The C/EBP Family of Transcription Factors

Immunobiology

Volumn 193, Issue 2-4, 1995, Pages 171-185

  Wedel, Angela ^a   Lomsziegler Heitbrock H W ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; LEUCINE ZIPPER PROTEIN; TRANSCRIPTION FACTOR;

ADIPOCYTE; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; DIMERIZATION; DNA BINDING; DNA SEQUENCE; ENHANCER REGION; GENE EXPRESSION; GENETIC TRANSCRIPTION; LIVER CELL; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FAMILY; TRANSACTIVATION;

EID: 0029134126     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0171-2985(11)80541-3     Document Type: Article

References (100)

1. Isolation of a recombinant copy of the gene encoding C/EBP
2. Evidence of changes in protease sensitivity and subunit exchange rate on DNA binding by C/EBP
3. Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization
4. Transcription factors 1: bZIP proteins
5. Constitutive monocyte-restricted activity of NF-M, a nuclear factor that binds to a C/EBP motif
6. CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials
7. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA
8. Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast
9. Cognate DNA binding specificity retained after leucine zipper exchange between GCN4 and C/EBP
10. Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding
11. Evidence that the leucine zipper is a coiled coil
12. Nuclear translocation of viral jun but not of cellular jun is cell cycle dependent
13. The DNA-binding domain of two bZIP transcription factors, the Epstein-Barr virus switch gene product EB1 and jun, is a bipartite nuclear targeting sequence
14. Nuclear localization signal(s) required for nuclear targeting of the maize regulatory protein Opaque-2
15. The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins
16. Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy
17. X-ray scattering indicates that the leucine zipper is a coiled coil
18. Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP
19. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells
20. A family of C/EBPrelated proteins capable of forming covalently linked leucine zipper dimers in vitro
21. X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil
22. Dimerization specificity of the leucine zipper-containing bZIP motif on DNA binding: prediction and rational design
23. Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta
24. Molecular characterization of the GCN4-DNA complex
25. Structural motif of the GCN4 DNA binding domain characterized by affinity cleaving
26. Scissors-grip model for DNA recognition by a family of leucine zipper proteins
27. Identification of three residues in the basic regions of the bZIP proteins GCN4, C/EBP and TAF-1 that are involved in specific DNA binding
28. Phosphorylation of CCAAT-enhancer binding protein by protein kinase C attenuates site-selective DNA binding
29. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription
30. Sequence-specific DNA binding by a short peptide dimer
31. Design of DNA-binding peptides based on the leucine zipper motif
32. The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex
33. An «attenuator domain» is sandwiched by two distinct transactivation domains in the transcription factor C/EBP
34. Identification two polypeptide segments of CCAAT/enhancer-binding protein required for transcriptional activation of the serum albumin gene
35. Conserved motifs in Fos and Jun define a new class of activation domain
36. Novel mechanism of C/EBP beta (NF-M) transcriptional control: activation through derepression
37. Phosphorylation at threonine-235 by a ras-dependent mitogenactivated protein kinase cascade is essential for transcription factor NF-IL6
38. Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain
39. Multiple forms of C/EBP beta bind the EFII enhancer sequence in the Rous sarcoma virus long terminal repeat [published erratum appears in Mol
40. Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region
41. C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements
42. The pSO subunit of NF-kappa B associates with the NF-IL6 transcription factor
43. Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction
44. Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8
45. Identification of a C/EBP-Rel complex in avian lymphoid cells
46. Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperative between C/EBP and NF-κ B
47. A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct proteinprotein interaction
48. Tissue-specific expression, development regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein
49. Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene
50. LAP (NF-IL-6), a tissue-specific transcriptional activator, is an inhibitor of hepatoma cell proliferation
51. A nuclear factor for IL-6-expression (NF-IL6) is a member of a C/EBP family
52. A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6
