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1
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0015514472
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The fluid mosaic model of the structure of cell membranes
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(1972)
Science
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Singer1
Nicolson2
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3
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0027661274
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Protein lateral mobility as a reflection of membrane microstructure
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(1993)
Bioessays
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Zhang1
Lee2
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4
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0021680651
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Lateral diffusion of an 80,000-dalton glycoprotein in the plasma membrane of murine fibroblasts: relationships to cell structure and function
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(1984)
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Jacobson1
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August3
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6
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0024338987
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Nanometre-level analysis demonstrates that lipid flow does not drive membrane glycoprotein movements
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(1989)
Nature
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Sheetz1
Turney2
Qian3
Elson4
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8
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0026528045
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Tracking of cell surface receptors by fluorescence digital imaging microscopy using a charge-coupled device camera. Low-density lipoprotein and influenza virus receptor mobility at 4°C
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(1992)
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Anderson1
Georgiou2
Morrison3
Stevenson4
Cherry5
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9
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0028281482
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Automated detection and tracking of individual and clustered cell surface low density lipoprotein receptor molecules
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(1994)
Biophys J
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Ghosh1
Webb2
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10
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0027197103
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Lateral diffusion in an archipelago. Single-particle diffusion
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(1993)
Biophys J
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Saxton1
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11
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0029162080
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Detection of temporary lateral confinement of membrane proteins using single-particle tracking analysis.
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of special interest, In this paper, we apply the theoretical work of Saxton [10] to our experimental data. The statistical treatment of trajectories from single-particle tracking analysis can aid in distinguishing confined diffusion from simple random walks.
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(1995)
Biophys J
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Simson1
Sheets2
Jacobson3
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13
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33751385662
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Distributions of proteins and lipids in the erythrocyte membrane
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(1993)
Biochemistry
, vol.32
, pp. 12591-12598
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Rodgers1
Glaser2
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15
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0028284608
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Biological applications of optical forces
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of outstanding interest, This outstanding and complete introduction to laser trapping in cell biology describes the current state of the field, the practical set up of a trap, and the theoretical background of optical trapping.
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(1994)
Annu Rev Biophys Biomol Struct
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Svoboda1
Block2
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16
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0026320864
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Lateral movements of membrane glycoproteins restricted by dynamic cytoplasmic barriers
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(1991)
Science
, vol.254
, pp. 1379-1382
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Edidin1
Kuo2
Sheetz3
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17
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0029014265
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Barriers for lateral diffusion of transferrin receptors in the plasma membrane as characterized by receptor dragging by laser tweezers: fence versus tether
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of special interest, of outstanding interest, Transferrin receptors were labelled with either 210 nm latex beads or 40 nm colloidal gold and dragged along the surfaces of fibroblasts with a laser trap. The magnitude of the barrier-free paths decreased as the trapping force decreased, and agreed well with the domain size determined by single particle trapping for this protein [19]. The rebound that was observed upon escape from the laser trap suggested that the barriers are elastic structures.
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(1995)
J Cell Biol
, vol.129
, pp. 1559-1574
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Sako1
Kusumi2
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18
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0027504198
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Confined lateral diffusion of membrane receptors as studied by single particle tracking (nanovid microscopy). Effects of calcium-induced differentiation in cultured epithelial cells
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(1993)
Biophys J
, vol.65
, pp. 2021-2040
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Kusumi1
Sako2
Yamamoto3
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19
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0028243194
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Compartmentalized structures of the plasma membrane for receptor movements as revealed by a nanometer-level motion analysis
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of special interest, This paper provides additional support for the membrane—skeleton fence proposed in [18]. Partial destruction of the cytoskeleton decreases the fraction of membrane proteins exhibiting confined diffusion and increases the fraction undergoing random diffusion.
