Signalling by hedgehog family proteins in Drosophila and vertebrate development

Current Opinion in Genetics and Development

Volumn 5, Issue 4, 1995, Pages 492-498

  Ingham, Philip W ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE;

CARBOXY TERMINAL SEQUENCE; DROSOPHILA; EMBRYO; EMBRYO CELL; EMBRYO DEVELOPMENT; GENE EXPRESSION; IMAGINAL DISC; LIMB DEVELOPMENT; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; REVIEW; SIGNAL TRANSDUCTION; VERTEBRATE;

ANIMAL; DROSOPHILA; EMBRYO AND FETAL DEVELOPMENT; EMBRYONIC INDUCTION; LIMB BUD; PROTEINS; SIGNAL TRANSDUCTION; VERTEBRATES;

EID: 0029121566     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-437X(95)90054-K     Document Type: Article

References (67)

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2. Sonic hedgehog, a member of a family of putative signaling molecules is implicated in the regulation of CNS and limb polarity
3. Products, genetic linkage and limb patterning activity of a murine hedgehog gene
4. Sonic hedgehog mediates the polarizing activity of the ZPA
5. A functionally conserved homolog of the Drosophila segment polarity gene hedgehog is expressed in tissues with polarising activity in zebrafish embryos
6. Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
7. Restrictions to floor plate induction by hedgehog and winged-helix genes in the neural tube of frog embryos.
8. Activin induces the expression of the Xenopus homolog of sonic hedgehog during mesoderm formation in Xenopus explants
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13. Requirements for hedgehog, a segment polarity gene, in patterning larval and adult cuticle of Drosophila
14. Molecular organisation and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning in Drosophila
15. Secretion and localised transcription suggests a role in positional signalling for products of the segmentation gene hedgehog
16. The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation
17. Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication
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21. Midline signals that control the dorso-ventral polarity of the neural tube
22. Control of dorsoventral patterning of somitic derivatives by notochord and floor plate.
23. Induction of floor plate differentiation by contact dependent, homeogenetic signals
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28. Proteolytic processing yields two secreted forms of Sonic hedgehog
29. The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
30. Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo
31. Floor plate and motor neuron induction by different concentrations of the amino terminal cleavage product of Sonic hedgehog autoproteolysis
32. Requirement of 19 kDalton form of Sonic hedgehog for induction of distinct ventral cell types in vertebrate CNS explants
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34. Secretion of the amino-terminal fragment of the Hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila
35. Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein
36. Targeted expression of the signalling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings
37. Cell-interaction between compartments establishes the proximal-distal axis of Drosophila legs
38. Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing
39. Induction of a mirror-image duplication of anterior wing structures by localized hedgehog expression in the anterior compartment of Drosophila melanogaster wing imaginal discs
40. Hedgehog is a signalling protein with a key role in patterning Drosophila imaginal discs
41. Organising activity of wingless protein in Drosophila
42. Dual functions of wingless in the Drosophila leg imaginal disc
43. The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina
44. The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye
45. Growth and differentiation in the Drosophila eye coordinated by hedgehog
46. Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures
47. Interaction between the signaling molecules wnt7a and shh during vertebrate limb development — dorsal signals regulate anteroposterior patterning
48. Sonic hedgehog and Fgf-4 act through a signalling cascade and feedback loop to integrate growth and patterning of the developing limb bud
49. A positive feedback loop coordinates growth and patterning in the vertebrate limb
50. Dorsalizing signal wnt-7a required for normal polarity of d-v and a-p axes of mouse limb
51. Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb
52. The Drosophila patched gene encodes a putative membrane protein required for segmental patterning
53. The Drosophila segment polarity gene patched encodes a protein with multiple potential membrane spanning domains
54. The Drosophila segment polarity gene patched is involved in a position-signalling mechanism in imaginal discs
55. The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development
56. Role of the Drosophila patched gene in positional signalling
57. Genetic analysis of hedgehog signalling in the Drosophila embryo
58. Distinct pathways for autocrine and paracrine Wingless signalling in Drosophila embryos
59. Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a suppressor of fused background reveals interaction with costal-2
60. Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila
61. Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster
62. A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila
63. Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning
64. cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs
65. Protein kinase A and hedgehog signaling in Drosophila limb development
66. Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development
67. Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A