Developmental neurotoxicity of chlorpyrifos: Cellular mechanisms

Toxicology and Applied Pharmacology

Volumn 134, Issue 1, 1995, Pages 53-62

  Whitney, K D ^a   Seidler, F J ^a   Slotkin, T A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPYRIFOS; MECAMYLAMINE; NICOTINIC RECEPTOR; PESTICIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN DEVELOPMENT; BRAIN STEM; CELL MATURATION; CEREBELLUM; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; FOREBRAIN; MORTALITY; NEUROTOXICITY; NEWBORN; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; RAT;

ANIMAL; ANIMALS, NEWBORN; BODY WEIGHT; BRAIN; CHLORPYRIFOS; DNA; MECAMYLAMINE; ORGAN WEIGHT; ORNITHINE DECARBOXYLASE; PROTEINS; RATS; RECEPTORS, NICOTINIC; SUPPORT, U.S. GOV'T, NON-P.H.S.;

EID: 0029123631     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1006/taap.1995.1168     Document Type: Article

References (52)

1. Anderson-Brown, T., Slotkin, T. A., and Seidler, F. J. (1990). Cocaine acutely inhibits DNA synthesis in developing rat brain regions: Evidence for direct actions. Brain Res. 537, 197-202.
2. Bell, J. M., and Lundberg, P. K. (1985). Effects of a commercial soy lecithin preparation on development of sensorimotor behavior and brain biochemistry in the rat. Dev. Psychobiol. 18, 59-66.
3. Bell J. M., and Slotkin, T. A. (1985). Perinatal dietary supplementation w ith a commercial soy lecithin preparation: Effects on behavior and brain biochemistry in the developing rat. Dev. Psychobiol. 18, 383-394.
4. Bell, J. M., Whitmore, W. L., Queen, K. L., Orband-M 111er, L., and Slotkin, T. A. (1987). Biochemical determinants of growth sparing during neonatal nutritional deprivation or enhancement: Ornithine decarboxylase, polyamines, and macromolecules in brain regions and heart. Pediutr. Res. 22, 599-604.
5. Bell J. M., Whitmore W. L., and Slotkin, T. A. (1986). Effects of a-difluoromelhylornithine. a specific irreversible inhibitor of ornithine decarboxylase, on nucleic acids and proteins in developing rat brain: Critical perinatal periods for regional selectivity. Neuroscience 17, 399-407.
6. Burry, R. W. (1985). Protein synthesis requirement for the formation of synaptic elements. Brain Res. 344, 109-119.
7. Butler, S. R., Suskind M. R., and Schanberg, S. M. (1978). Maternal behavior as a regulator of polyamine biosynthesis in brain and heart of the developing rat pup. Science 199, 445-447.
8. Buznikov, G. A., Kost, A. N., and Berdysheva L. V. (1970). The role of neurohumours in early embryogenesis. 3. Pharmacological analysis of the role of neurohumours in cleavage divisions. J. Embryol. Exp. Mor-phol. 23, 549-569.
9. Cairns, N. J., and Wonnacott, S. (1988). [3H](-)nicotine binding sites in fetal human brain. Brain Res. 475, 1-7.
10. Carlos, R. Q., Seidler, F. J., and Slotkin, T. A. (1991). Fetal dexamethasone exposure sensitizes neonatal rat brain to hypoxia: Effects on protein and DNA synthesis. Dev. Brain Res. 64, 161-166.
11. Carlos, R. Q., Seidler, F. J., and Slotkin, T. A. (1992). Fetal dexamethasone exposure alters macromolecular characteristics of rat brain development: A critical period for regionally-selective alterations? Teratology 46, 45-59.
12. Chakraborti, T. K., Farrar, J. D., and Pope, C. N. (1993). Comparative neurochemical and neurobehavioral effects of repeated chlorpyrifos exposures in young and adult rats. Pharmacol. Biochem. Behav. 46, 219-224.
13. Chambers, J. E., and Carr, R. L. (1993). Inhibition patterns of brain acetylcholinesterase and hepatic and plasma aliesterases following exposures to three phosphorothionate insecticides and their oxons in rats. Fund. Appl. Toxicol. 21, 111-119.
14. Claycomb, W. C. (1976). Biochemical aspects of cardiac muscle differentiation. J. Biol. Chem. 251, 6082-6089.
15. De Peyster, A., W 111is, W. O., Molgaard, C. A., MacKendrick, T. M., and Walker, C. (1993). Cholinesterase and self-reported pesticide exposure among pregnant women. Arch. Environ. Health 48, 348-352.