53. 1-acid glycoproteine gene acute phase responsive element by multiple isoforms of C/EBP and glucocorticoid receptor
54. The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms
55. Differential acute-phase response of rat kininogen genes involves type I and II interleukin-6 response elements
56. Induction of GADD153, a CCAAT/enhancer-binding protein (C/EBP)related gene, during the acute phase response in rats
57. Expression of the gene encoding alpha 1-acid glycoprotein in rabbit liver under acute-phase conditions involves induction and activation of beta and delta CCAAT -enhancer-binding proteins
58. Serum amyloid A gene expression under acute-phase conditions involves participation of inducible C/EBP-beta and C/EBP-delta and their activation by phosphorylation
59. CCAAT-enhancer binding protein: a component of a differentiation switch
60. Reciprocal regulation of adipogenesis by Myc and C/EBP alpha
61. CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-Ll adipocyte differentiation program
62. Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes
63. A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells
64. Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6
65. C/EBP-related protein 2 confers lipopolysaccaride-inducible expression of interleukin 6 and monocyte chemoattractant protein 1 to a lymphoblastic cell line
66. The NF-M transcription factor is related to C/EBP beta and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells
67. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages
68. The C/EBP family of transcriptional activators is functionally important for Ig VH promoter activity in vivo and in vitro
69. Activation of the Ig germ-line gamma 1 promoter
70. Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1
71. LAP, a novel member of the C/EBP gene familiy, encodes a liver-enriched transcriptional activator protein
72. IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP
73. eDNA clones encoding leucine-Zipper proteins which interact with G-CSF gene promoter element 1-binding protein
74. Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family
75. a1/EBP: a leukine zipper protein that binds CCAAT/enhancer elements in the avian leukosis virus long terminal repeat enhancer
76. Slow border cells, a locus required for a development regulated cell migration during oogenesis, encodes Drosophila C/EBP
77. The transcription factor HNF1 acts with C/EBPa to synergistically activate the human albumin promoter through a novel domain
78. A different combination of transcription factors modulates the expression of the human transferrin promoter in liver and Sertoli cells
79. Determination of tissue specificity of the enhancer by combinatorial operation of tissue-enriched transcription factors
80. A novel cis-acting element controlling the rat CYP2DS gene and requiring cooperative between C/EBP beta and an Sp1 factor
81. Regulatory elements and DNA-binding proteins mediating transcription from the chicken very-low-density apolipoprotein II gene
82. The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription
83. The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxy kinase (GTP)
84. LAP (NF-IL6) transactivates the collagen alpha 1(1) gene from a 5" regulatory region
85. Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter
86. Participation of the transcription factor C/EBP delta in the acute-phase rgulation of the human gene for complement component C3
87. A 58-base-pair region of the human C3 gene confers synergistic inducibility by interleukin-1 and interleukin-6
88. A family of constitutive C/EBP-like DNA binding proteins attenuate the IL-1 alpha induced, NF kappa B mediated trans-activation of the angiotensinogen gene acute-phase response element
89. Functional characterization of promoter elements involved in regulation of human B beta-fibrinogen expression
90. Regenerative changes in C/EBP alpha and C/EBP beta expression modulate binding to the C/EBP site in the c-fos promoter
91. Differentiation-induced gene expression in 3T3-Ll preadipocytes
92. Mouse insulin-responsive glucose transporter gene: characterization of the gene and trans-activation by the CCAAT/enhancer binding protein
93. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins
94. Upstream NFIL-6-like site located within a DNase I hypersensitivity region mediates LPSinduced transcription of the murine interleukin-1 beta gene
95. C/EBP beta regulation of the tumor necrosis factor alpha gene
96. Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-l-responsive element in the IL-6 gene
97. C/EBP, NF-kappa B, and c-Ets family members and transcriptional regulation of the cell-specific and inducible macrophage inflammatory protein 1 alpha immediate-early gene
98. Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types
99. Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors
100. Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses