Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas - relationship to amplification and mRNA levels of CDK4 and CCND1

British Journal of Cancer

Volumn 72, Issue 2, 1995, Pages 393-398

  Maelandsmo, G ^a   Berner, J M ^a   Florenes V A ^a   Forus, A ^a   Hovig, E ^a   Fodstad, O ^a   Myklebost, O ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Chromosome 9p2l; Cyclin DI; Mtsi; Pl61Nk4; Prb

Indexed keywords

CYCLINE; ENZYME ACTIVATOR; ENZYME INHIBITOR; MESSENGER RNA; PROTEIN KINASE;

ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA TRANSCRIPTION; ENZYME REGULATION; GENE AMPLIFICATION; GENE DELETION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LIPOSARCOMA; MAJOR CLINICAL STUDY; MALIGNANT NEURILEMOMA; MOUSE; MUTATION RATE; NONHUMAN; OSTEOSARCOMA; PRIORITY JOURNAL; RHABDOMYOSARCOMA; SARCOMA; TUMOR SUPPRESSOR GENE;

ANIMAL; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CARRIER PROTEINS; CYCLIN D1; CYCLINS; DNA, NEOPLASM; ENZYME INHIBITORS; GENE AMPLIFICATION; GENE DELETION; GENE EXPRESSION; HOMOZYGOTE; HUMAN; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; ONCOGENE PROTEINS; PROTEIN P16; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER; SARCOMA; SUPPORT, NON-U.S. GOV'T; TRANSPLANTATION, HETEROLOGOUS;

EID: 0029118134     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.1995.344     Document Type: Article

References (31)

