Vascular Endothelial Growth Factor and Platelet-derived Endothelial Cell Growth Factor Are Frequently Coexpressed in Highly Vascularized Human Breast Cancer

Clinical Cancer Research

Volumn 1, Issue 9, 1995, Pages 961-964

  Toi, Masakazu ^a   Inada, Kazuo ^a   Hoshina, Seigo ^a   Tominaga, Takeshi ^a   Suzuki, Hideo ^b   Kondo, Shinichi ^b  

^a TOKYO METROPOLITAN KOMAGOME HOSPITAL   (Japan)

^b Base Technology Center   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; BREAST CANCER; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MICROVASCULATURE; PRIORITY JOURNAL;

BREAST NEOPLASMS; CARCINOMA, INFILTRATING DUCT; ENDOTHELIAL GROWTH FACTORS; FEMALE; HUMAN; LYMPHOKINES; NEOPLASM PROTEINS; THYMIDINE PHOSPHORYLASE;

EID: 0029128360     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Folkman, J. What is the evidence that tumors are angiogenesis dependent? J. Natl. Cancer Inst., 82: 4–6, 1990.
2. Bicknell, R., and Harris, A. L. Novel growth regulatory factors and tumor angiogenesis. Eur. J. Cancer, 27: 781–784, 1991.
3. Ferrara, N., and Henzel, W. J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun., 161: 851–858, 1989.
4. Senger, D. R., Galli, S. J., Dvorak, A. M., Perruzzi, C. A., Harvey, V. S., and Dvorak, H. F. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science (Washington DC), 279; 983–985, 1983.
5. Ishikawa, F., Miyazono, K., Heilman, U., Drexler, H., Wemstedt, C., Hagiwara, K., Usuki, K., Takaku, F., Risau, W., and Heldin, C. H. Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature (Lond.), 338: 557–562, 1989.
6. Shibuya, M., Yamaguchi, A., and Yamane, T. Nucleotide sequence and expression of a novel human receptor type tyrosine kinase gene (fit) closely related to the fins family. Oncogene, 5: 519, 1990.
7. De Vries, C., Escobedo, J. A., and Ueno, H. The fms-like kinase, a receptor for vascular endothelial growth factor. Science (Washington DC), 255: 989–991, 1992.
8. Terman, B. I., Dougher-Vermazen, M., and Carrion, M. E. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem. Biophy. Res. Commun., 187: 1579–1586, 1992.
9. Millauer, B., Wizigmann-Vos, S., and Schnurch, H. High affinity VEGF binding and developmental expression suggest flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell, 72: 835–846, 1993.
10. Furukawa, T., Yoshimura, A., Sumizawa, T., Haraguchi, M., Akiyama, S., Fukui, K., Ishizawa, M., and Yamada, Y. Angiogenic factor. Nature (Lond.), 356: 668, 1992.
11. Toi, M., Hoshina, S., Takayanagi, T., and Tominaga, T. Association of vascular endothelial growth factor expression with tumor angiogenesis and early response in primary breast cancer. Jpn. J. Cancer Res., 85: 1045–1049, 1994.
12. Toi, M., Inada, K., Suzuki, H., and Tominaga, T. Tumor angiogenesis in breast cancer: its importance as a prognostic indicator and the association with vascular endothelial growth factor expression. Breast Cancer Res. Treat., in press, 1995.
13. Toi, M., Hoshina, S., Taniguchi, T., Yamamoto, Y., Ishitsuka, H., and Tominaga, T. Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer. Int. J. Cancer, in press, 1995.
14. Toi, M., Kashitani, J., and Tominaga, T. Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma. Int. J. Cancer, 55: 371–374, 1993.
15. Ferrara, N., Houck, K. A., Jakeman, L. B., Winer, J., and Leung, D. W. The vascular endothelial growth factor family of polypeptides. J. Cell Biochem., 47: 211–218, 1991.
