Transgenic mice expressing high levels of soluble TNF‐R1 fusion protein are protected from lethal septic shock and cerebral malaria, and are highly sensitive to Listeria monocytogenes and Leishmania major infections

European Journal of Immunology

Volumn 25, Issue 8, 1995, Pages 2401-2407

  Garcia, Iréne ^a   Miyazaki, Yoshitaka ^a   Araki, Kimi ^a   Araki, Masatake ^a   Lucas, Ralf ^a   Grau, Georges E ^a   Milon, Geneviéve ^b   Belkaid, Yasmine ^b   Montixi, Christine ^b   Lesslauer, Werner ^c   Vassalli, Pierre ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b INSTITUT PASTEUR   (France)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Leishmania major; Listeria monocytogenes; Septic shock; Transgenic mice; Tumor necrosis factor receptor 1 fusion protein

Indexed keywords

GALACTOSAMINE; HYBRID PROTEIN; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MALARIA; BREEDING; CELL PROTECTION; CONTROLLED STUDY; FEMALE; LEISHMANIA MAJOR; LETHALITY; LISTERIA MONOCYTOGENES; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; SENSITIZATION; SEPTIC SHOCK; TRANSGENE;

ANIMAL; ANTIGENS, CD; BASE SEQUENCE; CHIMERIC PROTEINS; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LISTERIA INFECTIONS; MALARIA, CEREBRAL; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; RECEPTORS, TUMOR NECROSIS FACTOR; SHOCK, SEPTIC; SUPPORT, NON-U.S. GOV'T; TUMOR NECROSIS FACTOR;

EID: 0029131488     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.1830250841     Document Type: Article

References (30)

1. Protective effect of 55- but not 75-kD soluble tumor necrosis factor receptor-immunoglobulin G fusion proteins in an animal model of gram- negative sepsis
2. Analysis of the Cellular Parameters of the Immune Responses contributing to Resistance and Susceptibility of Mice to Infection with the Intracellular Parasite, Leishmania major
3. Immunobiology of experimental Leishmaniasis