Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound

Journal of Biological Chemistry

Volumn 270, Issue 38, 1995, Pages 22467-22472

  Williamson, Richard A ^a   Yea, Christopher M ^a   Robson, Peter A ^a   Curnock, Adam P ^a   Gadher, Suresh ^a   Hambleton, Anne B ^a   Woodward, Katherine ^a   Bruneau, Jean Michel ^b   Hambleton, Philip ^a   Moss, David ^a   Thomson, T Andrew ^a   Spinella Jaegle, Sylvian ^b   Morand, Philippe ^a   Courtini, Olivier ^c   Sautés, Catherine ^d   Westwood, Robert ^b   Hercend, Thierry ^b   Kuo, Elizabeth A ^a   Ruuth, Erik ^b  

^a Immunology Domain   (United Kingdom)

^b SANOFI   (France)

^c Roussel Uclaf ^*  (France)

^d INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROOROTATE DEHYDROGENASE; IMMUNOMODULATING AGENT; LEFLUNOMIDE; TERIFLUNOMIDE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; DRUG PROTEIN BINDING; ENZYME INHIBITION; GRAFT VERSUS HOST REACTION; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN ISOLATION; PROTEIN SYNTHESIS; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANILINE COMPOUNDS; ANIMAL; BINDING SITES; CELL DIVISION; GROWTH INHIBITORS; HYDROXYBUTYRATES; MICE; MICROSOMES; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OXIDOREDUCTASES; SPLEEN; URIDINE;

ANIMALIA; MURINAE;

EID: 0029127555     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.270.38.22467     Document Type: Article

References (24)