Addition of immunotherapy with Mycobacterium w vaccine to multi-drug therapy benefits multibacillary leprosy patients

Vaccine

Volumn 13, Issue 12, 1995, Pages 1102-1110

  Zaheer, S A ^a   Beena, K R ^a   Kar, H K ^b   Sharma, A K ^b   Misra, R S ^c   Mukherjee, A ^d   Mukherjee, R ^a   Kaur, H ^a   Pandey, R M ^a   Walia, R ^a   Mukhopadhyay, A ^a   Talwar, G P ^e  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^b DR RAM MANOHAR LOHIA HOSPITAL   (India)

^c SAFDARJUNG HOSPITAL   (India)

^d SAFDARJUNG HOSPITAL CAMPUS   (India)

^e NONE

Author keywords

bacteriological clearance; Combined chemotherapy and immunotherapy; double blind; histological upgrading; lepromin conversion; release from treatment (RFT)

Indexed keywords

CLOFAZIMINE; DAPSONE; LEPROMIN; MYCOBACTERIUM VACCINE; RIFAMPICIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HUMAN; IMMUNOTHERAPY; INTRADERMAL DRUG ADMINISTRATION; LEPROSY; MAJOR CLINICAL STUDY; MYCOBACTERIUM LEPRAE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VACCINATION;

BACTERIAL VACCINES; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; HUMANS; LEPROMIN; LEPROSY; LYMPHOCYTES; MYCOBACTERIUM;

EID: 0029145323     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0264-410X(94)00033-J     Document Type: Article

References (41)

1. WHO Expert Committee on leprosy. Sixth report
2. The disease
3. Immunology of human leprosy. Current status
4. Bacteriological study of a rapidly growing strain of mycobacterium
5. A report on the biochemical analysis of Mycobacterium w
6. Five cultivable mycobacterial strains giving blast transformations and leukocyte migration-inhibition of leukocytes analogous to Mycobacterium leprae
7. Delayed hypersensitivity skin reactions to homologous and heterologous antigens in guinea pigs immunized with M. leprae and four selected cultivable mycobacterial strains
8. Local reactions to intra-dermal instillation of Mycobacterium w and ICRC bacilli in mice
9. Enlargement of draining lymph nodes in mice by four selected cultivable strains of mycobacteria
10. Early and late reactions in tuberculoid and lepromatous leprosy patients with lepromins from Mycobacterium leprae and five selected cultivable mycobacteria
11. Molecular definition of unique species status of Mycobacterium w; a candidate leprosy vaccine strain
12. Lepromin conversion in repeatedly lepromin negative BL/LL patients after immunization with autoclaved Mycobacterium w
13. Immunotherapeutic effects of a vaccine based on a saprophytic cultivable mycobacterium, Mycobacterium w, in multibacillary leprosy patients
14. Present approaches to immunotherapy and immunoprophylaxis in leprosy
15. Immunotherapeutic trials with a candidate anti-leprosy vaccine based on Mycobacterium w
16. Histopathological monitoring of immunotherapeutic trials with Mycobacterium w
17. Immunological upgrading with combined immunotherapy and chemotherapy in an LL patient. A case report
18. Immunotherapy with Mycobacterium w vaccine decreases the incidence and severity of type 2 (EHL) reactions
19. Combined multidrug and Mycobacterium w vaccine therapy in patients with multibacillary leprosy
20. Induction of lepromin positivity by a candidate anti-leprosy vaccine Mycobacterium w in lepromin negative healthy contacts of multibacillary leprosy patients
21. Immunotherapeutic trials using BCG and Mycobacterium strain w along with MDT in highly bacillated BL/LL cases
22. Histological changes with combined chemotherapy and immunotherapy in highly bacillated lepramatous leprosy
23. Field trials on the use of Mycobacterium w vaccine in conjunction with multidrug therapy in leprosy patients for immunotherapeutic and immunoprophylactic purposes
24. The relevance of future leprosy vaccines to disease control
25. Erythema nodosum leprosum, a clinical manifestation of the Arthus phenomenon
26. Treatment of leprosy
27. Towards development of a vaccine against leprosy
28. Immunotherapy with a mixture of Mycobacterium leprae and BCG in different forms of leprosy and in Mitsuda negative contacts
29. Anti-leprosy potentials of the ICRC vaccine: a study in patients and healthy volunteers
30. Mycobacterium vaccae in immunoprophylaxis and immunotherapy of leprosy and tuberculosis
31. Effect of multiple interferon gamma injections on the disposal of Mycobacterium leprae
32. The systemic influence of recombinant interleukin 2 on the manifestations of lepromatous leprosy
33. A follow up study of borderline tuberculoid leprosy under sulphone monotherapy
34. A comparison of low and conventional dosages of dapsone in the treatment of lepromatous leprosy in India
35. Recent developments in the field of multidrug therapy and future research in chemotherapy of leprosy
36. Immunoblot analysis of antigens of Mycobacterium w. A candidate anti-leprosy vaccine using monoclonal antibodies and patients sera
37. Identification of T cell activating recombinant antigens shared among three candidate anti-leprosy vaccines, killed M. leprae, M. bovis BCG and Mycobacterium w
38. T cell responses to fractionated antigens of Mycobacterium w, a candidate anti-leprosy vaccine, in leprosy patients
39. In vitro characteristics of T cells from Mycobacterium w vaccinated mice
40. 37 Rv in mice of different inbred strains following immunization with a leprosy vaccine based on Mycobacterium w
41. Effect of interferon gamma on hydrogen peroxide releasing capacity of monocytes derived macrophages from patients with lepromatous leprosy