Targeting of transforming growth factor-alpha expression to pituitary lactotrophs in transgenic mice results in selective lactotroph proliferation and adenomas

Endocrinology

Volumn 136, Issue 10, 1995, Pages 4479-4488

  Mc andrew, Joanne ^a,b   Paterson, Andrew J ^a,b   Asa, Sylvia L ^a,b   Mc carthy, Kevin J ^a,b   Kudlow, Jeffrey E ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL GROWTH; GENE EXPRESSION; GROWTH INHIBITION; HORMONAL REGULATION; HORMONE SYNTHESIS; HUMAN; HYPOPHYSIS ADENOMA; MOUSE; PRIORITY JOURNAL; PROLACTIN SYNTHESIS; PROLACTINOMA; PROMOTER REGION; PROTEIN TARGETING; TRANSGENIC MOUSE;

ANIMAL; BASE SEQUENCE; BLOTTING, SOUTHERN; CELL DIVISION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; MALE; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PITUITARY GLAND, ANTERIOR; PITUITARY NEOPLASMS; POLYMERASE CHAIN REACTION; PROLACTIN; PROLACTINOMA; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 0029122724     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/endo.136.10.7664668     Document Type: Article

References (60)

1. de Larco JE, Todaro GJ 1978 Growth factors from murine sarcoma virus-transformed cells. Proc Natl Acad Sci USA 75:4001-4005
2. Derynck R, Goeddel DV, Ullrich A, Gutterman JU, Williams RD, Bringman TS, Berger WH 1987 Synthesis of messenger RNAs for transforming growth factors α and β and the epidermal growth factor receptor by human tumors. Cancer Res 47:707-712
3. Nister N, Libermann TA, Betsholtz C, Pettersson M, Claesson-Welsh L, Heldin C-H, Schlessinger J, Westermark B 1988 Expression of mRNAs for platelet-derived growth factor and transforming growth factor-« and their receptors in human malignant glioma cell lines. Cancer Res 48:3910-3918
4. Wilcox JN, Derynck R 1988 Developmental expression of transforming growth factors alpha and beta in mouse fetus. Mol Cell Biol 8:3415-3422
5. Kobrin MS, Asa SL, Samsoondar J, Kudlow JE 1987 «-Transforming growth factor in bovine anterior pituitary gland: secretion by dispersed cells and immunohistochemical localization. Endocrinology 121:1412-1416
6. Wilcox JN, Derynck R 1988 Localization of cells synthesizing transforming growth factor alpha mRNA in mouse brain. J Neurosci 8:1901-1904
7. Kudlow JE, Leung AW, Kobrin MS, Paterson AJ, Asa SL 1989 Transforming growth factor-a mRNA in the mammalian brain. Immunohistochemical detection in neurons and characterization of its mRNA. J Biol Chem 264:3880-3883
8. Coffey Jr RJ, Derynck R, Wilcox JN, Bringman TS, Goustin AS, Moses HL, Pittelkow MR 1987 Production and auto-induction of transforming growth factor-a in human keratinocytes. Nature 328: 817-820
9. Cartlidge SA, Elder JB 1989 Transforming growth factor a and epidermal growth factor levels in normal human gastrointestinal mucosa. Br J Cancer 60:657-660
10. Snedecker SM, Brown CF, DiAugustine RP 1991 Expression and functional properties of transforming growth factor a and epidermal growth factor during mouse mammary gland ductal morphogenesis. Proc Natl Acad Sci USA 88:276-280
11. Madtes DK, Raines EW, Sakariassen KS, Assoian RK, Spom MB, Bell GI, Ross R 1988 Induction of transforming growth factor-a in activated human alveolar macrophages. Cell 53:285-293
12. Rappolee DA, Mark D, Banda MJ, Werb Z 1988 Wound macrophages express TGFa and other growth factors in vivo: analysis by mRNA phenotyping. Science 241:708-712
13. Carpenter G, Stoscheck CM, Preston YA, DeLarco JE 1983 Antibodies to the epidermal growth factor receptor block the biological activities of sarcoma growth factor. Proc Natl Acad Sci USA 80: 5627-5630
14. Massague J 1983 Epidermal growth factor-like transforming growth factor II. Interaction with the epidermal growth factor receptors in the human placenta membranes and A431 cells. J Biol Chem 258: 13614-13620
15. Samsoondar J, Kobrin MS, Kudlow J E 1986 a-Transforming growth factor secreted by untransformed bovine anterior pituitary cells in culture. I. Purification from conditioned medium. J Biol Chem 216:14408-14413
