The somatic mutation theory of ageing

Mutation Research DNAging

Volumn 338, Issue 1-6, 1995, Pages 19-23

  Morley, Alexander A ^a  

^a FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

Aging; Dietary restriction; Free radicals; Somatic mutation

Indexed keywords

FREE RADICAL;

AGING; DNA DAMAGE; ETIOLOGY; LIFESPAN; PRIORITY JOURNAL; SHORT SURVEY; SOMATIC MUTATION;

AGING; ANIMAL; CELL DIVISION; CELL SURVIVAL; CHROMOSOMES; DIET; DNA, MITOCHONDRIAL; HUMAN; LONGEVITY; MUTATION;

EID: 0029131290     PISSN: 09218734     EISSN: None     Source Type: Journal    
DOI: 10.1016/0921-8734(95)00007-S     Document Type: Article

References (48)

1. Mutagenicily monitoring in humans by autoradiographic assay for mutant T lymphocytes
2. Effect of neotnatal exposure to 5-hromo-2′-deoxyuridine on life span, estrus function and tumor development in rats: an argument in favor of the mutation theory of aging?
3. Deleterious mitochondrial DNA mutations accumulate in aging human tissues
4. Modifications of DNA by reducing sugars: a possible mechanism for nucleic acid aging and age-related dysfunction in gene expression
5. Protection of DNA damage by dietary restriction
6. HPRT somatic mutation data
7. Detection of specific mitochondrial DNA deletion in tissues of older humans
8. Effect of dietary restriction on in vivo somatic mutation in mice
9. Oxidative damage to DNA during aging: 8-hydroxy-2′deoxyguanosine in rat organ DNA and urine
10. Genetic disease in the offspring of older fathers
11. In vivo human somatic mutation: frequency and spectrum with age
12. In vivo human somatic mutation: frequency and spectrum with age
13. Aging: a theory based on free radical and radiation chemistry
14. Age-dependent increase in deleted mitochondrial DNA in the human heart: possible contributory factor to presbycardia
15. Nuclear but not mitochondrial genome involvement in human agerelated mitochondrial dysfunction, Functional integrity of mitochondrial DNA from aged subjects
16. Age-associated damage in mitochondrial DNA in human hearts
17. The effect of the age of the father at conception on the mutations to hemophilia
18. Oxygen-dependent perturbation of life span and aging rate in the nematode
19. In vivo somatic mutations in the glycophorin A locus of human erythroid cells
20. Increased life-span of age-l mutants in Caenorhabditis elegans and lower Gompertz rate of aging
21. Development of a flow-cytometric HLA-A locus mutation assay for human peripheral blood lymphoctyes
22. Aging and resistance to oxidative damage in Caenorhabditis elegans
23. Comparative analysis of DNA mutations in lacI transgenic mice with age
24. BCL2 translation frequency rises with age in humans
25. Long-term effects of a single whole-body exposure of mice to ionizing radiations
26. Mitochondrial gene mutation: the ageing process and degenerative diseases
27. The HLA mutation assay: improved technique and normal results
28. Is ageing the result of dominant or co-dominant mutations?
29. Human aging is associated with various point mutations in tRNA genes of mitochondrial DNA
30. Ageing of clones of mammalian cells
31. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
32. Use of T cell cloning to detect in vivo mutations induced by cyclophosphamide
33. Age-dependent increases of DNA adducts (1-compunds) in human and rat brain DNA
34. DNA repair and longevity assurance in Paramecium tetraurelia
35. Decreased fidelity of DNA polymerases and decreased DNA excision repair in aging mice: effects of caloric restriction
36. On the nature of aging process
37. Detection of somatic mutants in man HPRT mutations in lymphocytes and hemoglobin mutations in erythrocytes
38. Mutation frequency in human lymphocytes increases with age
39. Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing
40. Age-related development of a heterozygous phenotype in solitary neurons of the homozygous Brattleboro rat
41. Measurement of spontaneous and X-irradiation-induced 6-thioguanineesistant human blood lymphocytes using a T-cell cloning technique
42. The duration of life
43. Pleiotrophy natural selection and the evolution of senescence
44. Protein oxidation associated with aging is reduced by dietary restriction of protein or calories
45. Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans