Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

Trends in Biochemical Sciences

Volumn 20, Issue 8, 1995, Pages 303-307

  Ui, Michio ^a   Okada, Taro ^b   Hazeki, Kaoru ^a   Hazeki, Osamu ^b  

^a Physical/Chemical Research Institute   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROTEIN TYROSINE KINASE; WORTMANNIN;

ENZYME INHIBITION; PRIORITY JOURNAL; REVIEW; SIGNAL PROCESSING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; MOLECULAR PROBES; PHOSPHATIDYLINOSITOLS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SIGNAL TRANSDUCTION;

EID: 0029118603     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(00)89056-8     Document Type: Review

References (49)

1. Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate
2. The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf.