CD28 and CTLA-4 have opposing effects on the response of T ceils to stimulation

Journal of Experimental Medicine

Volumn 182, Issue 2, 1995, Pages 459-465

  Krummel, Matthew F ^a   Allison, James P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIGEN PRESENTATION; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CELL STIMULATION; CROSS LINKING; ENZYME IMMOBILIZATION; HAMSTER; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANIMAL; ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; ANTIGENS, CD3; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; LYMPHOCYTE ACTIVATION; LYMPHOKINES; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; SIGNAL TRANSDUCTION; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0029120245     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.182.2.459     Document Type: Article

References (50)

1. June, C.H., J.A. Bluestone, L.M. Nadler, and C.B. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today 15: 321-331.
2. Jenkins, M.K. 1994. The ups and downs of costimulation. Immunity. 1: 443-446.
3. Linsley, P.S., and J.A. Ledbetter. 1993. The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11: 191-212.
4. Harding, F., J.G. McArthur, J.A. Gross, D.H. Raulet, and J.P. Allison. 1994. CD28 mediated signalling costimulates murine T cells and prevents the induction of anergy in T cell clones. Nature (Lottd.). 356: 607-609.
5. Holsti, M.A., J. McArthur, J.P. Allison, and D.H. Raulet. 1994. Role of IL-6, IL-1, and CD28 signaling in responses of mouse CD4+ T cells to immobilized anti-TCR monoclonal antibody. J. Immunol. 152: 1618-1624.
6. Caux, C., B. Vanvervliet, C. Massacrier, M. Azuma, K. Okumura, L.L. Lanier, and J. Banchereau. 1994. B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. J. Exp Med. 180: 1841-1847.
7. Linsley, P.S., E.A. Clark, and J.A. Ledbetter. 1990. The T cell antigen, CD28, mediates adhesion with B cells by interacting with the activation antigen, B7/BB-1. Proc. Natl. Acad. Set. USA. 87: 5031-5035.
8. Azuma, M., D. Ito, H. Yagita, K. Okumura, J.H. Phillips, L. Lanier, and C. Somoza. 1993. B70 antigen is a second ligand for CTLA-4 and CD28. Nature (Lond.). 366: 76-79.
9. Razi-Wolf, Z., G.J. Freeman, F. Galvin, B. Benacerraf, L. Nadler, and H. Reiser. 1992. Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells. Proc. Natl. Acad. Sci. USA. 89: 4210-4214.
10. Reiser, H., G.J. Freeman, Z. Razi-Wolf, C.D. Gimmi, B. Benacerraf, and N.M. Nadler. 1992. Murine B7 antigen provides a costimulatory signal for activation of murine T lymphocytes via the T cell receptor/CD3 complex. Proc. Natl. Acad. Sci. USA. 89: 271-275.
11. Linsley, P.S., W. Brady, L. Grosmaire, A. Aruffo, N.K. Damle, and J.A. Ledbetter. 1991. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp Med. 173: 721-730.
12. Gimmi, C.D., G.J. Freeman, J.G. Gribben, K. Sugita, A.S. Freedman, C. Morimoto, and L.M. Nadler. 1991. B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secret interleukin 2. Proc. Natl. Acad. Sci. USA. 88: 6575-6579.
13. Reiser, H., G.J. Freeman, Z. Razi-Wolf, C.D. Gimmi, B. Benacerraf, and L.M. Nadler. 1992. Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex. Proc. Natl. Acad. Sci. USA. 89: 271-275.
14. Murphy, E.E., G. Terres, S.E. Macatonia, C.S. Hsieh, J. Mattson, L.L. Lanier, M. Wysocka, G. Trinchieri, K. Murphy, and A. O’Garra. 1994. B7 and interleukin-12 cooperate for proliferation and IFN-g production by mouse Thl clones that are unresponsive to B7 costimulation. J. Exp Med. In press.
