Structural and functional relationships of heterotrimeric G-proteins

FASEB Journal

Volumn 9, Issue 11, 1995, Pages 1059-1066

  Rens Domiano, Stephanie ^a   Hamm, Heidi E ^a,b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

Author keywords

effector; GTPase; receptor; signal transduction

Indexed keywords

CELL SURFACE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE;

BETA CHAIN; EFFECTOR CELL; ENZYME ACTIVITY; ENZYME REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

EID: 0029145416     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.9.11.7649405     Document Type: Review

References (62)

1. Noel, J., Hamm, H. E., and Sigler, P.A. (1993) The crystal structure of the GTPγS-bound alpha subunit of the rod G-protein. Nature 366, 654-663
2. Lambright, D. G., Noel, J. P., Hamm, H. E., and Sigler, P. B. (1994) The 1.8A crystal structure of transducin α-GDP: Structural determinants for activation of a heterotrimeric G-protein α subunit. Nature 369, 621-628
3. -. Nature 372, 276-279
4. 1 and the mechanism of CTP hydrolysis. Science 265, 1405-1412
5. Clapham, D. E., and Neer, E. J. (1993) New roles for G-protein βγ dimers in transmembrane signalling. Nature 365, 403-406
6. Simon, M. I., Stralhmann, M. P., and Gautam, N. (1991) Diversity of G-proteins in signal transduction. Science 252, 802-808
7. Hepler, J. R., and Gilman, A. G. (1992) G-proteins. Trends Biochem. Sci. 17, 383-387
8. βγ, receptors and effectors. Cell 73, 631-641
9. z. Mol. Cell. Endocrinol. 100, 71-74
10. Watson, A. J., Katz, A., and Simon, M. I. (1994) A fifth member of the mammalian G-protein β-subunit family. J. Biol. Chem. 269, 22150-22156
11. Kokame, K., Fukada, Y., Yoshizawa, T., Takao, T., and Shimonishi, Y. (1992) Lipid modification at the N terminus of photoreceptor G-protein α-subunit. Nature 359, 749-752
12. Linder, M. E., Middleton, P., Hepler, J. R., Taussig, R., Gilman, A. G., and Mumby, S. M. (1993) Lipid modification of G-proteins: α subunits are palmitoylated. Proc. Natl. Acad. Sci. USA 90, 3675-3679.
13. West, R. E., Moss, J., Vaughan, M., Lui, T., and Lin, T. Y. (1985) Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine-347 is the ADP ribose acceptor site. J. Biol. Chem. 260, 14428-14430
14. Masters, S. B., Stroud, R. M., and Bourn, H. R. (1986) Family of G-protein α chains: amphipathic analysis and predicted structure of functional domains. Prot. Engin. 1, 47-54
15. αt: more to view than just ras. Cell 76, 201-204
16. sα alter stimulation of adenylyl cyclase. J. Biol. Chem. 264, 15467-15474
17. sα. J. Biol. Chem. 264, 15475-15482
18. Lupas, A. N., Lupas, J. M., and Stock, J. B. (1992) Do C-protein subunits associate via a three- stranded coiled coil? FEBS Lett. 314, 105-108
19. Neer, E. J. (1994) G-proteins: critical points for transmembrane signalling. Prot. Sci. 3, 3-14
20. Higgins, J. B., and Casey, P. J. (1994) In vitro processing of recombinant G-protein γ subunits. J. Biol. Chem. 269, 9067-9073
21. Wilcox, M. D., Schey, K. L., Dingus, J., Mehta, D., Tatum, B. S., Halushka, M., Finch, J. W., and Hildebrandt, J. D. (1994) Analysis of C-protein γ subunit heterogeneity using mass spectrometry. J. Biol. Chem. 269, 12508-12513
22. Schmidt, C. J., Thomas, T. C., Levine, M. A., and Neer, E. J. (1992) Specificity of G-protein β and γ subunit interaction. J.Biol Chem. 267, 13807-13810
23. Bubis, J., and Khorana, H. C. (1990) Sites of interaction in the complex between β- and γ-subunits of transducin. J.Biol. Chem. 265, 12995-12999
