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Volumn 17, Issue 5, 1995, Pages 454-459

Blood distribution and single–dose pharmacokinetics of leflunomide

Author keywords

A77 1726; Blood distribution; Hwa 486; Leflunomide; Leflunomide metabolite; Pharmacokinetics

Indexed keywords

LEFLUNOMIDE; TERIFLUNOMIDE;

EID: 0029122535     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/00007691-199510000-00004     Document Type: Article
Times cited : (48)

References (24)
  • 1
    • 0025980747 scopus 로고
    • Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of auto immune disorders and reactions leading to transplantation rejection
    • Bartlett RR, Dimitrijevic M, Mattar T, et al. Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of auto immune disorders and reactions leading to transplantation rejection. Agents Actions 1991;32:10.
    • (1991) Agents Actions , vol.32 , pp. 10
    • Bartlett, R.R.1    Dimitrijevic, M.2    Mattar, T.3
  • 2
    • 0027732959 scopus 로고
    • New small molecule immunosuppressants for transplantation: Review of essential concepts
    • Morris RE. New small molecule immunosuppressants for transplantation: review of essential concepts. J Heart Lung Transplant 1993;12:275.
    • (1993) J Heart Lung Transplant , vol.12 , pp. 275
    • Morris, R.E.1
  • 3
    • 0027279125 scopus 로고
    • Leflunomide, a novel immunosuppressive agent: The mechanism of inhibition of T cell proliferation
    • Chong AS-F, Finnegan A, XingLi J, et al. Leflunomide, a novel immunosuppressive agent: The mechanism of inhibition of T cell proliferation. Transplantation 1993;55:1361.
    • (1993) Transplantation , vol.55 , pp. 1361
    • Chong, A.-F.1    Finnegan, A.2    Xingli, J.3
  • 4
    • 0027501428 scopus 로고
    • Inhibition of the epidermal growth factor receptor tyrosine kinase activity by Leflunomide
    • Mattar T, Kulvinder K, Bartlett RR, et al. Inhibition of the epidermal growth factor receptor tyrosine kinase activity by Leflunomide. FEBS Lett 1993;334:161.
    • (1993) FEBS Lett , vol.334 , pp. 161
    • Mattar, T.1    Kulvinder, K.2    Bartlett, R.R.3
  • 5
    • 0027536435 scopus 로고
    • Prolongation of allogeneic transplanted skin grafts and induction of tolerance by Leflunomide, a new immunosuppressive isoaxol derivative
    • Schorlemmer HU, Seiler FR, Bartlett RR. Prolongation of allogeneic transplanted skin grafts and induction of tolerance by Leflunomide, a new immunosuppressive isoaxol derivative. Transplant Proc 1993;25:763.
    • (1993) Transplant Proc , vol.25 , pp. 763
    • Schorlemmer, H.U.1    Seiler, F.R.2    Bartlett, R.R.3
  • 6
    • 0026060988 scopus 로고
    • Prevention of kidney and skin graft rejection in rats by Leflunomide, a new immunomodulatory agent
    • Küchle CCA, Thoenes GH, Langer KH, et al. Prevention of kidney and skin graft rejection in rats by Leflunomide, a new immunomodulatory agent. Transplant Proc 1991,23:1083.
    • (1991) Transplant Proc , vol.23 , pp. 1083
    • Küchle, C.C.A.1    Thoenes, G.H.2    Langer, K.H.3
  • 7
    • 0028354267 scopus 로고
    • Leflunomide in experimental transplantation: Control of rejection and alloanti-body production, reversal of acute rejection and interaction with cyclosporine
    • Williams JW, Xiao F, Foster P, et al. Leflunomide in experimental transplantation: Control of rejection and alloanti-body production, reversal of acute rejection and interaction with cyclosporine. Transplantation 1994;57:1223.
    • (1994) Transplantation , vol.57 , pp. 1223
    • Williams, J.W.1    Xiao, F.2    Foster, P.3
  • 8
    • 0027970997 scopus 로고
    • Leflunomide controls rejection in hamster to rat cardiac xenografts
    • Xiao F, Chong AS, Foster P, et al. Leflunomide controls rejection in hamster to rat cardiac xenografts. Transplantation 1994;58:828.
    • (1994) Transplantation , vol.58 , pp. 828
    • Xiao, F.1    Chong, A.S.2    Foster, P.3
  • 9
    • 0028235690 scopus 로고
    • An evaluation of Leflunomide in the canine renal transplantation model
    • McChensney LP, Xiao F, Sankary HN, et al. An evaluation of Leflunomide in the canine renal transplantation model. Transplantation 1994;57:1717.
    • (1994) Transplantation , vol.57 , pp. 1717
    • Mc Chensney, L.P.1    Xiao, F.2    Sankary, H.N.3
  • 10
    • 0028317333 scopus 로고
    • Newer immunosuppressive drugs in concordant xenografting-transplantation of hamster heart to rat
