Functional Analysis and DNA Polymorphism of the Tandemly Repeated Sequences in the 5′-Terminal Regulatory Region of the Human Gene for Thymidylate Synthase

Cell Structure and Function

Volumn 20, Issue 3, 1995, Pages 191-197

  Horie, Nobuyuki ^a   Takeishi, Keiichi ^a   Aiba, Hideo ^b   Oguro, Katsuhiko ^b   Hojo, Hiroatsu ^b  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b SHIZUOKA CHILDREN'S HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

THYMIDYLATE SYNTHASE;

ARTICLE; DELETION MUTANT; DNA POLYMORPHISM; GENE CONTROL; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TANDEM REPEAT;

BASE SEQUENCE; DNA; HELA CELLS; HUMAN; MOLECULAR SEQUENCE DATA; POLYMORPHISM (GENETICS); REPETITIVE SEQUENCES, NUCLEIC ACID; SUPPORT, NON-U.S. GOV'T; THYMIDYLATE SYNTHASE;

EID: 0029122937     PISSN: 03867196     EISSN: 13473700     Source Type: Journal    
DOI: 10.1247/csf.20.191     Document Type: Article

References (25)

1. Maley, F. and Maley, G. F. 1960. Nucleotide Interconversions : II. Elevation of deoxycytidylate deaminase and thymidylate synthase in regenerating rat liver. J. Biol. Chem., 235 : 2968-2970.
2. Haurani, F. I., Kardinal, C. G., and Biermann, W. A. 1978. Thymidylate synthase and dihydrofolic acid reductase in the stimulated human lymphocyte. J. Cell Physiol., 95 : 49-56.
3. Hartmann, K.-U. and Heidelberger, C. 1961. Studies on fluorinated pyrimidines : XIII. Inhibition of thymidylate synthetase. J. Biol. Chem., 236 : 3006-3013.
4. Ayusawa, D., Shimizu, K., Koyama, H., Kaneda, S., Takeishi, K., and Seno, T. 1986. Cell-cycle-directed regulation of thymidylate synthase messenger RNA in human diploid fibroblasts stimulated to proliferate. J. Mol. Biol., 190 : 559-567.
5. Keyomaris, K. and Pardee, A. B. 1992. Differential expression of thymidylate synthase message versus protein in synchronized human MCF-7 breast cancer cells. Proc. Am. Assoc. Cancer Res., 32 : 330.
6. Takeishi, K., Ayusawa, D., Kaneda, S., Shimizu, K., and SENO, T. 1984. Molecular cloning of genomic DNA segments partially coding for human thymidylate synthase from the mouse cell transformant. J. Biochem., 95 : 1477-1483.
7. Takeishi, K., Kaneda, S., Ayusawa, D., Shimizu, K., Gotoh, O., and Seno, T. 1989. Human thymidylate synthase gene : Isolation of phage clones which cover a functionally active gene and structural analysis of the region upstream from the translation initiation codon. J. Biochem., 106 : 575-583.
8. Ayusawa, D., Takeishi, K., Kaneda, S., Shimizu, K., Koyama, H., and Seno, T. 1984. Isolation of functional cDNA clones for human thymidylate synthase. J. Biol. Chem., 259 : 14361-14364.
9. Takeishi, K., Kaneda, S., Ayusawa, D., Shimizu, K., Gotoh, O., and Seno, T. 1985. Nucleotide sequence of a functional cDNA for human thymidylate synthase. Nucleic Acids Res., 13 : 2035-2043.
10. Kaneda, S., Nalbantoglu, J., Takeishi, K., Shimizu, K., Gotoh, O., Seno, T., and Ayusawa, D, 1990. Structural and functional analysis of the human thymidylate synthase gene. J. Biol. Chem., 265 : 20277-20284.
11. Horie, N., Chimoto, M., Nozawa, R., and Takeishi, K. 1993. Characterization of regulatory sequences and nuclear factors that function in cooperation with the promoter of the human thymidylate synthase gene. Biochim. Biophys. Acta, 1216 : 409-416.
12. Koyama, H. and Kodama, H. 1982. Adenine phosphoribosyltransferase deficiency in cultured mouse mammary tumor FM3A cells resistant to 4-carbamoylimidazolium 5-olate. Cancer Res., 42 : 4210-4214.
13. Sambrook, J., Fritsch, E. F., and Maniatis, T. 1989. Molecular Cloning : A Laboratory Manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
14. Herrmann, B. G. and Frishauf, A.-M. 1987. Isolation of genomic DNA. In Guide to Molecular Cloning Techniques, Methods in Enzymology (Berger, S. L. and Kimmel, A. R. eds.), Academic Press, New York, Vol. 152, pp. 180–183.
15. Sanger, F., Nicklen, S., and Coulson, A. F. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA, 74 : 5463-5467.
16. Horie, N., Nozawa, R., and Takeishi, K. 1992. Identification of cellular differentiation-dependent nuclear factors that bind to a human gene for thymidylate synthase. Biochem. Biophys. Res. Commun., 185 : 127-133.
17. Nevins, J. R. 1992. E2F : A link between the Rb tumor suppresser protein and viral oncoproteins. Science, 258 : 424-429.
18. Deng, T., Li, D., Jenh, C.-H., and Johnson, L. F. 1986. Structure of the gene for mouse thymidylate synthase : Locations of introns and multiple transcriptional start sites. J. Biol. Chem., 261 : 16000-16005.
19. Geng, Y. and Johnson, L. F. 1993. Lack of an initiator element is responsible for multiple transcriptional initiation sites of the TATA-less mouse thymidylate synthase promoter. Mol. Cell. Biol., 13 : 4894-4903.
20. Chu, E., Koeller, D. M., Casey, J. L., Drake, J. C., Chabner, B. A., Elwood, P. C., Zinn, S., and Allegra, C. J. 1991. Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase. Proc. Natl. Acad. Sci. USA, 88 : 8977-8981.
21. Chu, E., Voeller, D., Koeller, D. M., Drake, J. C., Takimoto, C. H., Maley, G. F., Male, F., and Allegra, C. J. 1993. Identification of an RNA binding site for human thymidylate synthase. Proc. Natl. Acad. Sci. USA, 90 : 517-521.
22. Takeishi, K., Watanabe, Y., Isono, K., and Horie, N. 1993. Cloning and structural analysis of a human thymidylate synthase pseudogene split by several Alu sequences. Nucleic Acids Symposium Series No. 29, p. 141, IRL Press, Oxford.
23. Hori, T., Takahashi, E., Ayusawa, D., Takeishi, K., Kaneda, S., and Seno, T. 1990. Regional assignment of the human thymidylate synthase (TS) gene to chromosome band 18p11.32 by nonisotopic in situ hybridization. Hum. Genet., 85 : 576-580.
24. Verkerk, A. J. M. H., Pieretti, M., Sutcliffe, J. S., Fu, Ying-Hui, Kuhl, D. P. A., Pizzuti, A., Reiner, O., Richards, S., Victoria, M. F., Zhang, F., Eussen, B. E., Van Ommen, G. B., Blonden, L. A. J., Riggins, G. J., Chastain, J. L., Kunst, C. B., Gljaard, H., Caskey, C. T., Nelson, D. L., Oostra, B. A., and Warren, S. T. 1991. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell, 65 : 905-914.
25. The Huntington's Disease Collaborative Research Group. 1993. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell, 72 : 971-983.