The endoeytie activity of dendritic cells

Journal of Experimental Medicine

Volumn 182, Issue 2, 1995, Pages 283-288

  Steinman, Ralph M ^a   Swanson, Joel ^b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ADSORPTION; ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; B LYMPHOCYTE; DENDRITIC CELL; ENDOCYTOSIS; ENDOSOME; LYSOSOME; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; NOTE; PINOCYTOSIS; PRIORITY JOURNAL;

ANIMAL; ANTIGEN-PRESENTING CELLS; DENDRITIC CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMAN; PINOCYTOSIS;

EID: 0029127063     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.182.2.283     Document Type: Article

References (62)

1. Sallusto, F., M. Celia, C. Danielli, and A. Lanzavecchia. 1995. Dendritic cells use macropinocytosis and the mannose receptor to concentrate antigen in the MHC class II compartment. Downregulation by cytokines and bacterial products. J. Exp Med. 182: 389-400.
2. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor a. J. Exp Med. 179: 1109-1118.
3. Mishell, R.I., and R.W. Dutton. 1967. Immunization of dissociated spleen cell cultures from normal mice. J. Exp Med. 126: 423-442.
4. Steinman, R.M., and Z.A. Cohn. 1973. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J. Exp Med. 137: 1142-1162.
5. Steinman, R.M., and Z.A. Cohn. 1974. Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro. J. Exp Med. 139: 380-397.
6. Steinman, R.M., J.C. Adams, and Z.A. Cohn. 1975. Identification of a novel cell type in peripheral lymphoid organs of mice. IV. Identification and distribution in mouse spleen. J. Exp Med. 141: 804-820.
7. Steinman, R.M., G. Kaplan, M.D. Witmer, and Z.A. Cohn. 1979. Identification of a novel cell type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro. J. Exp Med. 149: 1-16.
8. Schuler, G., and R.M. Steinman. 1985. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J. Exp Med. 161: 526-546.
9. Kleijmeer, M.J., V.M.J. Oorschot, and H.J. Geuze. 1994. Human resident Langerhans cells display a lysosomal compartment enriched in MHC class II. J. Invest. Dermatol. 103: 516-523.
10. Nijman, H.W., M.J. Kleijmeer, M.A. Ossevoort, V.M.J. Oorschot, M.P.M. Vierboom, M. van de Keur, P. Kenemans, W.M. Kast, H.J. Geuze, and C.J.M. Melief. 1995. Antigen capture and MHC class II compartments of freshly isolated and cultured human blood dendritic cells. J. Exp Med. 182: 163-174.
11. Klinkert, W.E.F., J.H. Labadie, and W.E. Bowers. 1982. Accessory and stimulating properties of dendritic cells and macrophages isolated from various rat tissues. J. Exp Med. 156: 1-19.
12. Kelly, R.H., B.M. Balfour, J.A. Armstrong, and S. Griffiths. 1978. Functional anatomy of lymph nodes. II. Peripheral lymph-borne mononuclear cells. Anat. Rec 190: 5-21.
13. Pugh, C.W., G.G. MacPherson, and H.W. Steer. 1983. Characterization of nonlymphoid cells derived from rat peripherallymph. J. Exp Med. 157: 1758-1779.
14. Wolff, K., and E. Schreiner. 1970. Uptake, intracellular transport, and degradation of exogenous protein by Langerhans cells. J. Invest. Dermatol. 54: 37-52.
15. Van Voorhis, W.C., L.S. Hair, R.M. Steinman, and G. Kaplan. 1982. Human dendritic cells. Enrichment and characterization from peripheral blood. J. Exp. Med. 155: 1172-1187.
16. Hart, D.N., and J.L. McKenzie. 1988. Isolation and characterization of human tonsil dendritic cells. J. Exp Med. 168: 157-170.
17. Eikelenboom, P. 1978. Characterization of non-lymphoid cells in the white pulp of the mouse spleen: an in vivo and in vitro study. Cell. Tissue Res. 195: 445-460.
18. Dijkstra, C.D. 1982. Characterization of nonlymphoid cells in rat spleen, with special reference to strongly Ia-positive branched cells in T-cell areas. J. Reticuloendothel. Soc 32: 167-178.
19. Steinman, R.M. 1991. The dendritic cell system and its role in immunogenicity. Ann. Rev. Immunol. 9: 271-296.