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(1994)
J Cell Biol
, vol.125
, pp. 1251-1264
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Sako1
Kusumi2
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20
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0019190475
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Lateral mobility of band 3 in the human erythrocyte membrane studied by fluorescence photobleaching recovery: evidence for control by cytoskeletal interactions
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(1980)
Proc Natl Acad Sci USA
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, pp. 2537-2541
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Golan1
Veatch2
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21
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0020790863
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Membrane skeletal dynamics: role in modulation of red cell deformability, mobility of transmembrane proteins, and shape
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(1983)
Semin Hematol
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Sheetz1
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22
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0022966969
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Restriction of the lateral motion of band 3 in the erythrocyte membrane by the cytoskeletal network: dependence on spectrin association state
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(1986)
Biochemistry
, vol.25
, pp. 6133-6139
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Tsuji1
Ohnishi2
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23
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0028325756
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Truncation mutants define and locate cytoplasmic barriers to lateral mobility of membrane glycoproteins
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of special interest, Major histocompatibility complex proteins with varying lengths of cytoplasmic domains were used to probe the properties of the barriers to diffusion observed by laser trapping and fluorescence recovery after photobleaching. A length of seven residues in the cytoplasmic tail was found to be the critical length necessary for significant restriction of diffusion, corresponding to a calculated separation distance of 2–3 nm between the membrane and barriers.
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(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 3378-3382
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Edidin1
Zúñiga2
Sheetz3
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24
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0028141959
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Differential control of band 3 lateral and rotational mobility in intact red cells.
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of outstanding interest, An excellent study in which both lateral and rotational mobility of band 3 were measured on matched samples of erythrocytes from controls and patients with hereditary hemolytic anemias. This paper provides additional support for the membrane-skeleton fence model by showing that the lateral diffusion of band 3 increases as the spectrin content decreases (in the genetic disorders), whereas the rotational diffusion remains unaffected.
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(1994)
Journal of Clinical Investigation
, vol.94
, pp. 683-688
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Corbett1
Agre2
Palek3
Golan4
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25
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0028140412
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Anomalous diffusion due to obstacles: a Monte Carlo study
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of special interest, In this paper, Saxton uses Monte Carlo simulations to characterize anomalous lateral diffusion (that is, non-classical diffusion in which the mean squared displacemnt is proportional to some fractional power of time that is less that one) for a wide range of obstacle concentrations. The sampling time for the experiment and the obstacle concentration will largely determine whether anomalous diffusion can be detected. Saxton also discusses the importance of averaging trajectories from single particle tracking experiments to minimize the effects of statistical fluctuations on the detection of anomalous diffusion.
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(1994)
Biophysical Journal
, vol.66
, pp. 394-401
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Saxton1
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26
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0028352175
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Large-scale co-aggregation of fluorescent lipid probes with cell surface proteins
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of special interest, The fluorescent lipid, 3,3'-dihexadecylindocarbocyanine (dil), colocalized with cross-linked IgE receptor and was immobilized in a fluorescence recovery after photobleaching assay in much larger proportion than the area occupied by IgE receptor. The mechanism of immobilization probably involves generating large ‘rafts’ of closely spaced obstacles that measurably retard the diffusion of the dil probe.
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(1994)
J Cell Biol
, vol.125
, pp. 795-802
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Thomas1
Holowka2
Baird3
Webb4
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27
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44049110023
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Interactions between GPI-anchored proteins and membrane lipids
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(1992)
Trends Cell Biol
, vol.2
, pp. 338-343
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Brown1
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28
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0028151351
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Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior
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of outstanding interest, The insolubility of detergent-resistant membrane fractions (which have been found in previous studies to be enriched in glycosylphosphatidylinositol [GPI]-anchored proteins, cholesterol, and glycosphingolipids) was shown to be dependent upon the fluidity of the lipids comprising these fractions. Interactions between GPI-anchored proteins and the acyl chains of the lipids may promote a highly ordered, non-liquid crystalline state that induces detergent insolubility. These associations also suggest a possible membrane-localizing mechanism for GPI-anchored proteins.