24. Garritsen, A., van Galen, P. J. M., and Simonds, W. F. (1993) The N-terminal coiled-coil domain of β is essential for γ association: a model for G-protein βγ subunit interaction. Proc. Natl. Acad. Sci. USA 90, 7706-7710
25. Spring, D. J., and Neer, E. J. (1994) A 14 amino acid region of the G protein γ subunit is sufficient to confer the selectivity of α binding to the β subunit. J. Biol. Chem. 269, 22882-22886
26. Fukada, Y., Matsuda, T., Kokame, K., Takao, T., Shimonishi, Y., Akino, T., and Yoshizawa, T. (1994) Effect of carboxyl methylation of photoreceptor G-protein γ-subunit in visual transduction. J. Biol. Chem. 269, 5163-5170
27. Hamm, H. E. (1991) Molecular interactions between the photoreceptor G-protein and rhodopsin. Cell Mol. Neurobiol. 11, 563-578
28. Dratz, E. D., Fursteneau, J. E., Lambert, C. G., Thireault, D. L., Rarick, H., Schepers, T., Pakhlevaniants, S., and Hamm, H. E. (1993) NMR structure of a receptor-bound G-protein peptide. Nature 363, 276-280
29. Hamm, H. E., Deretic, D., Arendt, A., Hargrave, P. A., Koenig, B., and Hoffman, K. P. (1988) Site of G-protein binding to rhodopsin mapped with synthetic peptides from the α subunit. Science 241, 832-835
30. Rasenick, M. M., Watanabe, M., Lazarevic, M. B., Hatta, S., and Hamm, H. E. (1994) Synthetic peptides as probes for G-protein function. J. Biol. Chem. 269, 21519-21528
31. iα. Nature 363, 274-276
32. Kleuss, C. J., Hescheler, C., Ewel, W., Rosenthal, G., Schultz, G., and Wittig, B. (1991) Assignment of G-protein subtypes to specific receptors inducting inhibition of calcium channels. Nature 353, 43-48.
33. De Vivo, M., and Iyengar, R. (1994) G-protein pathways: signal processing by effectors. Mol. Cell. Endocrin. 100, 65-70
34. sα specifies coupling of receptors to stimulation of adenylyl cyclase. Science 241, 448-451
35. αs chimeras define the function of α chain domains in control of G-protein activation and βγ subunit complex interactions. Cell 63, 697-706.
36. sα mutants with decreased abilty to activate adenylyl cyclase. J. Biol. Chem. 266, 16226-16231
37. sα. Cell 68, 911-922.
38. Rarick, H. M., Artemyev, N. O., and Hamm, H. E. (1992) A site on rod C-protein α subunit that mediates effector activation. Science 256, 1031-1033
39. Brown, R. L., and Stryer, L. (1989) Expression in bacteria of functional inhibitory subunit of retinal rod cGMP phosphodiesterase. Proc. Natl. Acad. Sci. USA 86, 4922-4926
40. Artemyev, N. O., and Hamm, H. E. (1992) Two-site high-affinity interaction between inhibitory and catalytic subunits of rod cyclic CMP phosphodiesterase. Biochem. J. 283, 273-279
41. Skiba, N. P., Artemyev, N. O., and Hamm, H. E. (1995) The carboxyl terminus of the γ-subunit of rod cGMP phosphodiesterase contains distinct sites of interaction with the enzyme catalytic subunits and the α-subunit of transducin. J. Biol. Chem. 270, 13210-13215
42. Artemyev, N. O., Mills, J. S., Thornburg, K. R., Knapp, D. R., Schey, K. L., and Hamm, H. E. (1993) A site on transducin α-subunit of interaction with the polycationic region of cGMP phosophodiesterase inhibitory subunit. J. Biol. Chem. 268, 23611-23615
43. 0 subunit, mutation of conserved cysteines identifies a subunit contact surface and alters CDP affinity. Proc. Natl. Acad. Sci. USA 90, 10295-10298
44. Whiteway, M., Clark, K. L., Leberer, E., Dignard, D., and Thomas, D. Y. (1994) Genetic identification of residues involved in association of alpha and beta G-protein subunits. Mol. Cell. Biol. 14, 3223-3229