20. Kaye, P.M., B.M. Chain, and M. Feldmann. 1985. Nonphagocytic dendritic cells are effective accessory cells for antimycobacterial responses in vitro. J. Immunol. 134: 1930-1934.
21. Kapsenberg, M.L., M.B.M. Teunissen, F.E.M. Stiekema, and H.G. Keizer. 1986. Antigen-presenting cell function of dendritic cells and macrophages in proliferative T cell responses to soluble and particulate antigens. Eur. J. Immunol. 16: 345-350.
22. Crowley, M., K. Inaba, and R.M. Steinman. 1990. Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins. J. Exp. Med. 172: 383-386.
23. Pancholi, P., A. Mirza, V. Schauf, R.M. Steinman, and N. Bhardwaj. 1993. Presentation of mycobacterial antigens by human dendritic cells: lack of transfer from infected macrophages. Infect. Immun. 61: 5326-5332.
24. Steinman, R.M., and Z.A. Cohn. 1972. The interaction of soluble horseradish peroxidase with mouse peritoneal macrophages in vitro. J. Cell Biol. 55: 186-204.
25. Steinman, R.M., and Z.A. Cohn. 1972. The interaction of particulate horseradish peroxidase (HRP)-anti HRP immune complexes with mouse peritoneal macrophages in vitro. J. Cell Biol. 55: 616-634.
26. Harding, C.V., and E.R. Unanue. 1990. Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation. Nature (Land.). 346: 574-576.
27. Demotz, S., H.M. Grey, and A. Sette. 1990. The minimal number of class II MHC-antigen complexes needed for T cell activation. Science (Wash. DC). 249: 1028-1030.
28. Bhardwaj, N., J.W. Young, A.J. Nisanian, J. Baggers, and R.M. Steinman. 1993. Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responses. J. Exp Med. 178: 633-642.
29. Nussenzweig, M.C., R.M. Steinman, J.C. Unkeless, M.D. Witmer, B. Gutchinov, and Z.A. Cohn. 1981. Studies of the cell surface of mouse dendritic cells and other leukocytes. J. Exp Med. 154: 168-187.
30. Hunt, D.F., H. Michel, T.A. Dickinson, J. Shabanowitz, A.L. Cox, K. Sakaguchi, E. Appella, H.M. Grey, and A. Sette. 1992. Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad. Science (Wash. DC). 256: 1817-1820.
31. Inaba, K., J.P. Metlay, M.T. Crowley, and R.M. Steinman. 1990. Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ. J. Exp Med. 172: 631-640.
32. Tony, H.P., and D.C. Parker. 1985. Major histocompatibility complex-restricted, polyclonal B cell responses resulting from helper T cell recognition of antiimmunoglobulin presented by small B lymphocytes. J. Exp Med. 161: 223-241.
33. Rock, K.L., B. Benacerraf, and A.K. Abbas. 1984. Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. J. Exp. Med. 4: 1102-1113.
34. Lanzavecchia, A. 1985. Antigen-specific interaction between T and B cells. Nature (Lond.). 314: 537-539.
35. Zaghouani, H., R.M. Steinman, R. Nonacs, H. Shah, W. Gerhard, and C. Bona. 1993. Efficient presentation of a viral T helper epitope expressed in the CDR3 region of a self immunoglobulin molecule. Science (Wash. DC). 259: 224-227.
36. Schuler, G., N. Romani, G. Stingl, and K. Wolff. 1983. Coated Langerhans cell granules in histiocytosis X cells. Ultrastruct. Pathol. 5: 77-82.
37. Takigawa, M., K. Iwatsuki, M. Yamada, H. Okamoto, and S. Imamura. 1985. The Langerhans cell granule is an adsorptive endocytic organelle. J. Invest. Dermatol. 85: 12-15.
38. Ray, A., D. Schmitt, C. Dezutter-Dambuyant, M.-C. Fargier, and J. Thivolet. 1989. Reappearance of CDla antigenic sites after endocytosis on human Langerhans cells evidenced by immunogold relabeling. J. Invest. Dermatol. 92: 217-224.
39. Jiang, W., W.J. Swiggard, C. Heufler, M. Peng, A. Mirza, R.M. Steinman, and M.C. Nussenzweig. 1995. DEC-205, a receptor expressed by dendritic cells and thymic epithelial cells, has ten C-type lectin domains and is involved in antigen presentation. Nature (Lond.). 305: 151-155.
40. Steinman, R.M., I.S. Mellman, W.A. Muller, and Z.A. Cohn. 1983. Endocytosis and the recycling of plasma membrane. J. Cell Biol. 96: 1-27.
41. Levine, T.P., and B.M. Chain. 1992. Endocytosis by antigen presenting cells: dendritic cells are as endocytically active as other antigen presenting cells. Proc Natl. Acad. Sci. USA. 89: 8342-8346.
