The cellular response to neuregulins is governed by complex interactions of the erbB receptor family

Molecular and Cellular Biology

Volumn 15, Issue 10, 1995, Pages 5770-5776

  Riese II, David J ^a   Van Raaij, Tom M ^a   Plowman, Gregory D ^b,d   Andrews, Glenn C ^c   Stern, David F ^a  

^a YALE UNIVERSITY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^d SUGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL SURVIVAL; HUMAN; LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROLYMPHOCYTE; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION;

ANIMALIA;

EID: 0029118223     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.15.10.5770     Document Type: Article

References (55)

1. Barbacci, E. G., B. C. Guarino, J. G. Stroh, D. H. Singleton, K. J. Rosnack, J. D. Moyer, and G. C. Andrews. 1995. The structural basis for the specificity of EGF and heregulin binding. J. Biol. Chem. 270:9585-9589.
2. Carraway, K. L., III, M. X. Sliwkowski, R. Akita, J. V. Platko, P. M. Guy, A. Nuijens, A. J. Diamonti, R. L. Vandlen, L. C. Cantley, and R. A. Cerione. 1994. The erbB3 gene product is a receptor for heregulin. J. Biol. Chem. 269:14303-14306.
3. Carraway, K. L., III, S. P. Soltoff, A. J. Diamonti, and L. C. Cantley. 1995. Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3. J. Biol. Chem. 270:7111-7116.
4. Collins, M. K. L., J. Downward, A. Miyajima, K. Maruyama, K.-I. Arai, and R. C. Mulligan. 1988. Transfer of functional EGF receptors to an IL3-dependent cell line. J. Cell. Physiol. 137:293-298.
5. Corfas, G., D. L. Falls, and G. D. Fischbach. 1993. ARIA, a protein that stimulates acetylcholine receptor synthesis, also induces tyrosine phosphorylation of a 185-kDa muscle transmembrane protein. Proc. Natl. Acad. Sci. USA 90:1624-1628.
6. Corfas, G., K. M. Rosen, H. Aratake, R. Krauss, and G. D. Fischbach. 1995. Differential expression of ARIA isoforms in the rat brain. Neuron 14:103-115.
7. erbB4 receptor. J. Biol. Chem. 268: 18407-18410.
8. bcr/abl protein. Proc. Natl. Acad. Sci. USA 85:9312-9316.
9. Danilenko, D. M., B. D. Ring, J. Z. Lu, J. E. Tarpley, D. Chang, M. Liu, D. Wen, and G. F. Pierce. 1995. Neu differentiation factor upregulates epidermal migration and integrin expression in excisional wounds. J. Clin. Invest. 95:842-851.
10. DiFiore, P. P., O. Segatto, W. G. Taylor, S. A. Aaronson, and J. H. Pierce. 1990. EGF receptor and erbB-2 tyrosine kinase domains confer cell specificity for mitogenic signaling. Science 248:79-83.
11. neu/erbB-2 in a subset of human breast tumors overexpressing this receptor. Cancer Res. 55:1946-1955.
12. Falls, D. L., K. M. Rosen, G. Corfas, W. S. Lane, and G. D. Fischbach. 1993. ARIA, a protein that stimulates acerylcholine receptor synthesis, is a member of the neu ligand family. Cell 72:801-815.
13. Fedi, P., J. H. Pierce, P. P. DiFiore, and M. H. Kraus. 1994. Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase Cγ or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members. Mol. Cell. Biol. 14:492-500.
14. Gill, G. N., T. Kawamoto, C. Cochet, A. Le, J. D. Sato, H. Masui, C. McLeod, and J. Mendelsohn. 1984. Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity. J. Biol. Chem. 259:7755-7760.
15. Goldman, R., R. Ben Levy, E. Peles, and Y. Yarden. 1990. Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation. Biochemistry 29:11024-11028.
16. erbB3 possesses an impaired tyrosine kinase activity. Proc. Natl. Acad. Sci. USA 91:8132-8136.
