Propionyl L-carnitine improvement of hypertrophied heart function is accompanied by an increase in carbohydrate oxidation

Circulation Research

Volumn 77, Issue 4, 1995, Pages 726-734

  Schönekess, Brett O ^a   Allard, Michael F ^b   Lopaschuk, Gary D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b ST PAUL S HOSPITAL   (Canada)

Author keywords

fatty acid oxidation; glucose oxidation; glycolysis; myocardial hypertrophy; propionyl L carnitine

Indexed keywords

PROPIONYLCARNITINE; PYRUVATE DEHYDROGENASE;

ANIMAL TISSUE; ARTICLE; CARBOHYDRATE ANALYSIS; CARBOHYDRATE METABOLISM; FATTY ACID OXIDATION; GLYCOLYSIS; HEART HYPERTROPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029124119     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.77.4.726     Document Type: Article

References (33)

1. Frohlich ED, Chobanian AV, Devereux RB, Dustan HP, Dzav V, Faud-Tarazi F, Horan MJ, Marcos M, Massie B, Pfieffer RN, Re EJ, Roccelal D, Savage D, Shub C. The heart in hypertension. N Engl J Med. 1992;327:998-1008.
2. Weber JR. Left ventricular hypertrophy: its prime importance as a controllable risk factor. Am Heart J. 1988;116:272-279.
3. 31P-MRS study. Cur Res. 1990;66:735-746.
4. Hearse DJ, Stewart DA, Green DG. Myocardial susceptibility to ischemic damage: a comparative study of disease models in the rat. Eur J Cardiol. 1978;7:437-450.
5. Anderson PG, Allard MF, Thomas GD, Bishop SP, Digerness SB. Increased ischemic injury hut decreased hypoxic injury in hypertrophied rat hearts. Circ Res. 1990;67:948-959.
6. Bishop SP, Aultschuld RA. Evidence for increased glycolytic metabolism in cardiac hypertrophy and congestive heart failure. In: Alpert N, ed. Cardiac Hypertrophy. New York, NY: Academic Press Inc; 1971:567-585.
7. Ingwall JS. The hypertrophied myocardium accumulates the MB-creatine kinase isozyme. Eur Heart J. 1984;5(suppl F):129-139.
8. Taegtmeyer H, Overturf ML. Effects of moderate hypertension on cardiac function and metabolism in the rabbit. Hypertension. 1988; 11:416-426.
9. Cunningham MJ, Apstein CS, Weinberg EO, Vogel WM, Lorell BH. Influence of glucose and insulin on the exaggerated diastolic and systolic dysfunction of hypertrophied rat hearts during hypoxia. Circ Res. 1990;66:406-415.
10. El Alaoui-Talibi Z, Landormy S, Loireau A, Moravec J. Fatty acid oxidation and mechanical performance of volume-overloaded rat hearts. Am J Physiol (Lond). 1992;262:H1068-H1074.
11. 31P magnetic resonance. J Clin Invest. 1992;89: 909-918.
12. Allard MF, Schönekess BO, Henning SL, English DR, Lopaschuk GD. The contribution of oxidative metabolism and glycolysis to ATP production in the hypertrophied heart. Am J Physiol. 1994;267: H742-H750.
13. Motterlini R, Samaja M, Tarantola M, Micheletti R, Bianchi G. Functional and metabolic effects of propionyl-L-carnitine in the isolated perfused hypertrophied rat heart. Mol Cell Biochem. 1992; 116:139-145.
14. Yang XP, Samaja M, English E, Benatti P, Tarantola M, Cardace G, Motterlini R, Michelliti R, Bianchi G. Hemodynamic and metabolic activities of propionyl-L-carnitine in rats with pressure-overload cardiac hypertrophy. J Cardiovasc Pharmacol. 1992;20: 88-98.
15. Michelletti R, Giacalone G, Canepari M, Salardi S, Bianchi G, Reggiani C. Propionyl L-carnitine prevents myocardial mechanical alterations due to pressure overload in rats. Am J Physiol. 1994;266: H2190-H2197.
16. Cheikh RB, Guendouz A, Moravec J. Control of oxidalive metabolism in volume-overloaded rat hearts: effects of different lipid substrates. Am J Physiol. 1994;266:H2090-H2097.
17. Riehel DK, Uboh CE, Kent RL. Altered coenzyme A and carnitine metabolism in pressure-overload hypertrophied hearts. Am J Physiol. 1983;244:H839-H843.
18. Paulson DJ, Traxler J, Schmidt M, Noonan J, Shug AL. Protection of the ischemic myocardium by L-propionylcarnitine: effects on the recovery of cardiac output after ischaemia and reperfusion, carnitine transport, and fatty acid oxidation. Cardiovasc Res. 1986;20: 536-541.
19. Davies EJ, Spydcrold O, Bremer J. Pyruvate carboxylase and propionyl-CoA carboxylase as anaplerotic enzymes in skeletal muscle mitochondria. Eur J Biochem. 1980;110:255-262.
20. Tassani V, Cattapan F, Magnanimi L, Pescherchera A. Anaplerotic effect or propionyl carnitine in rat heart mitochondria. Biochem Biophys Res Commun. 1994;199:949-953.
21. Bartels GL, Remme WJ, Pillay M, Schönfeld DHW, Cox PH, Kruijssen HACM, Knufman NMJ. Acute improvement of cardiac function with intravenous L-propionylcarnitine in humans. J Cardiovasc Pharmacol. 1992;20:157-164.
22. Liedtke AJ, DeMaison L, Nellis SH. Effects of L-propionylcarnitine on mechanical recovery during reflow in intact hearts. Am J Physiol. 1988;255:H169-H176.
23. Broderick TL, Quinney HA, Lopaschuk GD. Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart. J Biol Chem. 1992;267:3758-3763.
24. Broderick TL, Quinney HA, Barker CC, Lopaschuk GD. Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation. Circulation. 1993;87:972-981.
25. Lysiak W, Lilly K, DiLisa F, Toth PP, Bieber LL. Quantification of the effect of L-carnitine on the levels of acid-soluble short-chain acyl CoA and CoA in rat heart and liver mitochondria. J Biol Chem. 1988;263:1511-1516.
26. Schönekess BO, Allard MF, Lopaschuk GD. Hydrogen production from glucose metabolism in hypertrophied hearts. Can J Cardiol. 1994;19(suppl A):98A. Abstract.
27. Lopaschuk GD, Wambolt RB, Barr RL. An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic perfusion of ischemic hearts. J Pharmacol Exp Ther. 1993;264:135-144.
28. Saddik M, Lopaschuk GD. Myocardial triglyceride turnover and contribution to energy substrate utilization in isolated working rat hearts. J Biol Chem. 1991;266:8162-8170.
29. McGarry JD, Foster DW. An improved and simplified rudioisotope assay for the determination of free and esterified carnitine. J Lipid Res. 1976;17:277-281.
30. Neely JR, Whitmer KM, Mochizuki S. Effects of mechanical activity and hormones on myocardial glucose and fatty acid utilization. Circ Res. 1976;38(suppl I):I-22-I-30.
31. Broderick TL, Christos BA, Wolf BA, DiDomenico D, Shug AL, Paulson DJ. Fatty acid oxidation and cardiac function in the sodium pivalate model of secondary carnitine deficiency. Metabolism. In press.
32. Opie LH. Myocardial ischemia-metabolic pathways and implications of increased glycolysis. Cardiovasc Drugs Ther. 1990;4: 777-790.
33. + exchange system. Circ Res. 1993;74:794-805.