Enzymatic oxidation of the dopaminergic neurotoxin, 1 (R), 2(N)-Dimethyl-6,7-Dihydroxy-l,2,3,4-Tetrahydroisoquinoline, into 1,2(N)-Dimethyl-6,7-Dihydroxyisoquinolinium ion

Life Sciences

Volumn 57, Issue 11, 1995, Pages 1061-1066

  Naoi, Makoto ^a   Maruyama, Wakako ^b   Zhang, Jian Hua ^a   Takahashi, Tsutomu ^c   Deng, Yulin ^a   Dostert, Philippe ^d  

^a NAGOYA INSTITUTE OF TECHNOLOGY   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KONAN WOMEN'S UNIVERSITY   (Japan)

^d Department of Food and Nutrition Konan Women's College ^*  (Italy)

Author keywords

1; 2 dimethyl 6; 7 dihydroxy isoquinolinium; N methylsalsolinol; semicarbazide sensitive oxidase

Indexed keywords

1 METHYLSALSOLINOL; ALKALOID; AMINE OXIDASE (FLAVIN CONTAINING); NEUROTOXIN; QUINOLINE DERIVATIVE; SALSOLINOL; SEMICARBAZIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOPAMINERGIC SYSTEM; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; METABOLITE; NEUROTOXICITY; OXIDATION;

CELL COMPARTMENTATION; CEREBRAL CORTEX; CLORGYLINE; HUMAN; IN VITRO; ISOQUINOLINES; KINETICS; NEUROTOXINS; OXIDATION-REDUCTION; SELEGILINE; SEMICARBAZIDES; SUPPORT, NON-U.S. GOV'T;

EID: 0029124292     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/0024-3205(95)02051-J     Document Type: Article

References (20)

1. Influence of food intake on the enantiomeric composition of urinary salsolinol in man
2. N-methyl(R)salsolinol produces hydroxyl radicals: involvement to neurotoxicity.
3. J. Neural Transm.
4. Dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines; oxidation and neurotoxicity.
5. J. Neural Transm.