16. Chabot J-G, Walker P, Pelletier G 1986 Distribution of epidermal growth factor binding sites in the adult rat anterior pituitary gland. Peptides 7:45-50
17. Asa SL, Penz G, Kovacs K, Ezrin C 1982 Prolactin cells in the human pituitary. A quantitative immunocytochemical analysis. Arch Pathol Lab Med 106:360-369
18. Lu LK, Meites J 1971 Inhibition by L-dopa and monoamine oxidase inhibitors of pituitary prolactin release; stimulation by methyldopa and d-amphetamine. Proc Soc Exp Biol Med 137:480-483
19. MacLeod RM, Fontham EH, Lehmeyer JE 1970 Prolactin and growth hormone production as influenced by catecholamines and agents that affect brain catecholamines. Neuroendocrinology 6:283-294
20. Franks S 1983 Regulation of prolactin secretion by estrogens: physiological and pathological significance. Clin Sci 64:457-462
21. Borgundvaag B, Kudlow JE, Mueller SG, George SR 1992 Dopamine receptor activation inhibits estrogen stimulated transforming growth factor-a gene expression and growth in anterior pituitary, but not in uterus. Endocrinology 130:3453-3458
22. Bates SE, Davidson NE, Valverius EM, Fréter CE, Dickson RB, Tan JP, Kudlow JE, Lippman ME, Salomon DS 1988 Expression of transforming growth factor-a and its messenger ribonucleic acid in human breast cancer: its regulation by estrogen and its possible functional significance. Mol Endocrinol 2:543-555
23. Mueller SG, Kobrin MS, Paterson AJ, Kudlow JE 1989 Transforming growth factor-a expression in the anterior pituitary gland: regulation by epidermal growth factor and phorbol ester in dispersed cells. Mol Endocrinol 3:967-983
24. Murdoch GH, Potter E, Nicloaisen AK, Evans RM, Rosenfeld MG 1982 Epidermal growth factor rapidly stimulates prolactin gene transcription. Nature 300:192-193
25. Schonbrunn A, Krasnoff M, Westendorf JM, Tashjian AH 1980 Epidermal growth factor and thyrotropin-releasing hormone act similarly on a clonal cell strain: modulation of hormone production and inhibition of cell proliferation. J Cell Biol 85:786-797
26. Driman DK, Kobrin MS, Kudlow JE, Asa SL 1992 Transforming growth factor-alpha in normal and neoplastic human endocrine tissues. Hum Pathol 23:1360-1365
27. Ezzat S, Walpola IA, Ramyar L, Smyth HS, Asa SL 1995 Membrane-anchored expression of transforming growth factor-alpha in human pituitary adenoma cells. J Clin Endocrinol Metab 80: 534-539
28. Crenshaw III EB, Kalla K, Simmons DM, Swanson LW, Rosenfeld MG 1989 Cell-specific expression of the prolactin gene in transgenic mice is controlled by synergistic interactions between promoter and enhancer elements. Genes Dev 3:959-972
29. Borrelli E, Sawchenko PE, Evans RM 1993 Pituitary hyperplasia induced by ectopic expression of nerve growth factor. Proc Natl Acad Sci USA 89:2764-2768
30. Chomczynski P, Sacci N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
31. McCarthy KJ, Couchman JR 1990 Basement membrane chondroitin sulfate proteoglycans: Localization in adult rat tissues. J Histochem Cytochem 38:1479-1486
32. Derynck R, Robert AB, Winkler ME, Chen EY, Goeddel DV 1984 Human transforming growth factor-a: precursor structure and expression in £. coli. Cell 38:287-297
33. Yamamoto N, Seo H, Suganuma N, Matsui N, Nakane T, Kuwayama A, Kagoyama N 1986 Effect of estrogen on prolactin mRNA in the rat pituitary. Analysis by in situ hybridization and immunohistochemisty. Neuroendocrinology 42:494-497
34. Saeki T, Cristiano A, Lynch MJ, Brattain M, Kim N, Normanno N, Kenny N, Ciardiello F, Salomon DS 1991 Regulation by estrogen through the 5'-flanking region of the transforming growth factor-a gene. Mol Endocrinol 5:1955-1963
35. Finley EL, Ramsdell JS 1994 A transforming growth factor-alpha pathway is expressed in GH4Q rat pituitary tumors and appears necessary for tumor formation. Endocrinology 135:416-422
36. Mueller SG, Paterson AJ, Kudlow JE 1990 Transforming growth factor a in arterioles: cell surface processing of its precursor by elastases. Mol Cell Biol 10:4596-4602
37. Pandiella A, Massagué J 1991 Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process. Proc Natl Acad Sci USA 88:1726-1730
