An overview of the toxicology of HFA-134a (1,1,1,2-tetrafluoroethane)

Human & Experimental Toxicology

Volumn 14, Issue 9, 1995, Pages 715-720

  Alexander, D J ^a   Libretto, S E ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

HFA 134a; inhalation; metered dose inhalers; propellent; toxicology overview

Indexed keywords

CHLOROFLUOROCARBON; NORFLURANE; PROPELLANT;

AEROSOL; ANIMAL EXPERIMENT; CARCINOGENICITY; CELL CULTURE; DOG; DRUG SAFETY; GUINEA PIG; INHALATIONAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; REVIEW; TOXICITY TESTING; TOXICOLOGY; VAPOR;

ADMINISTRATION, INHALATION; AEROSOL PROPELLANTS; ANESTHETICS; ANIMAL; DOGS; EYE; FEMALE; HYDROCARBONS, FLUORINATED; MALE; MICE; RATS; REPRODUCTION; SKIN;

EID: 0029132070     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/096032719501400903     Document Type: Article

References (8)

1. Kontny MJ et al. Issues surrounding MDI formulation development with non-CFC propellants. J Aerosol Med 1991; 4: 181-187.
2. Programme for Alternative Fluorocarbon Toxicity Testing. HFA-134a Toxicology Summary, PAFT, April 1993.
3. Graepel P., Alexander DJ CFC replacements: Safety testing, approval for use in metered dose inhalers. J Aerosol Med 1991; 4: 193-200.
4. Organisation for Economic Cooperation and Development (OECD) Guidelines for testing of chemicals. Guideline numbers: 401 - Acute inhalation toxicology, 12 May 1981; 412 -Repeated dose inhalation toxicity 28 day or 14 day study, 12 May 1981; 453 - Combined chronic toxicity/carcinogenicity studies, 12 May 1981.
5. Cannon WC, Blanton EF, McDonald KE The flow-past chamber: An improved nose-only exposure system for rodents. Amer Ind Hyg Assoc J 1983; 44: 923-928.
6. Alexander DJ et al. Microcomputer-based system for administering metered dose aerosol formulations to dogs. Inhalation Toxicol 1993; 5: 415-425.
7. Alexander DJ et al. One year study in dogs of the toxicity of HFA-134a by inhalation. Inhalation Toxicol (in press).
8. Alexander DJ et al. HFA-134a (1,1,1,2-tetrafluoroethane): Lack of oncogenicity in rodents after inhalation. Hum Exp Toxicol (in press).