Blood pressure lowering by pioglitazone: Evidence for a direct vascular effect

Journal of Clinical Investigation

Volumn 96, Issue 1, 1995, Pages 354-360

  Buchanan, Thomas A ^a,d   Meehan, Woemer P ^a   Jeng, Young Y ^b   Yang, Dong ^b   Chan, Timothy M ^b   Nadler, Jerry L ^c   Scott, Steven ^c   Rude, Robert K ^a   Hsueh, Willa A ^a  

^a School of Medicine ^*  (United States)

^b LAC USC MEDICAL CENTER   (United States)

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^d Unit 1 ^*  (United States)

Author keywords

Calcium; Hypertension; Insulin sensitivity; Norepinephrine; Vascular reactivity

Indexed keywords

ARGIPRESSIN; CALCIUM; INSULIN; MAGNESIUM; NORADRENALIN; PIOGLITAZONE; POTASSIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTERY CONSTRICTION; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VESSEL REACTIVITY; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; EXTRACELLULAR CALCIUM; GLUCOSE CLAMP TECHNIQUE; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR SMOOTH MUSCLE;

ANIMAL; ANTIHYPERTENSIVE AGENTS; AORTA; BLOOD PRESSURE; IN VITRO; INSULIN; MAGNESIUM; MALE; MUSCLE, SMOOTH, VASCULAR; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THIAZOLES;

EID: 0029142479     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118041     Document Type: Article

References (40)

