Tyrosine kinase inhibitor suppresses coronary arteriosclerotic changes and vasospastic responses induced by chronic treatment with interleukin-1β in pigs in vivo

Journal of Clinical Investigation

Volumn 96, Issue 3, 1995, Pages 1288-1294

  Ito, Akira ^a   Shimokawa, Hiroaki ^a   Kadokami, Toshiaki ^a   Fukumoto, Yoshihiro ^b   Owada, M Koji ^c   Shiraishi, Tadayoshi ^a   Nakaike, Ryuichi ^a   Takayanagi, Tsuneo ^a   Egashira, Kensuke ^a   Takeshita, Akira ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^c KANEKA CORPORATION   (Japan)

Author keywords

coronary vasospasm; cytokine; growth factor; ST 638; tyrosine kinase

Indexed keywords

ALPHA CYANO 3 ETHOXY 4 HYDROXY 5 (PHENYLTHIOMETHYL)CINNAMAMIDE; ALPHA CYANO 4 HYDROXYCINNAMAMIDE; HISTAMINE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROSTAGLANDIN F2 ALPHA; PROTEIN TYROSINE KINASE INHIBITOR; RECOMBINANT INTERLEUKIN 1BETA; SEROTONIN; ST 494; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; DOSE RESPONSE; ENZYME INHIBITION; HISTOPATHOLOGY; IMMUNOREGULATION; INTRACARDIAC DRUG ADMINISTRATION; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SWINE; VASOCONSTRICTION; VASOSPASM;

EID: 0029144096     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118163     Document Type: Article

References (28)

