Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

Cell

Volumn 82, Issue 4, 1995, Pages 643-653

  Hartwig, John H ^a   Bokoch, Gary M ^b   Carpenter, Christopher L ^c   Janmey, Paul A ^a   Taylor, Lance A ^a   Toker, Alex ^c   Stossel, Thomas P ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; F ACTIN; GELSOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; MUTANT PROTEIN; POLYPHOSPHOINOSITIDE; THROMBIN RECEPTOR; THROMBIN RECEPTOR ACTIVATING PEPTIDE;

ACTIN FILAMENT; ARTICLE; CELL LYSATE; CELL SUSPENSION; CONTROLLED STUDY; ELECTRON MICROSCOPY; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ACTIVATION;

EID: 0029117595     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(95)90036-5     Document Type: Article

References (46)

1. Thrombininduced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets
2. Activation of protein kinase C in rat basophilic leukemia cells stimulates increased production of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: correlation with actin polymerization
3. Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae
4. PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
5. Regulation of the phosphoinositide hydrolysis pathway in thrombinstimulated platelets by a pertussis toxin-sensitive guanine nucleotidebinding protein: evaluation of its contribution to platelet activation and comparisons with protein Gi
6. Histamine, actin-gelsolin binding, and polyphosphoinositides in human umbilical vein endothelial cells
7. 2+-independent pathways
8. The small GTP-binding protein rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells
9. Lack of correlation between changes in polyphosphoinositide levels and actin/gelsolin complexes in A431 cells treated with epidermal growth factor
10. 2+ is necessary for thrombin-induced platelet activation
11. The platelet cytoskeleton
12. Actin filament content and organization in unstimulated platelets
13. Mass and fatty acid composition of the 3-phosphorylated phosphatidylinositol bisphosphate isomer in stimulated human platelets
14. Synthesis of L-α-phosphatidy-d-myo-inositol 345-bisphosphate an important intracellular signalling molecule
15. c-src, phospholipase C, inositol-lipid, and diacylglycerol kinases with the cytoskeleton of thrombinstimulated platelets
16. Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts
17. Ras related proteins
18. Small GTP-binding proteins and the regulation of the actin cytoskeleton
19. Mechanism of actin rearrangements mediating platelet activation
20. 2+ buffers
21. Regulation of capZ, an actin capping protein of chicken muscle, by anionic phospholipids
22. Requirement for post-translational processing of Rac GTP-binding proteins for activation of human neutrophil NADPH oxidase
23. The kinetics of chemotactic peptide-induced change in F-actin content, distribution, and the shape of neutrophils
24. Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuron cell rounding by ADP ribosylation of the small GTP-binding protein Rho
25. Phosphoinositides and calcium as regulators of cellular actin assembly and disassembly
26. Gelsolin-polyphosphoinositide interaction: full expression of gelsolin-inhibiting function by polyphosphoinositides in vesicularform and inactivation by dilution, aggregation, or masking of the inositol head group
27. Phosphoinositide-binding peptides derived from the sequence of gelsolin and villin
28. Protein kinase C regulates the stimulated accumulation of 3-phosphorylated phosphoinositides in platelets
29. Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets, but reverses platelet aggregation
30. Human platelets form 3-phosphorylated phosphoinositides in response to alpha thrombin, U46619 or GTPγS
31. Reversible binding of actin to gelsolin and profilin in human platelet extracts
32. Phosphatidic acid is a specific activator of phosphatidylinositol4-phosphate kinase
33. Thymosin beta 4 (Tβ4) in activated platelets
34. Rac, rho, and cdc42 GTPase regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
35. How profilin promotes actin filament assembly in the presence of thymosin β4
36. A peptide ligand of the human thrombin receptor antagonizes α-thrombin and partially activates platelets
37. Induction of actin polymerization in permeabilized neutrophils: role of ATP
38. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
39. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
40. Isolation of a 5-kilodalton actin-sequestering peptide from human blood platelets
41. Diacylglycerol-stimulated formation of actin nucleation sites at plasma membranes
42. Involvement of platelet glycoprotein Ilb-Illa (αllb-β3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3',4'-bisphosphate
43. Evidence for two distinct phosphatidylinositol kinases in fibroblasts: evidence for cellular regulation
44. Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin
45. Activated phosphoinositide 3-kinase associates with membrane skeleton in thrombin-exposed platelets
46. Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein rho