Evidence for a Connection between the Mismatch Repair System and the G2 Cell Cycle Checkpoint

Cancer Research

Volumn 55, Issue 17, 1995, Pages 3721-3725

  Hawn, Mary T ^a,b   Carethers, John M ^a,b   Marra, Giancarlo ^a,b   Boland, C Richard ^a,b   Koi, Minoru ^a,b,c   Umar, Asad ^c   Kunkel, Thomas A ^c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; BASE PAIRING; CANCER GROWTH; CELL CYCLE G2 PHASE; CELL DEATH; CHROMOSOME 3; COLON TUMOR; CROSS TOLERANCE; DNA REPAIR; GENE FREQUENCY; GENE MUTATION; GENETIC LINKAGE; HUMAN; HUMAN CELL; METHYLATION; PRIORITY JOURNAL;

AZAGUANINE; BASE SEQUENCE; CELL DIVISION; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA PROBES; DNA REPAIR; DNA, NEOPLASM; DRUG RESISTANCE; G2 PHASE; HUMAN; METHYLNITRONITROSOGUANIDINE; MOLECULAR SEQUENCE DATA; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THIOGUANINE; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

EID: 0029143992     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Aaltoncn, L. A., Peltomaki, P., Leach, F. S., Sistonen, P., Pylkkancn, L., Mecklin, J.-P., Jarvinen, H., Powell, S. M., Jen, J., Hamilton, S. R., Petersen, G. M., Kinzler, K. W., Vogelstein, B., and de la Chapelle, A. Clues to the pathogenesis of familial colorectal cancer. Science (Washington DC), 260: 812–816, 1993.
2. Thibodeau, S. N., Bren, G., and Schaid, D. Microsatellite instability in cancer of the proximal colon. Science (Washington DC), 260: 816–819, 1993.
3. Ionov, Y., Peinado, M. A., Malkhosyan, S., Shibata, D., and Perucho, M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature (Lond.), 363: 558–561, 1993.
4. Papadopoulos, N., Nicolaides, N. C., Wei, Y. R., Ruben, S. M., Carter, K. C., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., Adams, M. D., Venter, J. C., Hamilton, S. R., Kinzler, K. W., and Vogelstein, B. Mutation of a mutL homolog in hereditary colon cancer. Science (Washington DC), 263: 1625–1629, 1994.
5. Fishel, R., Lescoe, M. K., Rao, M. R. S., Copeland, N. G., Jenkins, N. A., Garber, J., Kane, M., and Kolodner, R. The human mutator gene homolog msh2 and its association with hereditary nonpolyposis colon cancer. Cell, 75: 1027–1038, 1993.
6. Nicolaides, N. C., Papadopoulos, N., Liu, B., Wei, Y. F., Carter, K. C., Ruben, S. M., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., Adams, M. D., Venter, J. C., Dunlop, M. C., Hamilton, S. R., Petersen, G. M., de la Chapelle, A., Vogelstein, B., and Kinzler, K. W. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature (Lond.), 371: 75–80, 1994.
7. Koi, M., Umar, A., Chauhan, D. P., Cherian, S. P., Carethers, J. M., Kunkel, T. A., and Boland, C. R. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces W-methyl-W-nitro-W-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLHl mutation. Cancer Res., 54: 4308–4312, 1994.
8. Parsons, R., Li, G. M., Longley, M. J., Fang, W., Papadopoulos, M., Jen, J., de la Chapelle, A., Kinzler, K. W., Vogelstein, B., and Modrich, P. Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell, 75: 1227–1236, 1993.
9. Umar, A., Boyer, J. C., Thomas, D. C., Nguyen, D. C., Risinger, J. I., Boyd, J., Ionov, Y., Perucho, M., and Kunkel, T. A. Defective mismatch repair in extracts of colorectal and endometrial cancer cells lines exhibiting microsatellite instability. J. Biol. Chem., 269: 14367–14370, 1994.
10. Karran, P., and Bignami, M. Self-destruction and tolerance in resistance of mammalian cells to alkylation damage. Nucleic Acids Res., 12: 2933–2940, 1992.
11. Green, M. H. L., Lowe, J. E., Petit-Frere, C., Karran, P., Hall, J., and Kataoka, H. Properties of N-methyl-jV-nitrosourea-resistant, Mex- derivatives of an SV40-immor-talized human fibroblast cell line. Carcinogenesis (Lond.), 10: 893–898, 1989.
12. Aquilina, G., Hess, P., Branch, P., MacGeoch, C., Casciano, I., Karran, P., and Bignami, M. A mismatch recognition defect in colon carcinoma confers DNA microsatellite instability and a mutator phenotype. Proc. Natl. Acad. Sci. USA, 91: 8905–8909, 1994.
13. Kat, A., Thilly, W. G., Fang, W.-H., Longley, M. J., Li, G.-M., and Modrich, P. An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc. Natl. Acad. Sci. USA, 90: 6424–6428, 1993.
14. Aquilina, G., Giammarioli, A. M., Zijno, A., DiMuccio, A., Dogliotti, E. and Bignami, M. Tolerance to O6-methylguanine and 6-thioguanine cytotoxic effects: a cross-resistant phenotype in N-methylnitrosourea-resistant Chinese hamster ovary cells. Cancer Res., 50: 4248–4253, 1990.
15. Aquilina, G., Zijno, A., Moscufo, N., Dogliotti, E., and Bignami, M. Tolerance to methylnitrosourea-induced DNA damage is associated with 6-thioguanine resistance in CHO cells. Carcinogenesis (Lond.), 10: 1219–1223, 1989.
16. Rappaport, H. P. The 6-thioguanine/5-methyl-2-pyrimidinone base pair. Nucleic Acids Res., 16: 7253–7267, 1988.
17. Brunk, C. F., Jones, K. C., and James, T. W. Assay for nanogram quantities of DNA in cellular homogenates. Anal. Biochem., 92: 497–500, 1979.
18. Miller, S. A., Dykes, D. D., and Polesky, H. F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res., 16: 1215, 1988.
19. Tidd, D. M., and Peterson, A. R. P. Distinction between inhibition of purine synthesis and delayed cytotoxic reaction of 6-MP. Cancer Res., 34: 733–737, 1974.
20. Maybaum, J., Morgans, C. W., and Hink, L. A. Comparison of in vivo and in vitro effects of continuous exposure of LI 210 cells to 6-thioguanine. Cancer Res., 47: 3083–3087, 1987.
21. vanDiggelen, O. P., Donahue, T. F., and Shin, S.-I. Basis for differential cellular sensitivity to 8-azaguanine and 6-thioguanine. J. Cell Physiol., 98: 59–72, 1979.
22. Thomas, D. C., Roberts, J. D., and Kunkel, T. A. Heteroduplex repair in extracts of human HeLa cells. J. Biol. Chem., 266: 3744–3751, 1991.
23. Wotring, L. L., and Roti Roti, J. L. Thioguanine-induced S and G2 blocks and their significance to the mechanism of cytotoxicity. Cancer Res., 40: 1458–1462, 1980.
24. Fishel, R., Ewel, A., and Lescoe, M. K. Purified human MSH2 protein binds to DNA containing mismatched nucleotides. Cancer Res., 54: 5539–5542, 1994.
25. Prolla, T. A., Pang, Q., Alani, E., Kolodner, R. D., and Liskay, R. M. MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast. Science (Washington DC), 265: 1091–1093, 1994.
26. Modrich, P. Mechanisms and biological effects of mismatch repair. Annu. Rev. Genet., 25: 229–253, 1991.