15. Inaba, K., M. Witmer-Pack, M. Inaba, K.S Hathcock, H. Sakuta, M. Azuma, H. Yagita, K. Okumura, P.S. Linsley, S. Ikehara, et al. 1994. The tissue distribution of the B7-2 costimulator in mice: Abundant expression on dendritic cells in situ and during maturation in vitro. J. Exp Med. 180: 1849-1860.
16. Linsley, P.S., W. Brady, M. Umes, L.S. Grosmaire, N.K. Damle, and J.A. Ledbetter. 1991. CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp Med. 174: 561-569.
17. Freeman, G.J., F. Borriello, R.J. Hodes, H. Reiser, K.S. Hathcock, G. Laszlo, A.J. McKnight, J. Kim, L. Ku, D.B. Lombard, et al. 1993. Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science (Wash. DC). 262: 907-909.
18. Lenschow, D.J., G.H.-T. Su, L.A. Zuckerman, N. Nabavi, C.L. Jellis, G.S. Gray, J. Miller, and J.A. Bluestone. 1993. Expression and functional significance of an additional ligand for CTLA-4. Proc. Natl. Acad. Sci. USA. 90: 11054-11058.
19. Linsley, P.S., P.M. Wallace, J. Johnson, M.G. Gibson, J.L. Greene, J.A. Ledbetter, C. Singh, and M.A, Tepper. 1992. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science (Wish. DC). 257: 792-795.
20. Lenschow, D.J., Y. Zeng, J.R. Thistlewaite, A. Montag, W. Brady, M.G. Gibson, P.S. Linsley, and J.A. Bluestone. 1992. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig. Science (Wash. DC). 257: 789-792.
21. Brunet, J.F., F. Denizot, M.F. Luciani, M. Roux-Dosseto, M. Suzan, M.F. Mattei, and P. Golstein. 1987. A new member of the immunoglobulin superfamily CTLA-4. Nature (Lond.). 328: 267-270.
22. Harper, K., C. Balzano, E. Rouvier, M.G. Mattei, M.F. Luciani, and P. Golstein. 1991. CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location. J. Immunol. 147: 1037-1044.
23. Lindsten, T., K.P. Lee, E.S. Harris, B. Petryniak, N. Craighead, P.J. Reynolds, D.B. Lombard, G.J. Freeman, L.M. Nadler, G.S. Gray, et al. 1993. Characterization of CTLA-4 structure and expression on human T cells. J. tmmunol. 151:3489-3499.
24. Linsley, P.S., J.L. Greene, P. Tan, J. Bradshaw, J.A. Ledbetter, C. Anasetti, and N.K. Damle. 1992. Coexpression and functional cooperativity of CTLA-4 and CD28 on activated T lymphocytes. J. Exp Med. 176: 1595-1604.
25. Damle, N.K., K. Klussman, G. Leytze, S. Myrdal, A. Aruffo, J.A. Ledbetter, and P.S. Linsley. 1994. Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7. J. Immunol. 152: 2686-2697.
26. Walunas, T.L., D.J. Lenschow, C.Y. Bakker, P.S. Linsley, G.J. Freeman, J.M. Green, C.B. Thompson, and J.A. Bluestone. 1994. CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1: 405-413.
27. Lane, P., W. Gerhard, S. Hubele, A. Lanzavecchia, and F. McConnell. 1993. Expression and functional properties of mouse BB1/B7 using a fusion protein between mouse CTLA-4 and human gl. Immunology. 80: 56-61.
28. McKearn, T.J., F.W. Fitch, D.E. Smilek, M. Sarmiento, and F.P. Stuart. 1979. Properties of rat anti-MHC antibodies produced by cloned rat-mouse hybridomas. Immunol. Rev. 47: 91-98.
29. Jitsukawa, T., S. Nakajima, I. Sugawara, and H. Watanabe. 1989. Increased coating efficiency of antigens and preservation of original antigenic structures after coating in ELISA. J. Immunol. Methods. 116: 251-256.
30. Allison, J.P., W.L. Havran, M. Poenie, J. Kimura, L. Degraffenreid, S. Ajami, G. Duwe, A. Weiss, and R. Tsien. 1987. Expression and function of CD3 on murine thymocytes. In The T Cell Receptor, UCLA Symposia on Molecular and Cellular Biology, New Series. J. Kappler, and M. Davis, editors. Alan R. Liss, Inc., New York. pp. 33-45.