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(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 12130-12134
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Schroeder1
London2
Brown3
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29
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0027445508
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Proteins associated with the cytoplasmic surface of adhesion molecules
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(1993)
Neuron
, vol.11
, pp. 551-564
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Gumbiner1
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30
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0028029162
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Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin
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of special interest, A cell adhesion molecule (CAM) homology domain was identified in the fibroblast growth factor (FGF) receptor. Anti-CAM antibodies and CAM-domain peptides could inhibit neurite outgrowth that was stimulated by CAMs. Also, soluble CAMs were found to stimulate the FGF receptor pathway.
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(1994)
Neuron
, vol.13
, pp. 583-594
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Williams1
Furness2
Walsh3
Doherty4
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31
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0028963771
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Alteration of lipid composition modulates FcεRI signaling in RBL-2H3 cells
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of special interest, The activity of a protein kinase C like pathway that is important in FcεRI degranulation increases when the cholesterol: phospholipid ratio decreases. This work suggests that lipid composition may be involved in regulating signaling pathways.
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(1995)
Biochemistry
, vol.34
, pp. 4376-4384
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Chang1
Zheng2
Holowka3
Baird4
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32
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0026036062
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Mapping trajectories of Pgp-1 membrane protein patches on surfaces of motile fibroblasts reveals a distinct boundary separating capping on the lamella and forward transport on the retracting tail
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(1991)
J Cell Sci
, vol.98
, pp. 191-203
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Holifield1
Jacobson2
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34
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0027970208
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Single particle tracking of surface receptor movement during cell division
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of special interest, This paper presents the first mapping of the motion of concanavalin A and fibronectin receptors during cell division. These movements reflect the underlying actin contractile activity that occurs during cytokinesis. The fluorescent beads moved in a concerted manner toward the equator following the onset of anaphase and accelerated as the chromosomes passed under them.
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(1994)
J Cell Biol
, vol.127
, pp. 963-971
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Wang1
Silverman2
Cao3
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35
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0024375302
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Forward transport of glycoproteins on leading lamellipodia in locomoting cells
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(1989)
Nature
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Kucik1
Elson2
Sheetz3
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38
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0027941405
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Microtubule inhibitors differentially affect translational movement, cell surface expression, and endocytosis of transferrin receptors in K562 cells
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of special interest, Long-term incubation with microtubule-disrupting drugs on erythroleukemia cells lead to the immobilization of the transferrin receptor but did not affect glycophorin or lipid mobilities. This result prompts the suggestion that drug-resistant microtubules somehow direct the lateral transport of the transferrin receptor.
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(1994)
J Cell Physiol
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, pp. 345-357
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Thatte1
Bridges2
Golan3
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39
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0025647334
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Comparative behavior of membrane protein—antibody complexes on motile fibroblasts: implications for a mechanism of capping
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(1990)
J Cell Biol
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, pp. 2499-2512
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Holifield1
Ishihara2
Jacobson3
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41
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0019501294
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Lateral diffusion of surface molecules in animal cells and tissues
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(1981)
Science
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Gall1
Edelman2
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43
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0027452755
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Forward plasma membrane flow in growing nerve processes
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(1993)
Science
, vol.259
, pp. 244-246
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Popov1
Brown2
Poo3
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44
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0028101021
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Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cells
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(1994)
J Cell Biol
, vol.126
, pp. 1509-1526
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Reinsch1
Karsenti2
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48
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0028129695
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Induction of polarized cell—cell association and retardation of growth by activation of the E-cadherin—catenin adhesion system in a dispersed carcinoma line
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(1994)
J Cell Biol
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, pp. 247-256
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Watabe1
Nagafuchi2
Tsukita3
Takeichi4
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49
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0017256709
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Surface modulation in cell recognition and cell growth. Some new hypotheses on phenotypic alteration and transmembranous control of cell surface receptors
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(1976)
Science
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Edelman1
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50
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0021237244
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Mobility modulation by local concanavalin A binding. Selectivity toward different membrane proteins
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(1984)
J Biol Chem
, vol.259
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Henis1
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51
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0028330803
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Cooperative action between band 3 and glycophorin A in human erythrocytes: immobilization of band 3 induced by antibodies to glycophorin A
-
of outstanding interest, The binding of monoclonal anti-glycophorin A markedly increased red cell rigidity and immobilized both glycophorin A and band 3. Red cells expressing mutant glycophorins with no cytoplasmic domains did not show these effects, indicating the importance of glycophorin—cytoskeleton interactions. These experiments demonstrate the polymorphic physical effects that a particular ligand—receptor combination can stimulate.
