In utero 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters reproductive morphology and function in female rat offspring

Toxicology and Applied Pharmacology

Volumn 133, Issue 2, 1995, Pages 285-294

  Earl Gray, Leon ^a   Ostby, Joseph S ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0029117772     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1995.1153     Document Type: Article

References (34)

1. Bjerke, D. L., Brown, T. J., MacLusky, N. J., Hochberg, R. B., and Peterson, R. E. (1994). Partial demasculinization and feminization of sex behavior in male rats by in alero and lactational exposure of male rats to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is not associated with alterations in estrogen receptor binding or volumes of sexually dimorphic brain nuclei. Toxicol. Appl. Pharmacol. 127, 258-267.
2. Bjerke, D. L., Sommer, R. J., Moore, R. W., and Peterson, R. E. (1993). Perinatal exposure of male rats to 2, 3, 7, 8-tetrachlorodibenzo-dioxin (TCDD) can decrease responsiveness to androgens in adulthood. Toxicologist 13, 104.
3. Botts, S. (1994). In Utero Exposure to 1 tig/kg Bodyweight of TCDD (2, 3, 7, 8), Pathology Summary Report, Project No. 63. Experimental Pathology Laboratories, Research Triangle Park, NC.
4. Chaffin, C. L., Roman, B. L., Peterson, R. E., and Hutz, R. J. (1994). Prenatal exposure to low-dose TCDD augments levels of uterine estrogen receptor mRNA in peripubertal rats. Biol. Reprod. 50, 76.
5. Chen, S. W., Roman, B. L., Saroya, S., Shinomiya, K., Moore, R. W., and Peterson, R. E. (1993). In utero exposure to 2, 3, 7, 8-tetrachlorodibenzo-/MÜoxin (TCDD) does not impair testosterone production by fetal rat testes. Toxicologist 13, 104.
6. Colborn, T., vom Saal, F. S., and Soto, A. M. (1993). Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ. Health Perspect. 101, 378-384.
7. DeVito, M. J., Thomas, T., Martin, E., Umbreit, T. H., and Gallo, M. A. (1992). Antiestrogenic action of 2, 3, 7, 8-tetrachlorodibenzo-p-di-oxin: Tissue-specific regulation of estrogen receptor in CD1 mice. Toxicol. Appl. Pharmacol. 113, 284-292.
8. Gray, L. E., Ostby, J. S., Ferrell, J. M., Sigmon, E. R., and Goldman, J. M. (1988). Methoxychlor induces estrogen-like alterations of behavior and the reproductive tract in the female rat and hamster: Effects on sex behavior, running wheel activity, and uterine morphology. Toxicol. Appl. Pharmacol. 96, 525-540.
9. Gray, L. E., Jr., Ostby, J., Ferrell, J., Sigmon, R., Cooper, R., Goldman, J., Slott, V., and Laskey, J. (1989). A dose-response analysis of methoxy-chlor-induced alterations of reproductive development and function in the rat. Fundam. Appl. Toxicol. 12, 92-108.
10. Gray, L. E. (1992). Chemical-induced alterations of sexual differentiation: A review of effects in humans and rodents. In Advances in Modern Environmental Toxicology, Vol. XXI, Chemically-Induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection (T. Colborn and C. Clement, Eds.), pp. 203-230. Princeton Sci. Pub., Princeton, NJ.
11. Gray, L. E., Marshall, R., Ostby, J., and Setzer, R. W. (1992a). Correlation of ejaculated sperm numbers with fertility in the rat. Toxicologist 12, 443.
12. Gray, L. E., Jr., Ostby, J. S., Kavlock, R. J., and Marshal, R. (1992b). Gonadal effects of fetal exposure to the azo dye congo red in mice: Infertility in female but not male offspring. Fundam. Appl. Toxicol. 19, 411-422.
13. Gray, L. E., and Ostby, J. S. (1993). The effects of prenatal administration of azo dyes on testicular development in the mouse: A structure-activity profile of dyes derived from benzidine, dimethylbenzidine, or dimeth-oxybenzidine. Fundam. Appl. Toxicol. 20, 177-183.
14. Gray, L. E., Ostby, J., Marshall, R., and Miller, D. (1993). Gestational busul fan (B) alters CNS, testicular and ovarian development and fertility in LE hooded rat offspring. Toxicologist 13, 75.
15. Gray, L. E., Jr., Ostby, J. S., and Kelce, W. (1994). Developmental effects of an environmental antiandrogen: The fungicide vinclozolin alters sex differentiation of the male rat. Toxicol. Appl. Pharmacol. 129, 46-52.
