Epolactaene, a Novel Neuritogenic Compound in Human Neuroblastoma Cells, Produced by a Marine Fungus

The Journal of Antibiotics

Volumn 48, Issue 7, 1995, Pages 733-735

  Kakeya, Hideaki ^a   Takahashi, Isamu ^b   Okada, Gen ^a   Isono, Kiyoshi ^b   Osada, Hiroyuki ^a  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^b KAKEN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPOLACTAENE; NEUROTROPIC AGENT; UNCLASSIFIED DRUG;

CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG MANUFACTURE; DRUG STRUCTURE; DRUG SYNTHESIS; FUNGUS; HUMAN; HUMAN CELL; LETTER; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTIBIOTICS, ANTINEOPLASTIC; EPOXY COMPOUNDS; FUNGI; HUMAN; MOLECULAR STRUCTURE; NEUROBLASTOMA; PENICILLIUM; POLYENES; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0029127496     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.48.733     Document Type: Article

References (7)

1. Vantini, G. & S. D. Skaper: Neurotrophic factors; from physiology to pharmacology?. Pharmacological Research 26: 1–15, 1992
2. Barde, Y.-A.: Trophic factors and neuronal survival. Neuron 2: 1525–1534, 1989
3. Ross, R. A. & J. L. Biedler: Presence and regulation of tyrosinase activity in human neuroblastoma cell variants in vitro. Cancer Res. 45: 1628—1632, 1985
4. Gelderblom, W. C. A.; W. F. O. Marasas, P. S. Steyn, P. G. Thiel, K. J. Van Der Merwe, P. H. Van Rooyen, R. Vleggaar & P. L. Wessels: Structure elucidation of fusarin C, a mutagen produced by Fusarium moniliforme. J. Chem. Soc., Chem. Commun. 1984: 122—124, 1984
5. 13C shifts. J. Agric. Food Chem. 33: 652 — 654, 1985
6. ŌMura, S.; T. Fujimoto, K. Otoguro, K. Matsuzaki, R. Moriguchi, H. Tanaka & Y. Sasaki: Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells. J. Antibiotics 44: 113 — 116, 1991
7. Toki, S.; K. Ando, M. Yoshida & Y. Matsuda: PS-990, a novel neuritogenic compound from Acremonium sp. J. Antibiotics 47: 1175–1181, 1994