16. Dobbing, J., and Sands, J. (1979). Comparative aspects of the brain growth spurt. Early Hum. Dev. 3, 79-83.
17. Duncan, C. P., Seidler, F. J., Lappi, S. E., and Slotkin, T. A. (1990). Dual control of DNA synthesis by a-and B-adrenergic mechanisms in normoxic and hypoxic neonatal rat brain. Dev. Brain Res. 55, 29-33.
18. Edblagh, M., Tonge, D., Golding, J., Ekstrom, A. R., and Edstrom, A. (1994). Early regeneration in vitro of adult mouse sciatic axons is dependent on local protein synthesis but may not involve neurotrophins. Neu-rosci. Lett. 168, 37-40.
19. Fenske, R. A., Black, K. G., Elkner, K. P., Lee, C., Methner, M. M., and Soto, R. (1990). Potential exposure and health risks of infants following indoor residential pesticide applications. Am. J. Pub. Health 80, 689-693.
20. G 111ette, J. H., and Mitchell, J. L. A. (1991). Ornithine decarboxylase: a biochemical marker of repair in damaged tissue. Life Sci. 48, 1501-1510.
21. Hagino, N., and Lee, J. W. (1985). Effect of maternal nicotine on the development of sites for [3H]nicotine binding in the fetal brain. Int. J. Dev. Neurosci. 3, 567-571.
22. Hohmann, C. F., Brooks, A. R., and Coyle, J. T. (1988). Neonatal lesions of the basal forebrain cholinergic neurons result in abnormal cortical development. Dev. Brain Res. 42, 253-264.
23. Kaplan, J. G., Kessler, J., Rosenberg, N., and Pack, D. (1993). Sensory disturbances associated with Dursban (chlorpyrifos) exposure. Neurology 43, 2193-2196.
24. Lichtensteiger, W., Ribary, U., Schlumpf, M., Odermatt, B., and Widmer, H. R. (1988). Prenatal adverse effects of nicotine on the developing brain. Prog. Brain Res. 73, 137-157.
25. Lidow, M. S., and Rakic, P. (1994). Unique profiles of the a 1-, cr2-, and B-adrenergic receptors in the developing cortical plate and transient embryonic zones of the rhesus monkey. J. Neurosci. 14, 4064-4078.
26. McFarland, B. J., Seidler, F. J., and Slotkin, T. A. (1991). Inhibition of DNA synthesis in neonatal rat brain regions caused by acute nicotine administration. Dev. Brain Res. 58, 223-229.
27. Navarro, H. A., Seidler, F. J., Eylers, J. P., Baker, F. E., Dobbins, S. S., Lappi, S. E., and Slotkin, T. A. (1989). Effects of prenatal nicotine exposure on development of central and peripheral cholinergic neuro transmitter systems. Evidence for cholinergic trophic influences in developing brain. J. Pharmacol. Exp. Ther. 251, 894-900.
28. Nolan, R. J., Rick, D. L., Freshour, N. L., and Saunders, J. H. (1984). Chlorpyrifos: Pharmacokinetics in human volunteers. Toxicol. Appl. Pharmacol. 73, 8-15.
29. Pavlik, A., and Jelinek, R. (1979). Effect of cycloheximide administered to rats in early postnatal life: Correlation of brain changes with behaviour in adulthood. Brain Res. 167, 200-205.
30. Pavlik, A., and Teisinger, J. (1980). Effect of cycloheximide administered to rats in early postnatal life: Prolonged inhibition of DNA synthesis in the developing brain. Brain Res. 192, 531-541.
31. Pope, C. N., and Chakraborti, T. K. (1992). Dose-related inhibition of brain and plasma cholinesterase in neonatal and adult rats following sublethal organophosphate exposures. Toxicology 73, 35-43.
32. Pope, C. N., Chakraborti, T. K., Chapman, M. L., and Farrar, J. D. (1992). Long-term neurochemical and behavioral effects induced by acute chlorpyrifos treatment. Pharmacol. Biochem. Behav. 42, 251-256.
33. Pope, C. N., Chakraborti, T. K., Chapman, M. L., Farrar, J. D., and Arthun, D. (1991). Comparison of in vivo cholinesterase inhibition in neonatal and adult rats by three organophosphorothioate insecticides. Toxicology 68, 51-61.
34. Reinis, S., and Goldman, J. M. (1980). The Development of the Brain: Biological and Functional Perspectives. Charles C. Thomas, Springfield, 1L.
35. Richardson, R. J., Moore, T. B., Kayyali, U. S., and Randall, J. C. (1993). Chlorpyrifos: Assessment of potential for delayed neurotoxicity by repeated dosing in adult hens with monitoring of brain acetylcholinesterase, brain and lymphocyte neurotoxic esterase and plasma butyrylcholinester-ase activities. Fund. Appl. Toxicol. 21, 89-96.