1. Modan, M., H. Halkins, S. Almog, A. Lusky, A. Eshkol, M. Shefi, A. Shitrit, and Z. Fuchs. 1985. Hyperinsulinemia: a link between hypertension obesity and glucose intolerance. J. Clin. Invest. 75:809-817.
2. Ferrannini, E., R. Buzzigoli, R. Bonadonna, M. A. Giorico, M. Oleggini, L. Graziadei, R. Pedrinelli, L. Brandi, and S. Bevilacqua. 1987. Insulin resistance in essential hypertension. N. Engl. J. Med. 317:350-357.
3. Shen, D. C., S. M. Sheih, M. T. Fuh, D. A. Wu, Y. DI. Chen, and G. M. Reaven. 1988. Resistance to insulin-stimulated glucose uptake in patients with hypertension. J. Clin. Endocrinol. Metab. 66:580-583.
4. Ginsberg, H., G. Kimmerling, G. M. Olefsky, and G. M. Reavan. 1975. Demonstration of insulin resistance in untreated adult-onset diabetic subjects with fasting hyperglycemia. J. Clin. Invest. 55:454-461.
5. Kolterman, O. G., R. S. Gray, J. Griffin, P. Burstein, J. Insel, J. A. Scarlett, and J. M. Olefsky. 1981. Receptor and post-receptor defects contribute to the insulin resistance in non-insulin-dependent diabetes mellitus. J. Clin. Invest. 68:957-969.
6. Ikeda, H. S., S. Taketomi, Y. Sugiyama, Y. Shimura, T. Sohda, K. Meguro, and T. Fujita. 1990. Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals. Arzneim Forsch. Drug Res. 40:156-162.
7. Hoffman. C., and J. R. Colca. 1992. New oral thiazolidinedione antidiabetic agents act as insulin sensitizers. Diabetes Care. 15:1075-1078.
8. Hoffman, C. A., K. Lorenz, and J. R. Colca. 1991. Glucose transport deficiency in diabetic animals is corrected by treatment with the oral antihyperglyceic agent pioglitazone. Endocrinology. 129:1915-1925.
9. Hoffman, C. A., C. W. Edwards III, R. M. Hillman, and J. R. Colca. 1992. Treatment of insulin-resistant mice with the oral antidiabetic agent pioglitazone: evaluation of liver GLUT2 and PEP carboxykinase expression. Endocrinology. 130:734-740.
10. Zhang H. Y., S. R. Reddy, and T. A. Kotchen. 1994. Antihypertensive effect of pioglitazone is not invariably associate with increased insulin sensitivity. Hypertension. 24:106-110.
11. Sugiyama Y., Y. Shimura, and H. Ikeda. 1990. Effects of pioglitazone on hepatic and peripheral insulin resistance in Wistar fatty rats. Arzneim. Forsch. Drug Res. 40:436-440.
12. Oakes N. D., C. J. Kennedy, A. B. Jenkins, D. R. Laybutt, D. J. Chisholm, and E. W. Kraegen. 1994. A new antidiabetic agent, BRL 49635. reduces lipid availability and improves insulin action and glucoregulation in rats. Diabetes. 43:1203-1210.
13. Kemnitz, J. W., D. F. Elson, E. B. Roecker, S. T. Baum, R. N. Bergman, and M. D. Meglasson. 1994. Pioglitazone increases insulin sensitivity, reduces blood glucose, insulin, and lipid levels, and lowers blood pressure in obese, insulin-resistant rhesus monkeys. Diabetes. 43:204-211.
14. Lee M.-K., P. D. G. Miles, M. Khoursheed, K.-M. Gao, A. R. Moosa, and J. M. Olefsky. 1994. Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat. Diabetes. 43:1435-1439.
15. Iwamoto, Y., T. Kuzuya, A. Matsuda, T. Awata, S. Kumakura, G. Inooka, and I. Shiraishi. 1991. Effect of new oral antidiabetic agent CS-045 on glucose tolerance and insulin secretion in patients with NIDDM. Diabetes Care. 14:1083-1086.
16. Suter. S. L., J. J. Nolan, P. Wallace, B. Gumbiner, and J. M. Olefsky. 1992. Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects. Diabetes Care. 15:193-203.
17. Nolan J. J., B. Ludvik, P. Beerdsen, M. Joyce, and J. Olefsky. 1994. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N. Engl. J. Med. 331:1188-1193.
18. Buchanan, T. A., G. F. Sipos, N. M. Madrilejo, C. Liu, and V. Campese. 1992. Hypertension without peripheral insulin resistance in spontaneously hypertensive rats. Am. J. Physiol. 262:E14-E19.
19. Herbert, V., K. Law, C. Gottlieb, and S. Bleicher. 1965. Coated charcoal immunoassay of insulin. J. Clin. Endocrinol. Metab. 25:1375-1384.
20. Roberts. D. C. K., W. E. West, T. G. Redgrave, and J. B. Smith. 1974. Plasma cholesterol concentration in normal and cholesterol-fed rabbits. Atherosclerosis. 19:369-380.
21. Balon, T., A. Jasmin, S. Scott, W. P. Meehan, R. Rude, and J. L. Nadler. 1994. Dietary magnesium prevents fructose-induced insulin insensitivity in rats. Hypertension. 23(Pt 2): 1036-1039.
22. Resnick, L. M., B. T. Altura, R. K. Gupta, J. H. Laragh, M. H. Alderman, and B. M. Altura. 1993. Intracellular and extracellular magnesium depletion in type 2 (non-insulin-dependent) diabetes mellitus. Diabelologia. 36:767-770.
23. Wu, H. Y., Y. Y. Jeng, C. J. Yue, K. Y. Chyu, W. A. Hsueh, and T. M. Chan. 1994. Endothelial-dependent vascular effects of insulin and insulin-like growth factor-1 in the perfused rat mesenteric artery and aortic ring. Diabetes. 43:1027-1032.
24. Capponi, A. M., P. D. Lew, and M. B. Vallotton. 1985. Cytosolic free calcium levels in monolayers of cultured rat aortic smooth muscle cells. J. Biol. Chem. 260:7836-7842.
25. Pershadsingh, H. A., J. Szollosi, S. Benson, W. C. Hyun, B. G. Feuerstein, and T. W. Kurtz. 1993. Effects of ciglitazone on blood pressure and intracellular calcium metabolism. Hypertension. 21:1020-1023.
26. Zhang F., J. R. Sowers, J. L. Ram, P. R. Standley, and J. D. Peuler. 1994. Effects of pioglitazone on calcium channels in vascular smooth muscle. Hypertension. 24:170-175.
27. Ng, L., J. E. Davies, and M. Ameen. 1992. Intracellular free magnesium levels in vascular smooth muscle and striated muscle cells of the spontaneously hypertensive rat. Metabolism. 41:772-777.
28. Resnik, L., R. Grupta, H. Gruenspan, M. Alderman, and J. Laragh. 1990. Hypertension and peripheral insulin resistance: mediating role of intracellular free magnesium. Am. J. Hypertens. 3:373-379.
29. Touyz, R. M., and E. L. Schifrrin. 1993. The effect of angiotensin II on platelet intracellular free magnesium and calcium ionic concentrations in essential hypertension. J. Hypertens. 11:551-558.
30. Nadler, J., T. Buchanan, R. Natarajan, I. Antonipillai, R. Bergman, and R. Rude. 1993. Magnesium deficiency produces insulin resistance and increased thromboxane synthesis. Hypertension. 21:1024-1029.
31. Rude, R., C. Manoogian, L. Ehrilich, P. DeRusso, E. Ryzen, and J. Nadler. 1989. Mechanisms of blood pressure reduction by magnesium in man. Magnesium. 8:266-273.
32. Nadler, J., and S. Scott. 1994. Evidence that pioglitazone increases intercellular free magnesium concentration in freshly isolated rat adipocytes. Biochem. Biophys. Res. Commun. 202:416-421.
33. Dubey, R. K., H. Y. Zhang, S. R. Reddy, M. A. Boegehold, and T. A. Kotchen. 1993. Pioglitazone attenuates hypertension and inhibits growth of renal arteriolar smooth muscle in rats. Am. J. Physiol. R726-R732.
34. Wolf, G., U. Haberstroh, and E. G. Neilson. 1992. Angiotensin II stimulatyes the proliferation and buiothesynthesis of type I collagen in cultured murine mesangial cells. Am. J. Pathol. 140:95-107.
35. Byyny R. L., M. LoVerde, S. LLoyd, W. Mitchell, and B. Draznin. 1992. Cytosolic calcium and insulin resistance in elderly patients with essential hypertension. Am. J. Hypertens. 5:459-464.
36. Ohno Y., S. Suzuki, H. Yamakawa, M. Nlamura, K. Otsuka, and T. Saruta. 1993. Impaired insulin sensitivity in young, lean normotensive offspring of essential hypertensives: possible role of disturbed calcium metabolism. J. Hypertens. 11:421-426.
37. Draznin B., D. Lewis, N. Houlder, N. Sherman, M. Adamo, W. T. Garvey, D. LeRoith, and K. Sussman. Mechanism of insulin resistance induced by sustained levels of cytosolic free calcium in rat adipocytes. Endocrinology. 125:241-249.
38. Resnick L. M. 1993. Ionic basis of hypertension, insulin resistance, vascular disease and related disorders. Am. J. Hypertens. 6:123S-134S.
39. Laakso, M., S. V. Edelman, G. Brechtel, and A. D. Baron. 1990. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man: a novel mechanism for insulin resistance. J. Clin. Invest. 85:1844-1852.
40. Buchanan, T. A., H. Thawani, W. Kades, J. G. Modrall, F. A. Weaver, C. Laurel, R. Poppiti, A. Xiang, and W. A. Hsueh. 1993. Angiotensin II increases glucose utilization during acute hyperinsulinemia via a hemodynamic mechanism. J. Clin. Invest. 92:720-726.