1. Ross, R. 1993. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature (Lond.). 362:801-809.
2. Munro, J. M., and R. S. Cotran. 1988. Biology of disease: the pathogenesis of atherosclerosis: atherogenesis and inflammation. Lab. Invest. 58:249-261.
3. Hansosn, G. K., L. Jonasson, P. S. Seifert, and S. Stemme. 1989. Immune mechanisms in atherosclerosis. Arteriosclerosis. 9:567-578.
4. Shimokawa, H., H. Tomoike, S. Nabeyama, H. Yamamoto, H. Araki, M. Nakamura, Y. Ishii, and K. Tanaka. 1983. Coronary artery spasm induced in atherosclerotic miniature swine. Science (Wash. DC). 221:560-562.
5. Shimokawa, H., H. Tomoike, S. Nabeyama, H. Yamamoto, Y. Ishii, K. Tanaka, and M. Nakamura. 1985. Coronary artery spasm induced in miniature swine: angiographic evidence and relation to coronary atherosclerosis. Am. Heart. J. 110:300-310.
6. Egashira, K., H. Tomoike, H. Yamamoto, A. Yamada, Y. Hayashi, and M. Nakamura. 1986. Histamine-induced coronary spasm in regions of intimal thickening in miniature pigs: roles of serum cholesterol and spontaneous or induced intimal thickening. Circulation. 74:826-837.
7. Ito, A., H. Shimokawa, R. Nakaike, M. Sakata, T. Takayanagi, and A. Takeshita. 1993. Chronic treatment with interleukin-1β causes vasospastic response to autacoids in porcine coronary arteries in vivo. Circulation. 88(Suppl. I): I-374.
8. Ross, R., J. Glomset, B. Kariya, and L. Harker. 1974. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc. Natl. Acad. Sci. USA. 71:1207-1210.
9. Winkles, J. A., R. Friesel, W. H. Burgess, R. Howk, T. Mehlman, R. Weinstein, and T. Maciag. 1987. Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor). Proc. Natl. Acad. Sci. USA. 84:7124-7128.
10. Banskota, N. K., R. Taub, K. Zellner, P. Olsen, and G. L. King. 1989. Characterization of induction of protooncogene c-myc and cellular growth in human vascular smooth muscle cells by insulin and IGF-1. Diabetes. 38:123-129.
11. Ferns, G. A., E. W. Raines, K. H. Sprugel, A. S. Motani, M. A. Reidy, and R. Ross. 1991. Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Science (Wash. DC). 253:1129-1132.
12. Linder, V., and M. A. Reidy. 1991. Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor. Proc. Natl. Acad. Sci. USA. 88:3739-3743.
13. Grant, M. B., T. J. Wargovich, E. A. Ellis, S. Cabellero, M. Mansour, and C. J. Pepine. 1994. Localization of insulin-like growth factor I and inhibition of coronary smooth muscle cell growth by somatostatin analogues in human coronary smooth muscle cells. A potential treatment for restenosis? Circulation. 89:1511-1517.
14. Ross, R. 1986. The pathogenesis of atherosclerosis: an update. N. Engl. J. Med. 314:488-500.
15. Ek, B., B. Westemark, A. Wasteson, and C.-H. Heldin. 1982. Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor. Nature (Lond.). 295:419-420.
16. Hanks, S. K., A. M. Quinn, and T. Hunter. 1988. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science (Wash. DC). 241:42-52.
17. Ullrich, A., J. R. Bell, E. Y. Chen, R. Herrera, L. M. Petruzzelli, T. J. Dull, A. Gray, L. Coussens, Y.-C. Liao, M. Tsubokawa, et al. 1985. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature (Lond.). 313:756-761.
18. Shiraishi, T., T. Domoto, N. Imai, Y. Shimada, and K. Watanabe. 1987. Specific inhibitors of tyrosine-specific protein kinase, synthetic 4-hydroxycinnamamide derivaties. Biochem. Biophys. Res. Commun. 147:322-328.
19. Shiraishi, T., M. K. Owada, M. Tatsuka, T. Yamashita, K. Watanabe, and T. Kakunaga. 1987. Specific inhibitor of tyrosine-specific protein kinases: properties of 4-hydroxycinnamamide derivaties in vitro. Cancer Res. 49:2374-2378.
20. Ito, A., H. Shimokawa, R. Nakaike, T. Fukai, M. Sakata, T. Takayanagi, K. Egashira, and A. Takeshita. 1994. Role of protein kinase C-mediated pathway in the pathogenesis of coronary artery spasm in a swine model. Circulation. 90: 2425-2431.
21. Glenney, J. R., W. S. Chen, C. S. Lazar, G. M. Walton, L. M. Zokas, M. G. Rosenfeld, and G. N. Gill. 1988. Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of antiphosphotyrosine antibodies. J. Clin. Invest. 82:675-684.
22. Owada, M. K., M. Iwamoto, T. Koike, and Y. Kato. 1989. Effects of vanadate on tyrosine phosphorylation and the pattern on tyrosine phosphorylation and the pattern of glycosaminoglycan synthesis in rabbit chondrocytes in culture. J. Cell. Physiol. 138:484-492.
23. Dinarello, C. A. 1988. Biology of interleukin-1. FASEB (Fed. Am. Soc. Exp. Biol.) J. 2:108-115.
24. Moyer, C. F., D. Sajuthi, H. Tulli, and J. K. Williams. 1991. Synthesis of IL-1 alpha and IL-1 beta by arterial cells in atherosclerosis. Am. J. Pathol. 138:951-960.
25. Libby, P., S. J. C. Warner, G. Friedman. 1988. Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids. J. Clin. Invest. 81:487-498.
26. Ikeda, U., M. Ikeda, T. Oohara, S. Kano, T. Yaginuma. 1990. Mitogenic action of interleukin-1 on vascular smooth muscle cells mediated by PDGF. Atherosclerosis. 84:183-188.
27. Di Salvo, J., A. Steusloff, L. Semenchuk, S. Satoh, K. Kolquist, and G. Pfitzer. 1993. Tyrosine kinase inhibitors suppress agonist-induced contraction in smooth muscle. Biochem. Biophys. Res. Commun. 190:968-974.
28. Kadokami, T., H. Shimokawa, A. Ito, Y. Fukumoto, T. Takayanagi, and K. Egashira. 1994. Activation of protein kinase C induces coronary vasospasm at the interlrukin-1β-induced inflammatory/proliferative lesion in a swine model in vivo. Circulation. 90 (Suppl. I): I-258.