Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds

Pharmacology and Therapeutics

Volumn 67, Issue 2, 1995, Pages 247-281

  Safe, Stephen H ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Ah receptor; antiestrogenicity; gene expression

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ALDEHYDE DEHYDROGENASE; ANTIESTROGEN; AROMATIC HYDROCARBON RECEPTOR; CATHEPSIN D; CYTOCHROME P450 ISOENZYME; DIBENZOFURAN DERIVATIVE; ESTRADIOL; GLUTATHIONE TRANSFERASE; OXIDOREDUCTASE; POLYCHLORINATED DIBENZODIOXIN; POLYCHLORINATED DIBENZOFURAN;

ANIMAL CELL; BREAST CANCER; CANCER CELL; ENDOCRINE SYSTEM; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW;

ALDEHYDE DEHYDROGENASE; ANIMAL; BASE SEQUENCE; BREAST NEOPLASMS; CATHEPSIN D; CYTOCHROME P-450 ENZYME SYSTEM; ESTRADIOL; ESTROGEN ANTAGONISTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE TRANSFERASE; HUMAN; MAMMARY NEOPLASMS; MICE; MOLECULAR SEQUENCE DATA; RATS; RECEPTORS, ARYL HYDROCARBON; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TETRACHLORODIBENZODIOXIN; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0029118684     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/0163-7258(95)00017-B     Document Type: Review