36. Rodier, P. M. (1988). Structural-functional relationships in experimentally induced brain damage. Prog. Brain Res. 73, 335-348.
37. Schanberg, S. M., Evoniuk, G., and Kuhn, C. M. (1984). Tactile and nutritional aspects of maternal care: Specific regulators of neuroendocrine function and cellular development. Proc. Soc. Exp. Biol. Med. 175, 135-146.
38. Shelton, D. L., Nadler, J. V., and Cotman, C. W. (1979). Development of high affinity choline uptake and associated acetylcholine synthesis in the rat fascia dentata. Brain Res. 163, 263-275.
39. Slotkin, T. A. (1992). Prenatal exposure to nicotine: What can we leant from animal models? In Maternal Substance Abuse and the Developing Nervous System (I. S. Zagon and T. A. Slotkin, Eds.), pp. 97-124. Academic Press, San Diego.
40. Slotkin, T. A., and Bartolomé, J. (1983). Ornithine decarboxylase: Marker of neuroendocrine and neurotransmitter actions. Meth. Enzymol. 103, 590-603.
41. Slotkin, T. A., and Bartolomé, J. (1986). Role of ornithine decarboxylase and the polyamines in nervous system development: A review. Brain Res. Bull. 17, 307-320.
42. Slotkin, T. A., Cowdery, T. S., Orband, L., Pachman, S., and Whitmore, W. L. (1986). Effects of neonatal hypoxia on brain development in the rat: Immediate and long-term biochemical alterations in discrete regions. Brain Res. 374, 63-74.
43. Slotkin, T. A., Levant, B., Orband-M 111er, L., Queen, K. L., and Stasheff, S. (1988). Do sympathetic neurons coordinate cellular development in the heart and kidney? Effects of neonatal central and peripheral catechol-aminergic lesions on cardiac and renal nucleic acids and proteins. J. Pharmacol. Exp. Ther. 244, 166-172.
44. Slotkin, T. A., Orband-M 111er, L., and Queen, K. L. (1987a). Development of [’HJnicotine binding sites in brain regions of rats exposed to nicotine prenatally via maternal injections or infusions. J. Pharmacol. Exp. Ther. 242, 232-237.
45. Slotkin, T. A., Orband-M 111er, L., Queen, K. L., Whitmore, W. L., and Seidler, F. J. (1987b). Effects of prenatal nicotine exposure on biochemical development of rat brain regions: Maternal drug infusions via osmotic minipumps. J. Pharmacol. Exp. Ther. 240, 602-611.
46. Slotkin, T. A., Persons, D., Slepetis, R. J., Taylor, D., and Bartolomé, J. (1984). Control of nucleic acid and protein synthesis in developing brain, kidney, and heart of the neonatal rat: Effects of a-difluoromethylomith-ine. a specific, irreversible inhibitor of ornithine decarboxylase. Teratology 30, 211-224.
47. Slotkin, T. A., Whitmore, W. L., Orband-M 111er, L., Queen K. L., and Haim, K. (1987c). Beta adrenergic control of macromolecule synthesis in neonatal rat heart, kidney and lung: Relationship to sympathetic neuronal development. J. Pharmacol. Exp. Ther. 243, 101-109.
48. Snedecor, G. W., and Cochran, W. G. (1967). Statistical Methods. Iowa State Univ. Press, Ames, Iowa.
49. Taha, T. E., and Gray, R. H. (1993). Agricultural pesticide exposure and perinatal mortality in central Sudan. Bull. WHO 71, 317-321.
50. Willis W. O., De Peyster, A., Molgaard, C. A., Walker, C., and MacKen-drick, T. (1993). Pregnancy outcome among women exposed to pesticides through work or residence in an agricultural area. J. Occun. Med. 35, 943-949.
51. Zahalka E., Seidler, F. J., Lappi, S. E., Yanai, J., and Slotkin T. A. (1993). Differential development of cholinergic nerve terminal markers in rat hrain regions: Implications for nerve terminal density, impulse activity and specific gene expression. Brain Res. 601, 221-229.
52. Zahalka, E. A., Seidler, F. J., Lappi, S. E., McCook, E. C., Yanai, J., and Slotkin, T. A. (1992). Deficits in development of central cholinergic pathways caused by fetal nicotine exposure: Differential effects on choline acetyltransferase activity and ’Hhemicholinium-3 binding. Nettro-toxicol. Teratol. 14, 375-382.