38. Pandiella A, Massagué J 1991 Multiple signals activate cleavage of the membrane transforming growth factor-alpha precursor. J Biol Chem 266:5769-5773
39. Bosenberg MW, Pandiella A, Massagué J 1992 The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGF alpha into soluble growth factor. Cell 71:1157-1165
40. Finley EL, King JS, Ramsdell JS 1994 Human pituitary somatotropes express transforming growth factor-alpha and its receptor. J Endocrinol 141:547-554
41. Wong ST, Winchell LF, McCune BK, Earp HS, Teixidô J, Massagué J, Herman B, Lee DC 1989 The TGFa precursor expressed on the cell surface binds to the EGF receptor on adjacent cells leading to signal transduction. Cell 56:495-506
42. Brachmann R, Lindquist PB, Nagashima M, Kohr W, Lipari T, Napier M, Derynck R 1989 Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors. Cell 56:691-700
43. Kasselberg AG, Orth DN, Gray ME, Stahlman MT 1985 Immu-nocytochemical localization of human epidermal growth factor/ urogastrone in several human tissues. J Histochem Cytochem 33: 315-322
44. Mann GB, Fowler KJ, Gabriel A, Nice EC, Williams RL, Dunn AR 1993 Mice with a null mutation of the TGFa gene have abnormal skin architecture, wavy hair and curly whiskers and often develop corneal inflammation. Cell 73:249-261
45. Luetteke NC, Qui TH, Peiffer RL, Oliver P, Smithies O, Lee DC 1993 TGFa deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell 73:263-278
46. Pascall JC, Brown KD 1988 Structural analysis of the 5'-flanking sequence of the mouse epidermal growth factor gene. Mol Endocrinol 1:5-11
47. Burrow GN, Wortzman G, Rewcastle NB, Holgate RC, Kovacs K 1981 Microadenomas of the pituitary and abnormal sellar tomograms in an unselected autopsy series. N Engl J Med 304:156-158
48. Matsui Y, Halter SA, Holt T, Hogan BLM, Coffey RJ 1990 Development of mammarv hyperplasia and neoplasia in MMTV-TGFa transgenic mice. Cell 61:1147-1155
49. Jhappan C, Stahle C, Harkins RN, Fausto N, Smith GH, Merlino GT 1990 TGFa overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell 61:1137-1146
50. Sandgren EP, Luetteke NC, Palmiter RD, Brinster RL, Lee DC 1990 Overexpression of TGFa in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia and carcinoma of the breast. Cell 61:1121-1135
51. Lee G-H, Merlino G, Fausto N 1992 Development of liver tumors in transforming growth a transgenic mice. Cancer Res 5162-5170
52. Vassar R, Hutton ME, Fuchs E 1992 Transgenic overexpression of transforming growth factor a bypasses the need for c-Ha-ras mutations in mouse skin tumorigensis. Mol Cell Biol 12:4643-4653
53. Jhappan C, Takayama H, Dickson RB, Merlino G 1994 Transgenic mice provide genetic evidence that transforming growth factor alpha promotes skin tumorigenesis via I I-ras-dependent and H-ras-independent pathways. Cell Growth Differ 5:385-394
54. Bjorge JD, Paterson AJ, Kudlow JE 1989 Phorbol ester or epidermal growth factor (EGF) concurrently stimulated the accumulation of the mRNA for the EGF receptor and its ligand transforming growth factor-a in a breast cancer cell line. J Biol Chem 264:4021-4027
55. Kudlow JE, Cheung C-YM, Bjorge JD 1986 Epidermal growth factor stimulates the synthesis of its own receptor in a human breast cancer cell line. J Biol Chem 261:4134-4138
56. Mueller SG, Kudlow JE 1991 Transforming growth factor-j3 (TGF/3) inhibits TGFa expression in bovine anterior pituitary-derived cells. Mol Endocrinol 5:1439-1446
57. Gicquel C, Le Bouc Y, Luton JP, Girard F, Bertagna X 1992 Mono-clonality of corticotroph macroadenomas in Cushings disease. J Clin Endocrinol Metab 75:472-475
58. Alexander JM, Biller BM, Bikkal H, Zervas NT, Arnold A, Klibanski A 1990 Clinically nonfunctioning pituitary tumors are monoclonal in origin. J Clin Invest 86:336-340
59. Herman V, Drazin NZ, Gonsky R, Melmed S 1993 Molecular screening of pituitary adenomas for gene mutations and rearrangements. J Clin Endocrinol Metab 77:50-55
60. Gonsky R, Herman V, Melmed S, Fagin J 1991 Transforming DNA sequences present in human prolactin-secreting pituitary tumors. Mol Endocrinol 5:1687-1695