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189. scc
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191. Cutaneous histologic findings in chemical workers with and without chloracne with past exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
192. 13C-nuclear magnetic resonance studies
193. Studies of the mechanisms of toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
194. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse
195. Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin
196. Increase of CYP1A1 mRNA and AHH activity by inhibitors of either protein or RNA synthesis in mouse hepatocytes in primary culture
197. Regulation of mouse CYP1A1 gene expression by dioxin: requirement of two cis-acting elements during induction
198. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the epidermal growth factor receptor in hepatic plasma membranes of rainbow trout
199. Regulatory gene product of the Ah locus: characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation
200. The Ah receptor: mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds
201. Phorbol esters inhibit the dioxin receptor-mediated transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes by 2,3,7,8-tetrachlorodibenzo-p-dioxin
202. Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene
203. Effect of thyroidectomy and thyroxine on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunotoxicity
204. Accumulation of the nuclear dioxin (Ah) receptor and transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes
205. Association of the Ah receptor with the 90-kDa heat shock protein
206. Chemical cross-linking of the cytosolic and nuclear forms of the Ah receptor in hepatoma cell line 1c1c7
207. Developmental and reproductive toxicity of dioxins and related compounds: cross-species comparisons
208. Dioxin receptor and C/EBP regulate the function of the glutathione S-transferase Ya gene xenobiotic response element
209. Radioligand-dependent differences in the molecular properties of the mouse and rat hepatic aryl hydrocarbon receptor complexes
210. TCDD reduces serum melatonin levels in Long-Evans rats
211. Chlorinated dibenzo-p-dioxins: potent inducer of δ-aminolevulinic acid synthetase and aryl hydrocarbon hydroxylase. II. A study of the structure-activity relationship
212. Genetic expression of aryl hydrocarbon hydroxylase by 2,3,7,8-tetrachlorodibenzo-p-dioxin: evidence for a receptor mutation in genetically nonresponsive mice
213. Variation in the molecular mass of the Ah receptor among vertebrate species and strains of rats
214. b−3 alleles
215. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons. Examinations of the mechanism of toxicity
216. Genetic expression of aryl hydrocarbon hydroxylase activity. Induction of monooxygenase activities and cytochrome, P-450 formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice generally ‘nonresponsive’ to other aromatic hydrocrbons
217. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol: evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase
218. Studies on the mechanism of action of the chlorinated dibenzo-p-dioxins and related compounds
219. The murine Ah locus: a new allele and mapping to chromosome 12
220. The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy
221. Dual roles of the 90 kDa heat shock protein Hsp 90 in modulating functional activities of the dioxin receptor
222. Characterization of a novel cytochrome P450 from the transformable cell line, C3H/10T1/2
223. Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells
224. Hypothyroxinemia and hypothermia in rats in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin administration
225. Thyroid Status and thermogenesis in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin
226. Role of the aryl hydrocarbon receptor nuclear translocation protein in aryl hydrocarbon (dioxin) receptor action
227. Physicochemical characterization of the nuclear form of Ah receptor from mouse hepatoma cells exposed in culture to 2,3,7,8-tetrachlorodibenzo-p-dioxin
228. Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1
229. The human cytochrome CYP1A2 gene contains regulatory elements responsive to 3-methylcholanthrene
230. The human CYP1A2 gene and induction by 3-methylcholanthrene: a region of DNA that supports Ah-receptor binding and promoter-specific induction
231. Dietary exposure and human levels of PCDDs and PCDFs
232. Sources of exposure, environmental concentrations and exposure assessment of PCDDs and PCDFs
233. Environmental concentrations and ecotoxicological effects of PCDDs, PCDFs and related compounds
234. Molecular organization of the human cathepsin D gene
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237. Down-regulation of nuclear aryl hydrocarbon receptor DNA-binding and transactivation functions: requirement for a labile or inducible factor
238. Phorbol ester-mediated suppression of cytochrome P450 Cyp1a-1 induction in murine skin: involvement of protein kinase C
239. Suppression of cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells by 12-O-tetradecanoylphorbol-13-acetate and inhibitors of protein kinase C
240. Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT)
241. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor
242. 2,3,7,8-Tetrachlorodibenzo-p-dixin versus 3-methylcholanthrene: comparative studies of Ah receptor binding, transformation, and induction of CYP1A1
243. Endometriosis in Rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
244. Polychlorinated biphenyls in the global ecosystem
245. Aryl hydrocarbon-induced interactions at multiple DNA elements of diverse sequence — a multicomponent mechanism for activation of cytochrome P4501A1 (CYP1A1) gene transcription
246. Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan
247. Comparative activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and progesterone on antiestrogens in the female rat uterus
248. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats
249. Kinetics of the association of several tritiated polychlorinated dibenzo-p-dioxin and dibenzofuran congeners with hepatic cytosolic Ah receptor from the Wistar rat
250. Effect of thyroidectomy and thyroxine in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced toxicity
251. Effect of thyroid hormones on liver microsomal enzyme induction in rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
252. Glutathione S-transferases, structure, regulation, and therapeutic implications
253. Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inductible expression by planar aromatic compounds
254. Decreased ligand binding to the hepatic glucocorticoid and epidermal growth factor receptors after 2,3,4,7,8-pentachlorodibenzofuran and 1,2,3,4,7,8-hexachlorodibenzofuran treatment of pregnant mice
255. 2+ requirement
256. Post-transcriptional destabilization of estrogen receptor messenger RNA in MCF-7 cells by 12-0-tetradecanoylphorbol-13-acetate
257. Cytochrome P4501A1 is rapidly induced in normal human keratinocytes in the absence of xenobiotics
258. Suspension-mediated induction of Hepa 1c1c7 Cyp1a-1 expression is dependent on the Ah receptor signal transduction pathway
259. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans
260. PCBs and human health
261. The aryl hydrocarbon (Ah) receptor
262. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs)
263. MCDF, 6-methyl-1,3,8-trichlorodibenzofuran