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(1994)
Biophys J
, vol.66
, pp. 1726-1732
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Knowles1
Chasis2
Evans3
Mohandas4
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52
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0028901486
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Loss of rotational mobility of band 3 proteins in human erythrocyte membranes induced by antibodies to glycophorin A
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(1995)
Biophys J
, vol.68
, pp. 1881-1887
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Che1
Cherry2
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53
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0027172919
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Mechanotransduction across the cell surface and through the cytoskeleton
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(1993)
Science
, vol.260
, pp. 1124-1127
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Wang1
Butler2
Ingber3
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54
-
-
0028954797
-
Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function
-
of outstanding interest, Latex beads that were coated with RGD peptide ligands, adhesion inhibitory antibodies or non-inhibitory antibodies were used to probe the effects of oligomerization and occupancy on integrin clustering and focal adhesion assembly. Monovalent ligands, such as soluble RGD peptides, induced integrin redistribution but limited both accretion of cytoplasmic components and tyrosine phosphorylation. In contrast, multivalent non-inhibitory antibodies coated on 5 μm beads induced the accumulation of tensin and focal adhesion kinase (but no other cytoskeletal components) under the beads. However, this antibody on beads plus soluble RGD peptides induced both accumulation of seven cytoskeletal proteins under the beads and phosphorylation. Thus, the regulation of integrin function in vivo could depend upon a combination of receptor occupancy and aggregation selected by the local environment.
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(1995)
Science
, vol.267
, pp. 883-885
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Miyamoto1
Akiyama2
Yamada3
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55
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-
0027938023
-
Molecular maps of red cell deformation: hidden elasticity and in situ connectivity
-
of outstanding interest, An excellent study demonstrating how red cell membrane components are redistributed in response to micropipet aspiration. By examining the fluorescence intensity profiles of the cell body both outside of the micropipet and the projection within, the authors showed that the distribution of lipids in the plasma membrane was uniform. However, the density of the cytoskeletal fluorescence decreased with increased projection length, similar to that observed with cytoskeleton-associated membrane proteins (band 3 and glycophorin C). In contrast, glycosylphosphatidylinositol-anchored and other mobile proteins exhibited a steric-based segregation (i.e. they were enriched at the tip of the projection).
-
(1994)
Science
, vol.266
, pp. 1032-1035
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-
Discher1
Mohandas2
Evans3
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56
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0028943834
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Mechanical properties of neuronal growth cone membranes studied by tether formation with laser optical tweezers
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(1995)
Biophys J
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, pp. 988-996
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Dai1
Sheetz2
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59
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0028532360
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Underwater performance of flexible microgripper and fine particle manipulation
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(1994)
Jpn J Appl Phys
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Suzuki1
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60
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0027715822
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The riddle of morphogenesis: a question of solution chemistry or molecular cell engineering?
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(1993)
Cell
, vol.75
, pp. 1249-1252
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Ingber1
-
61
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0028364295
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Biomolecular imaging with the atomic force microscope
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of outstanding interest, This helpful review describes the current state of biological atomic force microscopy, instrumentation, and image interpretation.
-
(1994)
Annu Rev Biophys Biomol Struct
, vol.23
, pp. 115-139
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-
Hansma1
Hoh2
-
65
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0028945654
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Imaging of single fluorescent molecules and individual ATP turnovers by single myosin molecules in aqueous solution
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of outstanding interest, In a most elegant study, the turnover time of ATP on single myosin molecules was measured by detecting the co-localized fluorescence of individual ATP and myosin molecules.
-
(1995)
Nature
, vol.374
, pp. 555-559
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-
Funatsu1
Harada2
Tokunaga3
Saito4
Yanagida5
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