    • Kemp E, Dieperink H, Jensen J, et al. Newer immunosuppressive drugs in concordant xenografting-transplantation of hamster heart to rat. Xenotransplantation 1994; 1:102.
    • (1994) Xenotransplantation , vol.1 , pp. 102
    • Kemp, E.1    Dieperink, H.2    Jensen, J.3
  • 11
    • 0026721038 scopus 로고
    • Suppression of natural xenophile antibodies with the novel immunomodulating drug Leflunomide
    • Ulrichs K, Kaitschick J, Bartlett RR, et al. Suppression of natural xenophile antibodies with the novel immunomodulating drug Leflunomide. Transplant Proc 1992;24:718.
    • (1992) Transplant Proc , vol.24 , pp. 718
    • Ulrichs, K.1    Kaitschick, J.2    Bartlett, R.R.3
  • 12
    • 0028853980 scopus 로고
    • Measurement of the active leflunomide metabolite (A77 1726) by reverse-phase high-performance liquid chromatography
    • Dias VC, Lucien J, LeGatt DF, Yatscoff RW. Measurement of the active leflunomide metabolite (A77 1726) by reverse-phase high-performance liquid chromatography. Ther Drug Monit 1995;17:84–8.
    • (1995) Ther Drug Monit , vol.17 , pp. 84-88
    • Dias, V.C.1    Lucien, J.2    Legatt, D.F.3    Yatscoff, R.W.4
  • 13
    • 0027450730 scopus 로고
    • Distribution of cyclosporin G (Nva2 cyclosporin) in blood and plasma
    • Yatscoff RW, Honcharik N, Lukowski M, et al. Distribution of cyclosporin G (Nva2 cyclosporin) in blood and plasma. Clin Chem 1993;39:213.
    • (1993) Clin Chem , vol.39 , pp. 213
    • Yatscoff, R.W.1    Honcharik, N.2    Lukowski, M.3
  • 15
    • 0345259714 scopus 로고
    • Yatscoff RW. Blood distribution of mycophenolic acid
    • Langman LL, LeGatt DF, Yatscoff RW. Blood distribution of mycophenolic acid. Clin Biochem 1994;27:206.
    • (1994) Clin Biochem , vol.27 , pp. 206
    • Langman, L.L.1    Legatt, D.F.2
  • 16
    • 0023251121 scopus 로고
    • Cyclosporine: Measurement of fraction unbound in plasma
    • Legg B, Rowland M., Cyclosporine: Measurement of fraction unbound in plasma. J Pharm Pharmacol 1987;39:599.
    • (1987) J Pharm Pharmacol , vol.39 , pp. 599
    • Legg, B.1    Rowland, M.2
  • 17
    • 0016850021 scopus 로고
    • Separation of plasma lipoproteins by density-gradient ultracentrifugation
    • Redgrave TG, Roberts DCK, West CE. Separation of plasma lipoproteins by density-gradient ultracentrifugation. Anal Biochem 1975;65:42.
    • (1975) Anal Biochem , vol.65 , pp. 42
    • Redgrave, T.G.1    Roberts, D.2    West, C.E.3
  • 20
    • 0019919022 scopus 로고
    • Role of lipoproteins and erythrocytes in the
    • Lemaire M, Tillement JP. Role of lipoproteins and erythrocytes in the in vitro binding and distribution of cyclosporine A in the blood. J Pharm Pharmacol 1982;34:715.
    • (1982) J Pharm Pharmacol , vol.34 , pp. 715
    • Lemaire, M.1    Tillement, J.P.2
  • 21
    • 85039333513 scopus 로고
    • Distribution and protein binding of FK506 a potent immunosuppressive mac-rolide lactone, in human blood and its uptake by erythrocytes
    • Nagase K, Iwasaki K, Nozaki K, et al. Distribution and protein binding of FK506 a potent immunosuppressive mac-rolide lactone, in human blood and its uptake by erythrocytes. J Pharm Pharmacol 1982;34:715.
    • (1982) J Pharm Pharmacol , vol.34 , pp. 715
    • Nagase, K.1    Iwasaki, K.2    Nozaki, K.3
  • 22
    • 0026438717 scopus 로고
    • Pharmacokinetics of rapamycin: Single-dose studies in the rabbit
    • Honcharik N, Fryer J, Yatscoff RW. Pharmacokinetics of rapamycin: single-dose studies in the rabbit. Ther Drug Monit 1992;14:475.
    • (1992) Ther Drug Monit , vol.14 , pp. 475
    • Honcharik, N.1    Fryer, J.2    Yatscoff, R.W.3
  • 23
    • 0027371669 scopus 로고
    • Single dose pharmacokinetics of the new immunosuppressant RS-61443 in the rabbit
    • Yatscoff RW, Keenan R, LeGatt DF. Single dose pharmacokinetics of the new immunosuppressant RS-61443 in the rabbit. Ther Drug Monit 1993;15:400.
    • (1993) Ther Drug Monit , vol.15 , pp. 400
    • Yatscoff, R.W.1    Keenan, R.2    Legatt, D.F.3
  • 24
    • 0021991646 scopus 로고
    • The pharmacokinetics of cyclosporin: I. Single dose and constant rate infusion studies in the rabbit
    • Awni WM, Sawchuck RJ. The pharmacokinetics of cyclosporin: I. Single dose and constant rate infusion studies in the rabbit. Drug Metab Dispos 1985; 13:127.
    • (1985) Drug , vol.13 , pp. 127
    • Awni, W.M.1    Sawchuck, R.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.