17. Harwerth, I. M., W. Wels, B. M. Marte, and N. E. Hynes. 1992. Monoclonal antibodies against the extracellular domain of the erbB-2 receptor function as partial ligand agonists. J. Biol. Chem. 267:15160-15167.
18. erbB2. Science 256:1205-1210.
19. Hynes, N. E., and D. F. Stern. 1994. The biology of erbB-2/neu/HER-2 and its role in cancer. Biochim. Biophys. Acta 1198:165-184.
20. Jo, S. A., X. Zhu, M. A. Marchionni, and S. J. Burden. 1995. Neuregulins are concentrated at nerve-muscle synapses and activate ACh-receptor gene expression. Nature (London) 373:158-161.
21. Kim, H.-H., S. L. Sierke, and J. G. Koland. 1994. Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product. J. Biol. Chem. 269:24747-24755.
22. King, C. R., I. Borrello, F. Bellot, P. Comoglio, and J. Schlessinger. 1988. EGF binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3. EMBO J. 7:1647-1651.
23. Kita, Y. A., J. Barff, Y. Luo, D. Wen, D. Brankow, S. Hu, N. Liu, S. A. Prigent, W. J. Gullick, and M. Nicolson. 1994. NDF/heregulin stimulates the phosphorylation of Her3/erbB3. FEBS Lett. 349:139-143.
24. Langton, B. C., M. C. Crenshaw, L. A. Chao, S. G. Stuart, R. W. Akita, and , J. E. Jackson. 1991. An antigen immunologically related to the external domain of gp185 is shed from nude mouse tumors overexpressing the c-erbB-2 (HER-2/neu) oncogene. Cancer Res. 51:2593-2598.
25. Li, J.-P., A. D. D'Andrea, H. F. Lodish, and D. Baltimore. 1990. Activation of cell growth by binding of Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor. Nature (London) 343:762-764.
26. Lu, H. S., D. Chang, J. S. Philo, K. Zhang, L. O. Narhi, N. Liu, M. Zhang, J. Sun, J. Wen, D. Yanagihara, D. Karunagaran, Y. Yarden, and B. Ratzkin. 1995. Studies on the structure and function of glycosylated and nonglycosylated neu differentiation factors. J. Biol. Chem. 270:4784-4791.
27. erbB2. Science 249:1552-1555.
28. Marchionni, M. A., A. D. J. Goodearl, M. S. Chen, O. Bermingham-McDonogh, C. Kirk, M. Hendricks, F. Danehy, D. Misumi, J. Sudhalter, K. Kobayashi, D. Wroblewski, C. Lynch, M. Baldassare, I. Hiles, J. B. Davis, J. J. Hsuan, N. F. Totty, M. Otsu, R. N. McBurney, M. D. Waterfield, P. Stroobant, and D. Gwynne. 1993. Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature (London) 362:312-318.
29. Marte, B. M., M. Jeschke, D. Graus-Porta, D. Taverna, P. Hofer, B. Groner, Y. Yarden, and N. E. Hynes. 1995. Neu differentiation factor/heregulin modulates growth and differentiation of HC11 mammary epithelial cells. Mol. Endocrinol. 9:14-23.
30. Meyer, D., and C. Birchmeier. 1994. Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development. Proc. Natl. Acad. Sci. USA 91:1064-1068.
31. Miller, A. D., and G. J. Rosman. 1989. Improved retroviral vectors for gene transfer and expression. BioTechniques 7:980-990.
32. Morrissey, T. K., A. D. O. Levi, A. Nuijens, M. X. Sliwkowski, and R. P. Bunge. 1995. Axon-induced mitogenesis of human Schwann cells involves heregulin and p185erbB2. Proc. Natl. Acad. Sci. USA 92:1431-1435.
33. Orr-Urtreger, A., L. Trakhtenbrot, R. Ben-Levy, D. Wen, G. Rechavi, P. Lonai, and Y. Yarden. 1993. Neuronal expression and chromosomal mapping of Neu differentiation factor to 8p12-p21. Proc. Natl. Acad. Sci. USA 90: 1867-1871.
34. Palacios, R., and M. Steinmetz. 1985. IL-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo. Cell 41:727-734.
35. Peles, E., S. S. Bacus, R. A. Koski, H. S. Lu, D. Wen, S. G. Ogden, R. Ben Levy, and Y. Yarden. 1992. Isolation of the Neu/HER-2 stimulatory ligand: a 44kd glycoprotein that induces differentiation of mammary tumor cells. Cell 69:205-216.
