The protein kinase C and protein kinase C related gene families

Current Opinion in Structural Biology

Volumn 5, Issue 3, 1995, Pages 396-402

  Dekker, Lodewijk V ^a   Palmer, Ruth H ^a   Parker, Peter J ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID; PHORBOL; PROTEIN KINASE C;

BINDING SITE; CATALYSIS; ENZYME ACTIVATION; MULTIGENE FAMILY; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN TERTIARY STRUCTURE; REVIEW; SECOND MESSENGER; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMAL; HUMAN; MOLECULAR SEQUENCE DATA; PROTEIN KINASE C; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS;

EID: 0029147429     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-440X(95)80103-0     Document Type: Article

References (35)

1. Intracellular signalling by hydrolysis of phospholipids and activiation of protein kinase C
2. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters
3. Identification of multiple, novel, protein kinase C-related gene products
4. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains
5. Three protein kinase structures define a common motif
6. Intrapeptide regulation of protein kinase C
7. Requirement for negative charge on “activation loop” of protein kinase C
8. Identification of the phosphorylated region responsible for the permissive activation of PKC
9. Threonine-497 is a critical site for permissive activation of protein kinase Cα
10. In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation
11. PKCμ is a novel, atypical member of the protein-kinase-C family
12. Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with an unusual catalytic domain
13. Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family
14. Characterization of activators and inhibitors of protein kinase Cμ
15. Expression and characterization of PKD, a phorbol ester and diacylglycerol-stimulated serine protein kinase
16. Mutagenesis of the regulatory domain of rat protein C▿η — a molecular basis for restricted histone kinase activity
17. Altered substrate selectivity of PKC-η pseudosubstrate site mutants
18. A molecular mechanism for the binding of protein kinase-C to membranes
19. Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol
20. Protein kinase C V3 domain mutants with differential sensitivities to m-calpain are not resistant to phorbol-ester-induced down-regulation
21. Kinetic evidence that 1,2-diolein inhibits phorbol ester binding to protein kianse-C via a competitive mechanism
22. Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence
23. Identification and characterization of zinc binding sites in protein kinase C
24. The regulatory domain of protein kinase C coordinates four atoms of zinc
25. The regulatory region of protein kinase γ
26. Solution structure of a cysteine rich domain of rat protein kinase C
27. Zinc finger domains and phorbol ester pharmacophore
28. Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor
29. Close similarity of baculovirus-expressed n-chimaerin and protein kinase Cα as phorbol ester receptors
30. Calcium-dependent activation of protein kinase C — the role of the c2 domain in divalent cation selectivity
31. 2+-dependent translocation domain with homology to PKC and GAP
32. 2+/phospholipid binding
33. 2+-binding domains
34. Doc2: a novel brain protein having two repeated C2-like domains
35. 2+.phospholipid-binding fold