Synthesis of (Dialkylamino)alkyl-Disubstituted Pyrimido[5,6,1-de] acri dines, a Novel Group of Anticancer Agents Active on a Multidrug Resistant Cell Line

Journal of Medicinal Chemistry

Volumn 38, Issue 17, 1995, Pages 3282-3286

  Antonini, Ippolito ^a   Cola, Donatella ^a   Polucci, Paolo ^a   Bontemps Gracz, Maria ^b   Borowski, Edward ^b   Martelli, Sante ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b GDANSK UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 (DIMETHYLAMINO)ETHYL] 6 [[2 (DIMETHYLAMINO)ETHYL]AMINO]PYRIMIDO[5,6,1 DE]ACRIDINE 1,3,7 TRIONE; 2 [2 (DIMETHYLAMINO)ETHYL] 6 [[2 [(2 HYDROXYETHYL)AMINO]ETHYL]AMINO]PYRIMIDO[5,6,1 DE]ACRIDINE 1,3,7 TRIONE; ACRIDINE DERIVATIVE; AMETANTRONE; ANTINEOPLASTIC AGENT; DOXORUBICIN; GLYCOPROTEIN P; INTERCALATING AGENT; MITONAFIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; COLON ADENOCARCINOMA; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA L 1210; LEUKEMIA P 388; MALE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN;

ACRIDINES; ANIMAL; ANTINEOPLASTIC AGENTS; DRUG RESISTANCE, MULTIPLE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMAN; LEUKEMIA L1210; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0029135131     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00017a013     Document Type: Article

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