IPT: A novel iodinated ligand for the CNS dopamine transporter

Synapse

Volumn 20, Issue 4, 1995, Pages 316-324

  Kung, Mei‐Ping ^a   Essman, William D ^a   Frederick, Dana ^a   Meegalla, Sanath ^a   Goodman, Mark ^b   Mu, Mu ^a   Lucki, Irwin ^a   Kung, Hank F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

Autoradiography; Homogenate binding; Radioiodinated ligand

Indexed keywords

3BETA (4 CHLOROPHENYL) N (3 IODOALLYL) 2BETA NORTROPANECARBOXYLIC ACID METHYL ESTER; 3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; COCAINE DERIVATIVE; FLUOXETINE; MAZINDOL; NISOXETINE; PAROXETINE; UNCLASSIFIED DRUG; VANOXERINE;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BEHAVIOR; BINDING SITE; CENTRAL NERVOUS SYSTEM; DOPAMINE UPTAKE; IODINATION; LIGAND BINDING; LOCOMOTION; MALE; NEUROPSYCHIATRY; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMAL; AUTORADIOGRAPHY; BEHAVIOR, ANIMAL; BRAIN; CARRIER PROTEINS; COCAINE; CORPUS STRIATUM; IODINE RADIOISOTOPES; LIGANDS; MALE; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TISSUE DISTRIBUTION; TROPANES;

EID: 0029134955     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.890200405     Document Type: Article

References (39)

1. N‐Modified analogues of cocaine: Synthesis and inhibition of binding to the cocaine receptor
2. 3H]GBR12935 in Alzheimer's disease
3. 125I]RTI 55: A potent ligand for dopamine transporters
4. 125I] RTI‐55 to dopamine and serotonin transporters in rat brain
5. 3H] cocaine in striatum and its relationship to the dopamine transporter
6. 123I] 3β (4‐Iodophenyl)trophan,2b‐carboxylic acid methyl ester (RTI‐55), a unique cocaine receptor ligand for imaging the dopamine and serotonin transporters in vivo
7. 50) of an enzymatic reaction
8. 3H]spiperone binding: Evidence for accumulation in corpus striatum by agonist‐mediated receptor internalization
9. Iodinated tomoxetine derivatives as selective ligands for serotonin and norepinephrine uptake sites
10. Compounds affecting the central nervous system. 4. 3β‐Phenyltropane‐2‐carboxylic esters and analogs
11. 125I] RTI‐55 to dopamine transporter; Pharmacology and regional distribution with autoradiography
12. The pharmacological and anatomical substrates of the amphetamine response in the rat
13. 3H]lysergic acid diethylamide binding in mouse cortex and hippocampus in vivo and in vitro revealed by radioautography and rapid filtration studies
14. Anatomical differentiation within the nucleus accumbens of the locomotor stimulatory actions of selective dopamine agonists and d‐amphetamine
15. Synthesis and characterization of radioiodinated N (l‐iodopropen 2′ yl)‐2β‐carbomethoxy‐3β‐(4‐chlorophenyl)tropanes: Potential dopamine reuptake site imaging agents
16. 3H]GBR‐12935 binding to the dopamine transporter is decreased in the caudate nucleus in Parkinson's disease
17. Severe depletion of cocaine recognition sites associated with the dopamine transporter in Parkinson's diseased striatum
18. Sodiumsensitive cocaine binding to rat striatal membrane: Possible relationship to dopamine uptake sites
19. Amphetamine, cocaine and fencafamine: Relationship between locomotor and stereotype response profiles and caudate and accumbens dopamine dynamics
20. Molecular pharmacology of cocaine: A dopamine hypothesis and its implications
21. 125I‐iodovinyltetrabenazine to CNS vesicular monoamine transport sites
22. 123I]β‐CIT: Pharmacological characterization of brain uptake in nonhuman primates
23. 125I]iodophenyl)tropane‐3β‐carbozxylate in vitro binding to dopamine and serotonin transporters under “physiological” conditions
24. 125I]RTI‐55 binding to cocaine‐sensitive dopaminergic and serotonerigic uptake sites in the human brain
25. Protein measurement with Folin phenol reagent
26. Effect of 1‐(m‐chlorophenyl)‐piperazine and l‐(m‐trifluoromethyl)‐piperazine on locomotor activity
27. 3H]2β‐carbomethoxy‐3β‐(4‐fluorophenyl)tropane
28. LIGAND: A versatile computerized approach for characterization of ligand binding system
29. 125I]RTI‐55 binding to dog caudate dopamine transporter
30. Effects of chemical stimulation of the mesolimbic dopamine system upon locomotor activity
31. Radiolabeling of dopamine uptake sites in mouse striatum: Comparison of binding sites for cocaine, mazindol and GBR 12935
32. Cocaine receptors on dopamine transporters are related to self‐administration of cocaine
33. 3H]carboxymethoxy‐3β‐(4‐fluoropheny)tropane to the serotonin transporter
34. 125I]RTI‐55 an in vivo label for the serotonin transporter
35. In vivo imaging of dopamine reuptake sites in the primate brain using single photon emission computed tomography (SPECT) and iodine‐123 labeled RTI‐55
36. 3H]cocaine binding associated with dopamine uptake sites in the rat striatum and human putamen decraese after dopaminergic denervation and in Parkinson's disease
37. Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette's Syndrome
38. 125I]iodophenyl)tropane serotonin and dopamine transporters: Different ionic requirements for substrate and 2 beta‐carbomethoxy‐3 beta‐(4‐[125I]iodophenyl) tropane binding