Redox signalling by transcription factors NF-κB and AP-1 in lymphocytes

Biochemical Pharmacology

Volumn 50, Issue 6, 1995, Pages 735-741

  Schulze Osthoff, Klaus ^a   Los, Marek ^b   Baeuerle, Patrick A ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

AP 1; lymphocytes; NF B; reactive oxygen intermediates; redox regulation; transcription

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CHELATING AGENT; CYSTEINE; NUCLEAR FACTOR; NUCLEAR FACTOR KB; REACTIVE OXYGEN METABOLITE; TOCOPHEROL DERIVATIVE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

CELL FUNCTION; GENE EXPRESSION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMAL; ANTIOXIDANTS; HUMAN; MOLECULAR SEQUENCE DATA; NF-KAPPA B; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSCRIPTION FACTOR AP-1;

EID: 0029126754     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)02011-Z     Document Type: Article

References (69)

1. The role of free radicals and catalytic metal ions in human disease: An overview
2. −-forming NADPH oxidase from phagocytes: Nature, mechanism of activation and function
3. The superoxidegenerating oxidase of phagocytic cells. Physiological, molecular and pathological aspects
4. Glutathione
5. Functions of glutathione and glutathione disulfide in immunology and immunopathology
6. Oxidized redox state of glutathione in the endoplasmic reticulum
7. Regulation of glutathione levels in mouse spleen lymphocytes by transport of cysteine
8. Low membrane transport activity for cystine in resting and mitogenically stimulated human lymphocyte preparations and human T cell clones
9. Thioredoxin
10. Thioredoxin and glutaredoxin systems
11. Diseases associated with HTLV-I virus, IL-2 receptor dysregulation and redox regulation
12. Biology of disease. Cell and tissue responses to oxidative damage
13. Bacterial defenses against oxidative stress
14. Redox redux: The control of oxidative stress responses
15. Oxygen and the control of gene expression
16. Regulation of gene expression by oxygen in Saccharomyces cerevisiae
17. Active oxygen species in induction of plant systemic acquired resistance by salicylic acid
18. Reactive oxygen species intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1
19. NF-κB and Rel: Participants in a multiform transcriptional regulatory system
20. Function and activation of NF-κB in the immune system
21. An inducible transcription factor activates expression of human immunodeficiency virus in T cells
22. Hydrogen peroxide as a potent activator of T-lymphocyte functions
23. The roles of hydrogen peroxide and Superoxide as messengers in the activation of transcription factor NF-κB
24. Distinct effects of thioredoxin and other antioxidants on the activation of NF-κB and AP-1
25. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation
26. Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF
27. Signal transmission between the plasma membrane and nucleus of T lymphocytes
28. Activation of primary human T lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NF-κB
29. HIV-1 Tat potentiates TNF-induced NF-κB activation and cytotoxicity by altering the cellular redox state
30. + T lymphocytes
31. Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB
32. The ubiquitin-proteasome pathway is required for processing the NF-κB precursor protein and the activation of NFκB
33. A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB
34. Phosphorylation of human IκB-α on serines 32 and 36 controls IκB-α proteolysis and NF-κB activation in response to diverse stimuli
35. Modulation of transcription factor NF-κB binding by oxidation-reduction in vitro
36. The RxxRxRxxC motif conserved in all Rel/κB proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein
37. The stress-activated protein kinase subfamily of c-Jun kinases
38. Redox regulation of a protein tyrosine kinase in the endoplasmic reticulum
39. Hydrogen peroxide preferentially enhances the tyrosine phosphorylation of epidermal growth factor receptor
40. fyn tyrosine kinases in human lymphocytes
41. Ick in T cells
42. NF-κB activation by ultraviolet light not dependent on a nuclear signal
43. Expression of v-src in T cells correlates with nuclear expression of NF-κB
44. Redox activation of Fos-Jun DNA-binding activity is mediated by a DNA repair enzyme
45. The role of Jun, Fos, and the AP-1 complex in cell-proliferation and transformation
46. Rapid and preferential activation of the c-jun gene during the mammalian UV response
47. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor
48. Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia.
49. Hypoxia causes the activation of nuclear factor κB through phosphorylation of IκB-α on tyrosine residues
50. The serum response element
51. Gene regulation by Ets proteins
52. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain
53. Identification of NF-jun, a novel inducible transcription factor that regulates c-jun gene transcription
54. Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes
55. Cross-coupling of the NF-κB p65 and Fos/Jun transcription factors produces potentiated biological function
56. NF-ATp: A transcription factor required for the co-ordinate induction of several cytokine genes
57. Regulation of interleukin 2 production, interleukin 2 mRNA expression and intracellular glutathione levels in ex vivo derived T lymphocytes by lactate
58. Inhibition of murine T-cell responses by anti-oxidants: The targets of lipo-oxygenase pathway inhibitors
59. Antioxidant treatment of thymic organ cultures decreases NF-κB and TCF1α transcription factor activities and inhibits αβ T cell development
60. Hydroxyl radical scavengers inhibit lymphocyte mitogenesis.
61. Antioxidants inhibit proliferation and cell surface expression of receptors for interleukin-2 and transferrin in T lymphocytes stimulated with phorbol myristate acetate and ionomycin
62. Effect of reactive oxygen intermediates and antioxidants on proliferation and function of T lymphocytes
63. Thiol-bearing compounds selectively inhibit protein kinase C-dependent oxidative events and proliferation in human T cells
64. Glutathione augments the activation of cytotoxic T lymphocytes in vivo
65. Requirement of thiol compounds as reducing agents for IL-2-mediated induction of LAK activity and proliferation of human NK cells
66. Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2