Characterization of inducible nitric oxide synthase expression in endotoxernic rat cardiac myocytes in vivo and following cytokine exposure in vitro

Journal of Molecular and Cellular Cardiology

Volumn 27, Issue 9, 1995, Pages 2015-2029

  Luss, Hartmut ^a   Watkins, Simon C ^a   Freeswick, Paul D ^a   Imro, Amy K ^a   Nussler, Andreas K ^a   Billiar, Timothy R ^a   Simmons, Richard L ^a   Del Nido, Pedro J ^a   McGowan Jr , Francis X ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

in situ hybridization; Interferon ; Interleukin 1 ; Lipopolysaccharide; Nitric oxide; Northern blot; Tumor necrosis factor

Indexed keywords

CYTOKINE; DEXAMETHASONE; GAMMA INTERFERON; GLUCOSE; HEART ENZYME; INTERLEUKIN 1BETA; LACTIC ACID; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME ACTIVITY; ENZYME INDUCTION; GLUCOSE TRANSPORT; HEART CELL CULTURE; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART MUSCLE METABOLISM; IN SITU HYBRIDIZATION; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT; VASCULAR SMOOTH MUSCLE;

ANIMAL; CELLS, CULTURED; HEART VENTRICLE; IN SITU HYBRIDIZATION; INTERFERON TYPE II; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MALE; NITRIC-OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR NECROSIS FACTOR;

EID: 0029148994     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-2828(95)90023-3     Document Type: Article

References (65)

1. Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium
2. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide
3. Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia
4. Isolation of nitric oxide synthetase. a calmodulin-requiring enzyme
5. Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells
6. Single step method of RNA isolation by acid guanidiniurn thiocyanatephenol-chloroform extraction
7. Isolation and culture of the terminally differentiated adult mamallian cardiac muscle cell
8. Culture of the terminally differentiated adult cardiac muscle cell: a light and scanning electron microscope study
9. Cardiac transplantation: immune mechanisms and alloantigens involved in allograft rejection
10. Nitric oxide synthase activities in human myocardium
11. Murine cytotoxic activated macrophages inhibit aconitase in tumor cells: inhibition involves the iron-sulfur prosthetic group and is reversible
12. Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages
13. Interleukin-1β modulates myocardial contraction via dexarnethasone sensitive production of nitric oxide
14. Negative inotropic effects of cytokines on the heart mediated by nitric oxide
15. Differential induction of nitric oxide synthase in hepatocytes during endotoxemia and the acute-phase response
16. Cytokines. endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes
17. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes
18. 15N] nitrate in biological fluids
19. Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness
20. 31P-NMR studies of isolated adult heart cells: effect of myoglobin inactivation
21. Attachment and maintenance of adult rabbit cardiac myocytes in primary cell culture
22. Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated injury
23. Induction of cytokine release from human monocytes by Coxsackievirus infection
24. Evidence for cytokineinducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy
25. Cellular mechanisms of endotoxin-induced myocardial depression in rabbits
26. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages
27. Endothelial cell production of nitrogen oxides in response to interferon in combination with tumor necrosis factor
28. G-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric oxide
29. Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation
30. EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages
31. Role of IL-1 and tumor necrosis factor in Coxsackie virus-induced autoimmune myocarditis
32. Interleukin-1 or tumor necrosis factor can promote Coxsackie B3-induced myocarditis in resistant B10 A mice
33. LPS promotes CB3-induced myocarditis in resistant B10 A mice
34. Cardiorespiratory effects of immunotherapy with interleukin-1
35. Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA
36. Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme
37. Macrophage nitric oxide synthase gene. Two upsteam regions mediate induction by interferon y and lipopolysaccharide
38. Protein measurement with the Folin phenol reagent
39. Tyrosine kinase inhibitors suppress endotoxin- and IL1 b-induced NO synthesis in aortic smooth muscle cells
40. Macrophage oxidation of L-anginine to nitrate and nitrite: nitric oxide is an intermediate
41. Response of man to endotoxin
42. Interleukin-1 α preconditioning reduces myocardial ischelnia-reperfusion injury
43. Myocardial effects of interleukin-2
44. The L-arginine-nitric oxide pathway
45. New insights into the regulation of inducible nitric oxide synthesis
46. Substrate use in Eschemic and reperfused myocardium quantitative considerations
47. Cytokines and lipopolysaccharide induce nitric oxide synthase in cultured rat pulmonary artery smooth muscle
48. Inflammation, immunoregulation and inducible nitric oxide synthase
49. Induction of NIn-superoxide disinutase by tumor necrosis factor, interleukin-1, and interleukin-6 in human hepatoma cells
50. Left ventricular systolic and diastolic dysfunction after infusion of tumor necrosis factor-α in conscious dogs
51. The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids
52. Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality
53. Glucocorticoids inhibit the expression of an inducible, not not the constitutive, nitric oxide synthase in vascular endothelial cells
54. Gene expression in visceral endoderm: a comparison of mutant and Wild-type F9 embryonal carcinoma cell differentiation
55. 2+)-independent nitric oxide synthase in the myocardium
56. Porcine ventricular endocardial cells in culture express the inducible form of nitric oxide synthase
57. Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes
58. Nitric oxide: a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
59. Myoglobindependent oxidative metabolism in the hypoxic rat heart
60. Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide
61. Cytokine gene expression in rejecting cardiac allografts
62. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages