SCOPUS 정보 검색 플랫폼

Volumn 36, Issue 37, 1995, Pages 6623-6626

Kemp’s triacid scaffolding for synthesis of combinatorial nonpeptide uncoded libraries

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXANE DERIVATIVE; PSEUDOPEPTIDE; TRICARBOXYLIC ACID;

ARTICLE; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MASS SPECTROMETRY; STRUCTURE ACTIVITY RELATION;

EID: 0029127055 PISSN: 00404039 EISSN: None Source Type: Journal
DOI: 10.1016/00404-0399(50)1370-W Document Type: Article

Times cited : (57)

References (12)

3
- 84982506235
- The first design and synthesis of a steroidal peptidomimetic. The potential value of peptidomimetics in elucidating the bioactive conformation of peptide ligands
- (1992) Journal of the American Chemical Society , vol.114 , pp. 9699-9701
- Hirschmann, R.¹ Sprengeler, P.A.² Kawasaki, T.³ Leahy, J.W.⁴ Shakespeare, W.C.⁵ Smith, A.B.⁶

4
- 0000615823
- (1981) J. Org. Chem. , vol.46 , pp. 5140-5143
- Kemp, D.S.¹ Petrakis, K.S.²

7
- 53349112702
- Mono-Protected Diamines. N-tert-Butoxycarbonyl-α,ω-Alkanediamines from α,ω-Alkanediamines
- (1990) Synthetic Communications , vol.20 , pp. 2559-2564
- Krapcho, A.P.¹ Kuell, C.S.²

8
- 85024602836
- Attempt to dehydrate amide diacid3 into corresponding amide anhydride4 by reflux in xylene using Dean-Stark trap under argon led to preparation of the tricyclic byproduct 7

9
- 85024609580
- Mono fluorenylmethyloxycarbonylethylenediamine trifluoroacetate was prepared by acylation of mono tert. butyloxycarbonylethylenediamine with 9-fluorenyhnethyl succinimide and subsequent deprotection of Boc group.

12
- 85024609771
- Protocol used for library synthesis: Benzotriazole-l-yl-oxy-tris(dimethylamino)-phosphoniumhexafluoro-phosphate (BOP), Hydroxybenztriazole (HOBt), DIEA (1:1:1.5) activated Boc and Fmoc amino acids were attached to βAla-Gly-βAla-Gly-O-TentaGel. After Fmoc and Boc deprotection by 50% piperidine in DMF for 10 min. and TFA/DCM (1:1), 1 hour, resp. scaffold 5 was coupled to amino acids using BOP activation in situ. The Fmoc of scaffold 5 was removed as above and carboxylic acids were coupled as symmetrical anhydrides (DIC, 30 min. preactivation) and DMAP catalysis. The Boc group of scaffold 5 was removed as above and after neutralization (DIEA) the coupling of carboxylic acids was repeated. After side chain deprotection with mixture K (82.5% TFA, 5% p-cresol, 5% thioanisol, 5% water, and 2,5% ethanedithiol) the library was washed with TFA, DCM, DMF, 0.1% aq. HCl, and 0.02% aq. HCl.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.