1. ANDREASSEN A, OYJORD T, HOVIG E, HOLM R, FLORENES VA, NESLAND JM, MYKLEBOST O, HOIE J, BRULAND OS, BORRESEN AL, AND FODSTAD O. (1993). p53 abnormalities in different subtypes of human sarcomas. Cancer Res., 53, 468-471.
2. BALDIN V, LUKAS J, MARCOTE M, PAGANO MJ, AND DRAETTA G. (1993). Cyclin D1 is a nuclear protein required for cell cycle progression in Gl. Genes Dev., 7, 812-821.
3. BARTKOVA J, LUKAS J, STRAUSS M, AND BARTER J. (1994). Cell cycle-related variation and tissue-restricted expression of human cyclin D1 protein. J. Pathol., 172, 237-245.
4. BATES S, PARRY D, BONETTA L, VOUSDEN K, DICKSON C, AND PETERS G. (1994). Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein. Oncogene, 9, 1633-1640.
5. BUCKLEY MF, SWEENEY KJ, HAMILTON JA, SINI RL, MANNING DL, NICHOLSON RI, DEFAZIO A, WATTS CKW, MUSGROVE EA, AND SUTHERLAND RL. (1993). Expression and amplification of cyclin genes in human breast cancer. Oncogene, 8, 2127-2133.
6. CAIRNS P, MAO L, MERLO A, LEE DJ, SCHWAB D, EBY Y, TORINO K, RIET PVD, BLAUGRUND JE, AND SIDRANSKY D. (1994). Rates of pl6 (MTS 1) mutations in primary tumors with 9p loss. Science, 265, 415-416.
7. CALDAS C, HAHN SA, DACOSTA LT, REDSTON MS, SCHUTTE M, SEYMOUR AB, WEINSTEIN CL, H RUB AN RH, YEO CJ, AND KERN SE. (1994). Frequent somatic mutations and homozygous deletions of the pl6 (MTSX) gene in pancreatic adenocarcinoma. Nature Genet. 8, 27-32.
8. CHURCH GM, AND GILBERT W. (1984). Genomic sequencing. Proc. Natl Acad. Sci. USA, 81, 1991-1995.
9. DEMETRICK DJ, ZHANG H, AND BEACH DH. (1994). Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes. Cytogenet. Cell Genet., 66, 72-74.
10. DOWDY SF, HINDS PW, LOUIE K, REED SI, ARNOLD A, AND WEINBERG RA. (1993). Physical interaction of the retinoblastoma protein with human D cyclins. Cell, 73, 499-511.
11. FEINBERG AP, AND VOGELSTEIN B. (1983). A technique for radio labeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem., 132, 6-13.
12. FORUS A, FLORENES V, MAELANDSMO GM, FODSTAD O, AND MYKLEBOST O. (1995). 12ql3-14 amplica in human sarcomas without MDM2 include CDK4, SAS and GADDX53/CHOP. Cytogenet. Cell Genet, (in press).
13. FORUS A, FLORENES VA, MAELANDSMO GM, MELTZER PS, FODSTAD O, AND MYKLEBOST O. (1993). Mapping of amplification units in the ql3–14 region of chromosome 12 in human sarcomas: Some amplica do not include MDM2. Cell Growth Different, 4, 1065-1070.
14. HAYASHI N, SUGIMOTO Y, TSUCHIYA E, OGAWA M, AND NAKAMURA Y. (1994). Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK41 (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomas. Biochem. Biophys. Res. Commun., 202, 1426-1430.
15. HINDS PW, MITTNACHT S, DULIC V, ARNOLD A, REED SI, AND WEINBERG RA. (1992). Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell, 70, 993-1006.
16. HUNTER T, AND PINES J. (1994). Cyclins and cancer. II. Cyclin D and CDK inhibitors come of age. Cell, 79, 573-582.
17. JIANG W, KAHN SM, TOMITA N, ZHANG YJ, LU SH, AND WEINSTEIN IB. (1992). Amplification and expression of human cyclin D gene in esophageal cancer. Cancer Res., 52, 2980-2983.
18. JIANG W, ZHANG YJ, KAHN SM, HOLLSTEIN MC, SANTELLA RM, LU SH, HARRIS CC, MONTESANO R, AND WEINSTEIN IB. (1993). Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc. Natl Acad. Sci. USA, 90, 9026-9030.
19. KAMB A, GRUIS NA, WEAVERFELDHAUS J, LIU Q, HARSHMAN K, TAVTIGIAN SV, STOCKERT E, DAY III RS, JOHNSON BE, AND SKOLNICK MH. (1994). A cell cycle regulator potentially involved in genesis of many tumor types. Science, 264, 436-440.
20. KHATIB ZA, MATSUSHIME H, VALENTINE M, SHAPIRO DN, SHERR CJ, AND LOOK AT. (1993). Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. Cancer Res., 53, 5535-5541.
21. LAMMIE GA, FANTL V, SMITH R, SCHUURING E, BROOKES S, MICHALIDES R, DICKSON C, ARNOLD A, AND PETERS G. (1991). D11S2S7, a putative oncogene on chromosome llql3, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1. Oncogene, 6, 439-444.
22. MANIATIS T, FRITSCH EF, AND SAMBROOK J. (1982). Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY.
23. MATSUSHIME H, ROUSSEL RA, ASHMUN RA, AND SHERR CJ. (1991). Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell, 65, 701-713.
24. MORI T, MIURA K, AOKI T, NISHIHIRA T, MORI S, AND NAKAMURA Y. (1994). Frequent somatic mutation of the MTSX I CDK4X (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma. Cancer Res., 54, 3396-3397.
25. MOTOKURA T, AND ARNOLD A. (1993). Cyclin D and oncogenesis (Review). Curr. Opin. Genet. Dev., 3, 5-10.
26. MULLER H, LUKAS J, SCHNEIDER A, WARTHOE P, BARTEK J, EILERS M, AND STRAUSS M. (1994). Cyclin D1 expression is regulated by the retinoblastoma protein. Proc. Natl Acad. Sci. USA, 91, 2945-2949.
27. NOBORI T, MIURA K, WU DJ, LOIS A, TAKABAYASHI K, AND CARSON DA. (1994). Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature, 368, 753-756.
28. PINES J. (1993). Cyclins and cyclin-dependent kinases: Take your partners. Trends Biochem. Sci., 18, 195-197.
29. SCHAUER IE, SIRIWARDANA S, LANGAN TA, AND SCLAFANI RA. (1994). Cyclin D1 overexpression vs. retinoblastoma inactivation: Implications for growth control evasion in non-small cell and small cell lung cancer. Proc. Natl Acad. Sci. USA, 91, 7827-7831.
30. SERRANO M, HANNON GJ, AND BEACH D. (1993). A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature, 366, 704-707.
31. SPRUCK III. CH, GONZ-ALEZZULUETA M, SHIBATA A, SIMONEAU AR, LIN M-F, GONZALES F, TSAI YC, AND JONES PA. (1994). pl6 gene in uncultured tumours. Nature, 370, 183-184.