The structure of calcyclin reveals a novel homodimeric fold for s100 ca2+-binding proteins

Nature Structural Biology

Volumn 2, Issue 9, 1995, Pages 790-796

  Potts, Barbara C M ^a   Smith, Jarrod ^a   Akkeu, Mikael ^a,b   Macke, Thomas J ^a   Okazaki, Katsuo ^c   Hidaka, Hiroyoshi ^c   Case, David A ^a   Chazin, Walter J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM BINDING PROTEIN; CALCYCLIN; PROTEIN S 100; UNCLASSIFIED DRUG;

CALCIUM TRANSPORT; DIMERIZATION; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; THREE DIMENSIONAL IMAGING;

AMINO ACID SEQUENCE; ANIMAL; CALCIUM-BINDING PROTEINS; CATTLE; HUMAN; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN FOLDING; RABBITS; S100 PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SOLUTIONS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0029125084     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb0995-790     Document Type: Article

References (47)

1. Donato, R. Perspectives in S-100 protein biology. Cell Calc. 12, 713-726 (1991).
2. Hilt, D.C. and Kligman, D. in The S-100 protein family: a biochemical and functional overview. Novel calcium-binding proteins, (ed. C.W. Heizmann) 65-103 (Springer-Verlag, New York, 1991).
3. Engelkamp, D., Schafer, B.W., Mattei, M.G., Erne, P. and Heizmann, C.W. Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding protein S100D and SIOOE. Proc. natn. Acad. Sci. U.S.A. 90, 6547-6551 (1993).
4. Schafer, B.W., Wicki, R., Engelkamp, D., Mattei, M.G. and Heizmann, C.W. Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family Genomics 25, 638-643 (1995).
5. Calabretta, B. et al. Cell-cycle-specific genes differentially expressed in human leukemias. Proc. natn. Acad. Sci. U.S.A. 82, 4463-4467 (1985).
6. Calabretta, B. et al., Altered expression of G,-specific genes in human myeloid cells. Proc. natn. Acad. Sci. U.S.A. 83, 1495-1498 (1996).
7. Murphy, L.C., Murphy, L.J., Tsuyuki, D., Duckworth, M.L. and Shiu, R.P.C. Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an antiprolactin receptor antiserum. 1. biol. Chem. 263, 2397-2401 (1988).
8. Hirschhorn, R.R., Aller, P, Yuan, Z., Gibson, C.W. and Baserga, R. Cell-cycle-specific cDNAs from mammalian cells temperature sensitive for growth. Proc. natn. Acad. Sci. U.S.A. 81, 6004-6008 (1984).
9. Ferrari, S. et al., Structural and functional analysis of a growth- regulated gene, the human calcydin. 7. biol. Chem. 262, 8325-8332 (1978).
10. Tokumitsu, H., Mizutani, A., Minami, H., Kobayashi, R. and Hidaka, H. A calcyclin-associated protein is a newly identified member of the CaWphosphollpid-binding proteins, annexin family J. biol. Chem. 267, 8919-8924 (1992).
11. Mlnaml, H. etal., Specific binding of CAP-50 to calcydin. FEBS Lett. 305, 217-219 (1992).
12. Tokumitsu, H., Mizutani, A. and Hidaka, H. Calcydin-binding site located on the NH2-terminal domain of rabbit CAP-50 (annexin XI): functional expression of CAP-50 in Escherichia coli. Arch, biochem. Biophys. 303, 302-306 (1993).
13. Mizutani, A. etal., CAP-50, a newly identified annexin, localizes in nuclei of cultured fibroblast 3Y1 cells. 7. biol. Chem. 267, 13498-13504 (1992).
14. Baudier, J. and Cole, R.D. Interactions between the microtubule- associated x proteins and SI00b regulate x phosphorylation by the Ca2V calmodulin-dependent protein kinase II. J. biol. Chem. 263, 5876-5883 (1989).
15. Gerke, V. and Weber, K.The regulatory chain in the p36-kd substrate complex of viral tyrosine-specific proteins is related in sequence to the S-100 protein of glial cells. EMBOJ. 4, 2917-2920 (1985).
16. Glenney Jr., J.R. and Tack, B.F. Amino-terminal sequence of p36 and associated p 10: identification of the site of tyrosine phosphorylation and homology with S-100. Proc. natn. Acad. Sci. U.S.A. 82, 7884- 7888 (1985).
17. McPhalen, C.A., Strynadka, N.C. and James, M.N. Calcium-binding sites in proteins: a structural perspective. Adv. Prof. Chem. 42, 77-144 (1991).
18. Szebenyi, D.M.E. and Moffat, K. The refined structure of vitamin D- dependent calcium-binding protein from bovine intestine. Molecular details, ion binding, and implications for the structure of other calciumbinding proteins. J. biol. Chem. 261, 8761-8777 (1986).
19. Svensson, L.A., Thulin, E. and Forsen, S. Proline cis-trans isomers in calbindin D9k observed by X-ray crystallography. J. molec. Biol. 223, 601-606 (1992).
