JG. Cloning of a T cell growth factor that interacts with the B chain if the interleukin-2 receptor. Science 264:965–968, 1994.
25. Crabtree GR. Contingent genetic regulatory events in T lymphocyte activation. Science 243:355–361, 1989.
26. Cantrell DA, Smith KA. The interleukin-2 T cell system: A new cell growth model. Science 224:1312–1316, 1984.
27. Miller RA. Age-associated decline in precursor frequency for different T cell-mediated reactions, with preservation of helper or cytotoxic effect per precursor cell. J Immunol 132:63–68, 1984.
28. Fong TC, Makinodan T. In situ hybridization analysis of the age associated decline in IL-2 mRNA expressing murine T cells. Cell Immunol 118:199–207, 1989.
29. Gilman SC, Rosenberg JS, Feldman JD. T lymphocytes from young and aged rats. II. Functional defects and the role of in-terleukin-2. J Immunol 128:644–650, 1982.
30. Rabinowich H, Goses Y, Reshef T, Klajman A. Interleukin-2 production and activity in aged humans. Mech Ageing Devel 32:213–226, 1985.
31. Proust JJ, Kittur DS, Buchholz M, Nordin AA. Restricted expression of mitogen-induced high affinity IL-2 receptors in aging mice. J Immunol 141:4209–4216, 1988.
32. Kiremidjian-Schumacher L, Roy M, Wishe HI, Cohen MW, Stotzky G. Effect of selenium supplementation on macrophage-mediated tumor cytodestruction. J Nutr Immunol 1:65–79, 1991.