36. Peles, E., R. Ben-Levy, E. Tzahar, N. Lu, D. Wen, and Y. Yarden. 1993. Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships. EMBO J. 12:961-971.
37. Petti, L., L. A. Nilson, and D. DiMaio. 1991. Activation of the platelet-derived growth factor receptor by the bovine papillomavirus E5 transforming protein. EMBO J. 10:845-855.
38. erbB4, a fourth member of the epidermal growth factor receptor family. Proc. Natl. Acad. Sci. USA 90:1746-1750.
39. erbB4. Nature (London) 366:473-475.
40. Plowman, G. D., G. S. Whitney, M. G. Neubauer, J. M. Green, V. L. McDonald, G. J. Todaro, and M. Shoyab. 1990. Molecular cloning and expression of an additional epidermal growth factor receptor-related gene. Proc. Natl. Acad. Sci. USA 87:4905-4909.
41. Prigent, S. A., and W. J. Gullick. 1994 Identification of c-erbB-3 binding sites for phosphatidylinositol 3′-kinase and SHC using an EGF receptor/c-erbB-3 chimera. EMBO J. 13:2831-2841.
42. Riese, D. J., II, T. M. van Raaij, Y. Bermingham, G. D. Plowman, and D. F. Stern. Unpublished results.
43. Satoh, T., W. J. Fantl, J. A. Escobedo, L. T. Williams, and Y. Kaziro. 1993. Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types. Mol. Cell. Biol. 13:3706-3713.
44. Sefton, B., K. Beemon, and T. Hunter. 1979. Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo. J. Virol. 28:957-971.
45. Shah, N. M., M. A. Marchionni, I. Isaacs, P. Stroobant, and D. J. Anderson. 1994. Glial growth factor restricts mammalian neural crest stem cells to a glial fate. Cell 77:349-360.
46. Shawver, L. K., E. Mann, S. S. Elliger, T. C. Dugger, and C. L. Arteaga. 1994. Ligand-like effects induced by anti-c-erbB-2 antibodies do not correlate with and are not required for growth inhibition of human carcinoma cells. Cancer Res. 54:1367-1373.
47. Shibuya, H., M. Yoneyama, J. Ninomiya-Tsuji, K. Matsumoto, and T. Taniguchi. 1992. IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc. Cell 70:57-67.
48. Sliwkowski, M. X., G. Schaefer, R. W. Akita, J. A. Lofgren, V. D. Fitzpatrick, A. Nuijens, B. M. Fendly, R. A. Cerione, R. L. Vandlen, and K. L. Carraway III. 1994. Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin. J. Biol. Chem. 269:14661-14665.
49. Soltoff, S. P., K. L. Carraway III, S. A. Prigent, W. J. Gullick, and L. C. Cantley. 1994. ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor. Mol. Cell. Biol. 14:3550-3558.
50. neu: a potential model for receptor interactions. EMBO J. 7:995-1001.
51. Tzahar, E., G. Levkowitz, D. Karunagaran, L. Yi, E. Peles, S. Lavi, D. Chang, J. Liu, A. Yayon, D. Wen, and Y. Yarden. 1994. ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms. J. Biol. Chem. 269:25226-25233.
52. Velu, T. J., L. Beguinot, W. C. Vass, M. C. Willingham, G. T. Merlino, I. Pastan, and D. R. Lowy. 1987. Epidermal growth factor-dependent transformation by a human EGF receptor proto-oncogene. Science 238:1408-1410.
53. neu protein and EGF receptor molecules modulates EGF receptor function. Cell 61:1339-1347.
54. Wen, D., E. Peles, R. Cupples, S. V. Suggs, S. S. Bacus, Y. Luo, G. Trail, S. Hu, S. M. Silbiger, R. Ben Levy, R. A. Koski, H. S. Lu, and Y. Yarden. 1992. Neu differentiation factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit. Cell 69:559-572.
55. Wen, D., S. V. Suggs, D. Karunagaran, N. Liu, R. L. Cupples, Y. Luo, A. M. Janssen, N. Ben-Baruch, D. B. Trollinger, V. L. Jacobsen, S.-Y. Meng, H. S. Lu, S. Hu, D. Chang, W. Yang, D. Yanigahara, R. A. Koski, and Y. Yarden. 1994. Structural and functional aspects of the multiplicity of Neu differentiation factors. Mol. Cell. Biol. 14:1909-1919.