16. Usuki, K., Saras, J., Waltenberger, J., Miyazono, K., Pierce, G., Thomason, A., and Heldin, C. H. Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity. Biochem. Biophys. Res. Commun., 184: 1311–1316, 1992.
17. Moghaddam, A., and Bicknell, R. Expression of platelet-derived endothelial cell growth factor in Escherichia coli and confirmation of its thymidine phosphorylase activity. Biochemistry, 31: 12141–12146, 1992.
18. Haraguchi, M., Miyadera, K., Uemura, K., Sumizawa, T., Furukawa, T., Yamada, K., Akiyama, S., and Yamada, Y. Angiogenic activity of enzymes. Nature (Lond.), 368: 198, 1994.
19. Eda, H., Fujimoto, K., Watanabe, S., Ura, M., Hino, A., Tanaka, Y., Wada, K., and Ishitsuka, H. Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5'-deoxy- 5-fluorouridine. Cancer Chemother. Pharmacol., 32: 333–338, 1993.
20. Kieser, A., Weich, H. A., and Brandner, G. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene, 9: 963–969, 1994.
21. Weidner, N., Folkman, J., Pozza, F., Bevilacqua, P., Allred, E. N., Moore, D. H., Meli, S., and Gasparini, G. Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J. Natl. Cancer Inst., 84: 1875–1887, 1992.
22. Horak, E. R., Leek, R., Klenk, N., Lejeune, S., Smith, K., Stuart, N., Greenall, M., Stepniewska, K., and Harris, A. L. Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer. Lancet, 340: 1120–1124, 1992.
23. Gasparini, G., Weidner, N., Bevilacqua, P., Maluta, S., Palma, P. D., Caffo, O., Barbareschi, M., Boracchi, P., Marubini, E., and Pozza, F. Tumor microvessel density, p53 expression, tumor size, and peritu- moral lymphatic invasion are relevant prognostic markers in nodenegative breast carcinoma. J. Clin. Oncol., 12: 446–454, 1994.
24. Wakui, S., Furusato, M., and Itoh, T. Tumor angiogenesis in prostatic carcinoma with and without bone marrow metastasis: a morpho- metric study. J. Pathol., 168: 257–262, 1992.
25. Gasparini, G., Weidner, N., and Maluta, S. Intratumoral microvessel density and p53 protein: correlation with metastasis in head and neck squamous cell carcinoma. Int. J. Cancer, 55: 739–744, 1993.
26. Craff, P. S., and Harris, A. L. Prognostic significance of tumor angiogenesis. Ann. Oncol., 5: 305–311, 1994.
27. Dameron, K. M., Volpert, O. V., Tainsky, M. A., and Bouck, N. Control of angiogenesis in fibroblasts by p53 regulation of throm- bospondin-1. Science (Washington DC), 265: 1582–1584, 1994.
28. O’Reilly, M. S., Holmgren, L., Shing, Y., Chen, C., Rosenthal, R. A., Moses, M., Lane, W. S., Cao, Y., Sage, E. H., and Folkman, J. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell, 79: 315–328, 1994.
29. Kim, K. J., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., and Ferrara, N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature (Lond.), 362: 841–844, 1993.
30. Kondo, S., Asano, M., and Suzuki, H. Significance of vascular endothelial growth factor/vascular permeability factor for solid tumor growth, and its inhibition by the antibody. Biochem. Biophys. Res. Commun., 194: 1234–1241, 1993.
31. Yayoi, K., Takatsuka, Y., Maeura, Y., Kotsuma, Y., Kobayashi, T., Aikawa, T., Hirai, T., Kaji, M., Kitada, M., and Tatsuta, M. Comparison of response to 5'-deoxy-5-fluoropyrimidine therapy alone and in combination with tamoxifen or medroxyprogesterone acetate in advanced and recurrent breast cancer. Int. J. Oncol., 5: 27–32, 1994.