16. Gray, L. E., Kelce, W. R., Monosson, E., Ostby, J. S., and Birnbaum, L. S. (1995). Exposure to TCDD during development permanently alters reproductive function in male LE rats and hamsters: Reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicol. Appl. Pharmacol. 131, 108-118.
17. Hemsworth, B. N., and Jackson, H. (1962). Effect of busulphan on the foetal gonad. Nature 195, 816-817.
18. Henry, E. C., and Miller, R. K. (1986). The antiestrogen LY117018 is estrogenic in the fetal rat. Teratology 34, 59-63.
19. Henry, E. C., Miller, R. K., and Baggs, R. B. (1984). Direct fetal injections of diethylstilbestrol and 17/3-estradiol: A method for investigating their teratogenicity. Teratology 19, 297-304.
20. Hoar, R. M., and Monie, I. W. (1981). Comparative development of specific organ systems. In Developmental Toxicology (C. Kimmel and J. Buelke-Sam, Eds.), pp. 13-33. Raven Press, New York.
21. Johnson, L., Dickerson, R., Safe, S. H., Nyberg, C. L., Lewis, R. P., and Welsh, T. H. (1992). Reduced Leydigcell volume and function in adult rats exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin without a significant effect on spermatogenesis. Toxicology 76, 103-118.
22. Khera, K. S., and Ruddick, J. A. (1973). Polychlorodibenzo-p-dioxins: Perinatal effects and the dominant lethal test in Wistar rats. In Chlorodi-oxins-Origin and Fate (E. H. Blair, Ed.), pp. 70-84. Am. Chem. Soc., Washington, DC.
23. Mably, T., Moore, R. W., and Peterson, R. E. (1992a). In utero and lactational exposure of male rats to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. 1. Effects on androgenic status. Toxicol. Appl. Pharmacol. 114, 97-107.
24. Mably, T., Moore, R. W., Goy, R. W., and Peterson, R. E. (1992b). In utero and lactational exposure of male rats to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. 2. Effects on sexual behavior and the regulation of luteinizing hormone secretion in adulthood. Toxicol. Appl. Pharmacol. 114, 108-117.
25. Mably, T., Bjerke, D. L., Moore, R. W., Gendron-Fitzpatrick, A., and Peterson, R. E. (1992c). In utero and lactational exposure of male rats to 2, 3, 7, 8-tetrachlorodibenzo-/vdioxin. 3. Effects on spermatogenesis and reproductive capability. Toxicol. Appl. Pharmacol. 114, 118-126.
26. Moore, R. W., Potter, C. L., Theobald, H. M., Robinson, J. A., and Peterson, R. E. (1985). Androgenic deficiency in male rats treated with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 79, 99-111.
27. Murray, F. J., Smith, F. A., Nitschke, K. D., Humiston, C. G., Kociba, R. J., and Schwetz, B. A. (1979). Three-generation reproduction study in rats given 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) in the diet. Toxicol. Appl. Pharmacol. 50, 241-252.
28. Safe, S., Astroff, B., Harris, M., Zacharewski, T., Dickerson, R., Romkes, M., and Biegel, L. (1991). 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: Characterization and mechanism of action. Pharmacol. Toxicol. 69, 400-409.
29. Schardein, J. L. (1993). Hormones and hormonal antagonists. In Chemically Induced Birth Defects, pp. 271-339. Dekker, New York.
30. Smits-van Prooije, A. E., Lammers, J., Waalkens-Berendsen, D. H., Kulig, B. M., and Snoeij, N. J. (1993). Effects of the PCB 3, 4, 5, 3’, 4’, 5’-hexa-chlorobiphenyl on the reproduction capacity of Wistar rats. Chemo-sphere 27, 395-400.
31. Sodersten, P., and Larsson, K. (1975). Lordosis behavior and mounting behavior in male rats: Effects of castration and treatment with estradiol benzoate or testosterone propionate. Physiol. Behav. 14, 159-164.
32. Thomas, C. N., and Gerall, A. A. (1969). Effect of hour of operation on feminization of neonatally castrated male rats. Psychon. Sci. 16, 19-20.
33. Vannier, B., and Raynaud, J. P. (1980). Long-term effects of prenatal oestrogen treatment on genital morphology and reproductive function in the rat. J. Reprod. Fértil. 59, 43-49.
34. Voherr, H., Messer, R. H., Voherr, U. F., Jordan, S. W., and Kornfeld, M. (1979). Teratogenesis and carcinogenesis in rat offspring after transplacental and transmammary exposure to diethylstilbestrol. Biochem. Pharmacol. 28, 1865-1877.