264. Development and validation of in vitro induction assays for toxic halogenated mixtures
265. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antiestrogens: characterization and mechanism of action
266. Mechanism of action of TCDD as an antiestrogen in transformed human breast cancer and rodent cell lines
267. Dual regulation of cytochrome P450EF expression via the aryl hydrocarbon receptor and protein stabilization in C3H/10T1/2 cells
268. Mouse cytochrome P-450EF, representative of a new IB subfamily of cytochrome P450s
269. Protein kinase C is not involved in Ah receptor transformation and DNA binding
270. Molecular characterization of the murine Ahr gene: organization, promoter analysis, and chromosomal assignment
271. Abnormal oxidative metabolism of estradiol in women with breast cancer
272. TCDD-mediated changes in hepatic epidermal growth factor receptor may be a critical event in the hepatocarcinogenic action of TCDD
273. The human dioxin-inducible NAD(P)H:quinone oxidoreductase cDNA-encoded protein expressed in COS-1 cells is identical to diaphorase 4
274. Protein-DNA interactions at a dioxin-responsive enhancer-mutational analysis of the DNA-binding site for the liganded Ah receptor
275. Identification of a cytochrome P450 gene by reverse transcription-PCR using degenerate primers containing inosine
276. cDNA cloning, sequence analysis, and induction by aryl hydrocarbons of a murine cytochrome P450 gene, Cyp1b1
277. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on serum concentrations and the uterotrophic actions of exogenous estrone in rats
278. Expression of cytochromes P-450c and P-450d mRNAs in cultured rat hepatocytes. 3-Methylcholanthrene induction is regulated primarily at the posttranscriptional level
279. Effect of staurosporine on the Ah receptor levels in Hepa 1 cells
280. Location of regulatory elements responsible for drug induction in the rat cytochrome P-450c gene
281. 2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an extensive alteration of 17β-estradiol metabolism in human breast cancer cells
282. 17β-Estradiol hydroxylation catalyzed by human cytochrome P4501A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA
283. Stimulation of 17β-estradiol metabolism in MCF-7 cells by bromochloro- and chloromethyl-substituted dibenzo-p-dioxins and dibenzofurans: correlations with antiestrogenic activity
284. Rat CYP1A1 negative regulatory element: biological activity and interaction with a protein from liver and hepatoma cells
285. Protective effect of dietary brussels sprouts against mammary carcinogenesis in Sprague-Dawley rats
286. Induction of ethoxyresorufin-O-deethylase and inhibition of glucocorticoid receptor binding in skin and liver of haired and hairless HRS/J mice by topically applied 2,3,7,8-tetrachlorodibenzo-p-dioxin
287. Decreased human birth weights after in utero exposure to PCBs and PCDFs are associated with decreased placental EGF-stimulated receptor autophosphorylation capacity
288. Characterization of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decreases in dexamethasone binding to rat hepatic cytosolic glucocorticoid receptor
289. Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1β
290. Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2
291. The Ah-receptor: genetics, structure and function
292. 125I]-iodo-7,8-dibromodibenzo-p-dioxin in cell culture
293. Superinduction of 2,3,7,8-tetrachlorodibenzo-para-dioxin-inducible expression of aldehyde dehydrogenase by the inhibition of protein synthesis
294. Structure of the 5′ flanking region of class 3 aldehyde dehydrogenase in the rat
295. Environmental chloracne update and overview
296. Transient superinducibility of cytochrome P450c (CYP1A1) mRNA and transcription
297. Intake of 2,3,7,8 chlorine substituted dioxins, furans and planar PCBs from food in The Netherlands: median and distribution
298. Differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible CYP1A1 expression in human breast carcinoma cell lines involve altered transacting factors
299. Restoration of Ah responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor
300. elective responsiveness of breast cancer cells to indole-3-carbinol, a chemopreventative agent
301. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated depression of rat testicular heme synthesis and microsomal cytochrome P450
302. The Ah locus: correlation of intranuclear appearance of inducerreceptor complex with induction of cytochrome P-450 mRNA
303. Physiological implications of estrogen receptor modulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin
304. Effects of TCDD-estradiol interactions in three strains of mice
305. Alteration of the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) by estradiol and tamoxifen
306. Induction of cytochrome P4501A1 in rat colon and liver by indole-3-carbinol and 5,6-benzoflavone
307. Relation between cytochrome P4501A1 expression and estrogen receptor content of human breast cancer cells
308. 1 inhibits TCDD-induced cytochrome P4501A1 expression in human lung cancer A549 cells
309. In situ and in vitro photoaffinity labeling of the nuclear aryl hydrocarbon (Ah) receptor from transformed rodent and human cell lines
310. Characterization of the aryl hydrocarbon receptor in the human C-4II cervical squamous carcinoma cell line
311. A comparison of the mouse versus human aryl hydrocarbon (Ah) receptor complex: effects of proteolysis
312. Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells
313. Dioxin-dependent and Ah receptor-dependent protein binding to xenobiotic responsive elements and G-rich DNA studied by in vivo footprinting
314. Mechanism of action of a repressor of dioxindependent induction of Cyp1a1 gene transcription
315. Inhibition of chemical carcinogenesis
316. The human estrogen receptor structural gene contains a DNA sequence that binds activated mouse and human Ah receptors: a possible mechanism of estrogen receptor regulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin
317. Ligand-dependent recruitment of the arnt coregulator determines DNA recognition by the dioxin receptor
318. Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation
319. The regulation of cytochrome P-450 gene expression
320. The regulation of gene expression of 2,3,7,8-tetrachlorodibenzo-p-dioxin
321. Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action
322. Mechanistic aspects of dioxin action
323. Mechanism of dioxin action: Ah receptormediated increase in promoter accessibility in vivo
324. Mechanism of dioxin action: receptor-enhancer interactions in intact cells
325. Delineation of sites mediating estrogen regulation of the rat creatine kinase B gene
326. c gene
327. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced porphyria in genetically inbred mice: partial antagonism and mechanistic studies
328. DNA sequence determinants for binding of transformed Ah-receptor to a dioxin-responsive enhancer
329. Induction of cytochrome P-450-dependent monooxygenase activities in rat hepatoma H-4IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: mechanistic studies using radiolabeled congeners
330. Evidence for a possible mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant Hepa 1c1c7 cells
331. 6-Methyl-138-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines evidence for the role of the Ah receptor
332. Antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17β-estradiol-induced pS2 expression