42. Romani, N., S. Koide, M. Crowley, M. Witmer-Pack, A.M. Livingstone, C.G. Fathman, K. Inaba, and R.M. Steinman. 1989. Presentation of exogenous protein antigens by dendritic cells to T cell clones: intact protein is presented best by immature, epidermal Langerhans cells. J. Exp Med. 169: 1169-1178.
43. Streilein, J.W., and S.F. Grammer. 1989. In vitro evidence that Langerhans cells can adopt two functionally distinct forms capable of antigen presentation to T lymphocytes. J. Immunol. 143: 3925-3933.
44. Puré, E., K. Inaba, M.T. Crowley, L. Tardelli, M.D. Witmer-Pack, G. Ruberti, G. Fathman, and R.M. Steinman. 1990. Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain. J. Exp Med. 172: 1459-1469.
45. Kampgen, E., N. Koch, F. Koch, P. Stoger, C. Heufler, G. Schuler, and N. Romani. 1991. Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture. Proc Natl. Acad. Sci. USA. 88: 3014-3018.
46. Witmer-Pack, M.D., J. Valinsky, W. Olivier, and R.M. Steinman. 1988. Quantitation of surface antigens on cultured murine epidermal Langerhans cells: rapid and selective increase in the level of surface MHC products. J. Invest. Dermatol. 90: 387-394.
47. Stossel, H., F. Koch, E. Kampgen, P. Stoger, A. Lenz, C. Heufler, N. Romani, and G. Schuler. 1990. Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells. J. Exp Med. 172: 1471-1482.
48. Inaba, K., M. Inaba, M. Naito, and R.M. Steinman. 1993. Dendritic cell progenitors phagocytose particulates, including Bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J. Exp Med. 178: 479-488.
49. Reise Sousa, C., P.D. Stahl, and J.M. Austyn. 1993. Phagocytosis of antigens by Langerhans cells in vitro. J. Exp Med. 178: 509-519.
50. Brunk, U., J. Schellens, and B. Westermark. 1976. The influence of epidermal growth factor on ruffling activity, pinocytosis and proliferation of cultivated human glial cells. Exp. Cell Res. 103: 295-302.
51. Racoosin, E.L., and J.A. Swanson. 1989. Macrophage colony stimulating factor (rM-CSF) stimulates pinocytosis in bone marrow-derived macrophages. J. Exp Med. 170: 1635-1648.
52. Haigler, H.T., J.A. McKanna, and S. Cohen. 1979. Rapid stimulation of pinocytosis in human carcinoma cells A-431 by epidermal growth factor. J. Cell Biol. 83: 82-90.
53. Wiley, H.S., and D.D. Cunningham. 1982. Epidermal growth factor stimulates fluid phase endocytosis in human fibroblasts through a signal generated at the cell surface. J. Cell. Biochem. 19: 383-394.
54. Bar-Sagi, D., and J.R. Feramisco. 1986. Induction of membrane fuffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins. Science (Wash. DC). 233: 1061-1066.
55. Francis, C.L., T.A. Ryan, RD. Jones, S.J. Smith, and S. Falkow. 1993. Ruffles induced by salmonella and other stimuli direct macropinocytosis of bacteria. Nature (Lond.). 364: 639-642.
56. Alpuche-Aranda, C.M., E.L. Racoosin, J.A. Swanson, and S.I. Miller. 1994. Salmonella stimulate macrophage macropinocytosis and persist within spacious phagosomes. J. Exp Med. 179: 601-608.
57. Ginocchio, C.C., S.B. Olmsted, C.L. Wells, and J.E. Galan. 1994. Contact with epithelial cells induces the formation of surface appendages on Salmonella typhimurium. Cell. 76:717-724.
58. Swanson, J.A. 1989. Phorbol esters stimulate macropinocytosis and solute flow through macrophages. J. Cell Sci. 94:135-142.
59. Marsh, M., and A. Helenius. 1980. Adsorptive endocytosis of Semliki Forest Virus. J. Mol. Biol. 142: 439-454.
60. Racoosin, E.L., and J.A. Swanson. 1993. Macropinosome maturation and fusion with tubular lysosomes in macrophages. J. Cell Biol. 121: 1011-1020.
61. Steinman, R.M., S.E. Brodie, and Z.A. Cohn. 1976. Membrane flow during pinocytosis. A stereologic analysis. T. Cell Biol. 68: 665-687.
62. Hewlett, L.J., A.R. Prescott, and C. Watts. 1994. The coated pit and macropinocytic pathways serve distinct endosome populations. J. Cell Biol. 124: 689-703.