(-)-Roemerine, an aporphine alkaloid from annona senegalensis that reverses the multidrug-resistance phenotype with cultured cells

Journal of Natural Products

Volumn 58, Issue 4, 1995, Pages 598-604

  You, Min ^a   Mahinda Wickramaratne, D B ^a   Silva, Gloria L ^a   Chai, Heebyung ^a   Chagwedera, Tangai E ^b   Farnsworth, Norman R ^a   Cordell, Geoffrey A ^a   Kinghorn, A Douglas ^a   Pezzuto, John M ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF ZIMBABWE   (Zimbabwe)

Author keywords

[No Author keywords available]

Indexed keywords

8,8' BISDIHYDROSIRINGENIN; ANTINEOPLASTIC ALKALOID; APOREINE; ISOCORYDINE; SYRINGARESINOL; UNCLASSIFIED DRUG; VINBLASTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CYTOTOXICITY; DRUG CONFORMATION; DRUG ISOLATION; DRUG POTENTIATION; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; MEDICINAL PLANT; MEMBRANE VESICLE; MULTIDRUG RESISTANCE; PLANT LEAF; STEREOCHEMISTRY;

AFRICA; ALKALOIDS; ANIMAL; ANTINEOPLASTIC AGENTS, PHYTOGENIC; DRUG RESISTANCE, MULTIPLE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMAN; IN VITRO; KB CELLS; MITOCHONDRIA, LIVER; PHENOTYPE; PLANTS, MEDICINAL; RATS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

ANNONA SENEGALENSIS;

EID: 0029141419     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np50118a021     Document Type: Article

References (26)

1. J.I. Durodola, Planta Med., 28, 32 (1975).
2. J.I. Durodola, Planta Med., 28, 231 (1975).
3. E.K. Adesogan and J.I. Durodola, Phytochemistry, 15, 1311 (1976).
4. S.C. Chhabra, R.L.A. Mahunnah, and E.N. Mshiu, J. Ethnopharmacol., 21, 253 (1987).
5. R.B. Bhat, E.O. Etejere, and V.T. Oladipo, Econ. bot., 44, 382 (1990).
6. J.C.W. Comley, Trop. Med. Parasitol., 41, 1 (1990).
7. A.C. Igweh and A.O. Onabanjo, Ann. Trop. Med. Parasitol., 83, 527 (1989).
8. A. Mackie and A.L. Misra, J. Sci. Food Agric., 7, 203 (1956).
9. A. Mackie and N. Ghatge, J. Sci. Food Agric., 9, 88 (1959).
10. E. Ekundayo and B. Oguntimein, Planta Med., 52, 202 (1986).
11. D. Bamba, G. Balansard, C. Maillard, G. Dumenil, and A. Gayte-Sorbier, Plantes Méd. Phytothér., 18, 36 (1984).
12. I.T.U. Eshiet, A. Akisanya, and D.A.H. Taylor, Phytochemistry, 10, 3294 (1971).
13. H. Shibuya, Y. Takeda, R.-S. Zhang, A. Tanitame, Y.-L. Tsai, and I. Kitagawa, Chem. Pharm. Bull., 40, 2639 (1992).
14. F. Abe and T. Yamauchi, Chem. Pharm. Bull., 34, 4340 (1986).
15. J.M. Zamora, H.L. Pearce, and W.T. Beck, Mol. Pharmacol., 33, 454 (1988).
16. T. Nozaka, F. Watanabe, S.-I. Tadaki, M. Ishino, I. Morimoto, J.-I. Kunitomo, H. Ishii, and S. Natori, Mutat. Res., 240, 267 (1990).
17. L. Marion and V. Grassie, J. Am. Chem. Soc., 66, 1290 (1944).
18. H. Guinaudeau, M. Lebouef, and A. Cavé, Lloydia, 38, 275 (1975).
19. B. Ringdahl, R.P.K. Chan, J.C. Craig, M.P. Cava, and M. Shamma, J. Nat. Prod., 44, 80 (1981).
20. H. Guinaudeau, M. Lebouef, and A. Cavé, J. Nat. Prod., 42, 325 (1979).
21. M.M. Badawi, S.S. Handa, A.D. Kinghorn, G.A. Cordell, and N.R. Farnsworth, J. Pharm. Sci., 72, 1285 (1983).
22. F. Abe and T. Yamauchi, Phytochemistry, 27, 575 (1988).
23. C.-Y. Duh, C.H. Phoebe Jr., J.M. Pezzuto, A.D. Kinghorn, and N.R. Farnsworth, J. Nat. Prod., 49, 706 (1986).
24. K. Likhitwitayawuid, C.K. Angerhofer, G.A. Cordell, J.M. Pezzuto, and N. Ruangrungsi, J. Nat. Prod., 56, 30 (1993).
25. A. Somanabandhu, S. Nitayangkura, C. Mahidol, S. Ruchirawat, K. Likhitwitayawuid, H.-L. Shieh, H. Chai, J.M. Pezzuto, and G.A. Cordell, J. Nat. Prod., 56, 233 (1993).
26. M. You, X. Ma, R. Mukherjee, N.R. Farnsworth, G.A. Cordell, A.D. Kinghorn, and J.M. Pezzuto, J. Nat. Prod., 57, 1517 (1994).