20. Kordel, J., Skelton, N.J., Akke, M. and Chazln, W.J. High-resolution solution structure of calcium-loaded calbindin D9k. J. molec. Biol. 231, 711-734 (1993).
21. Skelton, N.J., Kordel, J., and Chazin, W.J. Determination of the solution structure of apo calbindin Dsk by NMR spectroscopy. J. molec. Biol. 249, 441-462 (1995).
22. Wuthrich, K. Protein structure determination in solution by nuclear magnetic resonance spectroscopy. Science 243, 45-50 (1989).
23. Barger, S.W., Wolchok, S.R. and Van Eldik, L.J. Disulfide-linked S100 (3 dimers and signal transduction. Biochim. biophys. Acta 1160, 10S- 112 (1992).
24. Teigelkamp, S. et al., Calcium-dependent complex assembly of the myeloic differentiation proteins MRP-8 and MRP-14. 7. biol. Chem. 266, 13462-13467 (1991).
25. Gerke, V. and Weber, K. Calcium-dependent conformational changes in the 36-kDa subunit of intestinal protein I related to the cellular 36-kDa target of Rous sarcoma virus tyrosine kinase. J. biol. Chem. 260, 1688-1695 (1985).
26. Dell'Angelica, E.C., Schleicher, C.H. and Santome, J.A. Primary structure and binding properties of calgranulin C, a novel SI00-like calcium-binding protein from pig granulocytes. J. biol. Chem. 269, 28929-28936 (1994).
27. Pedrocchi, M., Schafer, B.W., Durussel, I., Cox, J.A. and Heizmann, C.W. Purification and characterization of the recombinant human calcium-binding S100 proteins CAPLand CACY. Biochemistry 33, 6732- 6738 (1994).
28. Skelton, N.J., Kordel, J., Forsen, S. and Chazin, W.J. Comparative structural analysis of the calcium free and bound states of the calcium regulatory protein calbindin D9k. 7. molec. Biol. 213, 539-598 (1990).
29. Kilby, P.M., Van Eldik, L.J. and Roberts, G.C.K. Nuclear magnetic resonance assignments and secondary structure of bovine S100 3 protein. FEBS Lett. 363, 90-96 (1995).
30. Crivici, A. and Ikura, M. Molecular and structural basis of target recognition by calmodulin. A. Rev. Biophys. biomol. Struct. 24, 85116 (1995).
31. Wojda, U. and Kuznicki, J. Calcydin from mouse Ehrlich ascites tumor cells and rabbit lung form non-covalent dimers. Biochim. biophys. Acta 1209, 248-252 (1994).
32. Kuznicki, J., Filipek, A., Hunziker, P, Huber, S. and Heizmann, C.W. Calcium-binding protein from mouse Ehrlich ascites-tumour cells is homologous to human calcydin. Biochem. J. 263, 951-956 (1989).
33. Ando, Y., Watanabe, M., Akatsuka, H., Tokumitsu, H. and Hidaka, H. Site-directed mutation makes rabbit calcydin dimer. FEBS Lett. 314, 109-113 (1992).
34. Johnsson, N. and Weber, K. Alkylation of cysteine 82 of p11 abolishes the complex formation with the tyrosine-protein kinase substrate p36 (annexin 2, calpactin 1, lipocortin 2). J. biol. Chem. 265, 14464-14468 (1990).
35. Kube, E., Becker, T, Weber, K. and Gerke, V. Protein-protein interaction studied by site-directed mutagenesis. Characterization of the annexin ll-binding site on p11, a member of the S100 protein family. J. biol. Chem. 267, 14175-14182 (1992).
36. Tokumitsu, H., Kobayashi, R. and Hidaka, H. A calcium-binding protein from rabbit lung cytosol identified as the product of a growth- regulated gene (2A9) and its binding proteins. Arch, biochem. Biophys. 288, 202-207 (1991).
37. Ludvigsen, S. and Poulsen, F.M, Positive -angles in proteins by nuclear magnetic resonance spectroscopy. J. biomol. NMR 2, 227-233 (1992).
38. Pearlman, D.A., Case, D.A., Yip, P. SANDER/AMBER 4.0. San Francisco, University of California, 1991.
39. Weiner, S J., Kollman, P.A., Nguyen, D.T., and Case, D.A. An allatom force field for simulations of proteins and nucleic acids. 7. comput. Chem. 7, 230-252 (1986).
40. Connolly, M.L. Solvent-accessible surfaces of proteins and nucleic acids. Science 221, 709-713 (1983).
41. Chothia, C., Levitt, M. and Richardson, D. Helix to helix packing in proteins. 7. molec. Biol. 145, 215-250 (1981).
42. Duncan, B., Macke, T. and Olson, A. Biomolecular visualization using AVS. 7. molec. Graphics, in the press.
43. Duncan, B., Pique, M. and Olson, A. AVS for molecular modeling. Proc. AVSConf. (1993).
44. Strynadka, N.C.J. and James, M.N.G. Crystal structures of the helixloop-helix calcium-binding proteins. A. Rev. Biochem. 58, 951-998 (1999).
45. Kawasaki, H. and Kretsinger, R.H. Calcium-binding proteins 1: EF- hands. Protein Profile 1, 343-517 (1994).
46. Carsen, M. Ribbons 2.0. 7. appl. Crystallogr. 24, 958-961 (1991).
47. Sanner, M.F., Olson, A.J. and Spehner, J.C. Fast and robust computation of molecular surfaces. Proc. 11th ACM Symp. comp. Geom. C6-C7 (1995).