31. Gross, J.A., E. Callas, and J.P. Allison. 1992. Identification and distribution of the costimulatory receptor CD28 in the mouse. J. Immunol. 149: 380-388.
32. Havran, W.L., S.C. Grell, G. Duwe, J. Kimura, A. Wilson, A.M. Kruisbeek, R.L. O’Brien, W. Born, R.E. Tigelaar, and J.P. Allison. 1989. Limited diversity of TCR g chain expression of murine Thy-1+ dendritic epidermal cells revealed by Vg3-specific monoclonal antibody. Proc. Natl. Acad. Sci. USA. 86: 4185-4189.
33. Ozato, K., and D.H. Sachs. 1981. Monoclonal antibodies to mouse MHC antigens. J. Immunol. 126: 317-323.
34. Symington, F., and J. Sprent. 1981. A monoclonal antibody detecting an la specificity mapping in the I-A or I-E subregion. Immunogenetics. 14: 53-61.
35. Mishell, B., and S. Shiigi. 1980. Selected Methods in Cellular Immunology. W.H. Freeman Co., San Francisco, pp. 23-24.
36. Mescher, M.F. 1992. Surface contact requirements for activation of cytotoxic T lymphocytes. Immunol 149: 2402-2405.
37. Green, J.M., P.J. Noel, A.I. Sperling, T.L. Walunas, G.S. Gray, J.A. Bluestone, and C.B. Thompson. 1994. Absence of B7-dependent responses in CD28-deficient mice. Immunity. 1: 501-508.
38. Lu, Y., A. Granelli-Piperno, J.M. Bjorndahl, C.A. Phillips, and J.M. Trevillyan. 1992. CD28-induced T cell activation. Evidence for a protein-tyrosine kinase signal transduction pathway. J. Immunol. 149: 24-29.
39. August, A., S. Gibson, Y. Kawakami, G.B. Mills, and B. Dupont. 1994. CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line. Proc. Natl. Acad. Sci. USA. 91: 9347-9351.
40. Ward, S.G., J. Westwick, N.D. Hall, andD.M. Sansom. 1993. Ligation of CD28 receptor by B7 induces formation of D-3 phosphotides in T lymphocytes independently of T cell receptor activation. Eur. J. Immunol. 23: 2572-2577.
41. Songyang, Z., S.E. Shoelson, J. McGlade, P. Olivier, T. Pawson, X.R. Bustelo, M. Barbacid, H. Sabe, H. Hanafusa, T. Yi, et al. 1994. Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, Vav. Mol. Cell. Biol. 14: 2777-2785.
42. Songyang, Z., S.E. Shoelson, M. Chaudhuri, G. Gish, T. Pawson, W.G. Haser, F. King, T. Roberts, S. Ratnofsky, R.J. Lechleider, et al. 1993. SH2 domains recognize specific phos-phopeptide sequences. Cell. 72:767-778.
43. August, A., and B. Dupont. 1993. CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase. Int. Immunol. 6: 769-774.
44. Prasad, K.V., Y.C. Cai, M. Raab, B. Duckworth, L. Cantley, S.E. Shoelson, and C.E. Rudd. 1994. T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. Proc Natl. Acad. Sci. USA. 91: 2834-2838.
45. Truitt, K.E., C.M. Hicks, and J.B. Imboden. 1994. Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3'-kinase in Jurkat T cells. J. Exp. Med. 179: 1071-1076.
46. Stein, P.H., J.D. Fraser, and A. Weiss. 1994. The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase. Mol. Cell. Biol. 14: 3392-3402.
47. Pages, F., M. Ragueneau, R. Rottapel, A. Truneh, J. Nunes, J. Imbert, and D. Olive. 1994. Binding of phophatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling. Nature (hand.). 369: 327-329.
48. Schneider, H., V.S. Prasad, S.E. Shoelson, and C.E. Rudd. 1995. CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells. J. Exp. Med. 181: 351-355.
49. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell. 77: 727-736.
50. Lindsten, T., C.H. June, J.A. Ledbetter, G. Stella, and C.B. Thompson. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science (Wash. DC). 244: 339-343.