Synthesis and Evaluation of 5-Amino-5,6,7,8-tetrahydroquinolinones as Potential Agents for the Treatment of Alzheimer’s Disease

Journal of Medicinal Chemistry

Volumn 38, Issue 18, 1995, Pages 3645-3651

  Fink, David M ^a   Bores, Gina M ^a   Effland, Richard C ^a   Huger, Francis P ^a   Kurys, Barbara E ^a   Rush, Douglas K ^a   Selk, David E ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

5,5' DITHIOBIS(2 NITROBENZOIC ACID); 5,6,7,8 TETRAHYDRO 5 QUINOLINAMINE DERIVATIVE; ACETYLCHOLINE; ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; GALANTAMINE; HUPERZINE A; PHYSOSTIGMINE; QUINOLINE DERIVATIVE; SCOPOLAMINE BROMIDE; TACRINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; DEMENTIA; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MALE; MEMORY; MOUSE; NONHUMAN; PASSIVE AVOIDANCE; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMINOQUINOLINES; ANIMAL; CHOLINESTERASE INHIBITORS; DEMENTIA; DRUG EVALUATION; MALE; MICE; RATS; SCOPOLAMINE; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029131257     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00018a025     Document Type: Article

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