erbB-2 Oncogene Inhibition by Geldanamycin Derivatives: Synthesis, Mechanism of Action, and Structure-Activity Relationships

Journal of Medicinal Chemistry

Volumn 38, Issue 19, 1995, Pages 3813-3820

  Schnur, R C ^a   Corman, M L ^a   Gallaschun, R J ^a   Cooper, B A ^a   Dee, M F ^a   Doty, J L ^a   Muzzi, M L ^a   DiOrio, C I ^a   Barbacci, E G ^a   Miller, P E ^a   Pollack, V A ^a   Savage, D M ^a   Sloan, D E ^a   Pustilnik, L R ^a   Moyer, J D ^a   Moyer, M P ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,5 DIHYDROGELDANAMYCIN; ANSAMYCIN DERIVATIVE; ANTINEOPLASTIC ANTIBIOTIC; GELDANAMYCIN; GELDANAMYCIN DERIVATIVE; HERBIMYCIN A; ONCOPROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; GENE REPRESSION; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE; RAT; STRUCTURE ACTIVITY RELATION;

ANIMAL; ANTIBIOTICS; ANTIBIOTICS, ANTINEOPLASTIC; BREAST NEOPLASMS; FEMALE; GENES, ERBB-2; HUMAN; MICE; MICE, NUDE; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PROTEIN-TYROSINE KINASE; QUINONES; RATS; RECEPTOR, ERBB-2; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0029123128     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00019a011     Document Type: Article

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