45. +, a photoactivatable probe for G-protein structure: evidence for holotransducin oligomers in which the ADP-ribosylated carboxyl terminus of αt interacts with both β and γ subunits. Proc. Natl. Acad. Sci. USA 87, 3645-3649
46. Rahmatullah, M., and Robishaw, J. D. (1994) Direct interaction of the α and subunits of the G-proteins. J. Biol. Chem. 269, 3574-3580.
47. 0 protein subunits. J. Biol. Chem. 266, 3900-3906
48. Wildman, D. E., Tamir, H., Leberer, E., Northrup, J. K., and Dennis, M. (1993) Prenyl modification of guanine nucleotide regulatory protein γ2 subunits is not required for interaction with the transducin α subunit or rhodopsin. Proc. Natl. Acad. Sci. USA 90, 794-798
49. Crespo, P., Xu, N., Simonds, W. F., and Gutkin, J. S. (1994) Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits. Nature 369, 418-420
50. Thomason, P. A., James, S. R., Casey, P. J., and Downes, C. P. (1994) A G-protein βγ-subunit responsive phosphoinositide 3-kinase activity in human platelet cytosol. J. Biol. Chem. 269, 16525-16528
51. Iniguez-Lluhi, J. A., Simon, M. I., Robishaw, J. D., and Gilman, A. F. (1992) G-protein βγ subunits synthesized in Sf9 cells. J. Biol. Chem. 267, 23409-23417
52. Leberer, E., Dignard, D., Hougan, L., Thomas, D. Y., and Whiteway, M. (1992) Molecular characterization of SIGI, a Saccharomyces cerevisiae gene involved in negative regulation of G-protein-mediated signal transduction, EMBO J. 11, 4805-4813
53. + channel. Proc. Natl. Acad. Sci. USA 85, 5815-5818
54. Kelleher, D. J., and Johnson, G. L. (1988) Transducin inhibition of light dependent rhodopsin phosphorylation. Evidence for βγ subunit interaction with rhodopsin. Mol. Pharm. 34, 452-460;
55. Phillips, W. J., and Cerione, R. A. (1992) Rhodopsin/transducin interactions. I. Characterization of the binding of the transducin-βγ subunit complex to rhodopsin usingfluorescence spectroscopy. J. Biol. Chem. 267, 17032-17039
56. Kisselev, O., and Gautam, N. (1993) Specific interaction with rhodopsin is dependent on the γ subunit type in a G-protein. J. Biol. Chem. 268, 24519-24522;
57. Haga, K., and Haga, T. (1992) Activation by G protein βγ subunits of agonist-or light dependent phosphorylation of muscarinic acetylcholine receptors and rhodopsin. J. Biol. Chem. 267, 2222-2227
58. Pitcher, J. A., Inglese, J., Higgins, J. B., Arriza, J. L., Casey, P. J., Kim, C., Benovic, J. L., Kwatra, M. M., Caron, M. G., and Lefkowitz, R. J. (1992) Role of βγ subunits of G-proteins in targeting the β-adrenergic receptor kinase to membrane bound receptors. Science 257, 1264-1367
59. Haga, K., Kameyama, K., and Haga, T. (1994) Synergistic activation of a G-protein-coupled receptor kinase by G-protein βγ subunits and mastoparan or related peptides. J. Biol. Chem. 269, 12594-12599
60. Koch, W. J., Inglese, J., Stone, W. C., and Lefkowitz, R. J. (1993) The binding site for the βγ subunits of heterotrimeric G-proteins on the β-adrenergic receptor kinase. J. Biol. Chem. 268, 8256-8260
61. Shaw, G. (1993) Identification of novel pleckstrin homology (PH) domains provides a hypothesis for PH domain function, Biochem. Biophys. Res. Commun. 195, 1145-1151
62. Musacchio, A., Gibson, T., Rice, P., Thompson, J., and Saraste, M. (1993) The PH domain: a common piece in the structural patchwork of signalling proteins. Trends Biol. Sci. 18, 343-340