The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

Nature Genetics

Volumn 11, Issue 1, 1995, Pages 17-26

  Marquis, Sandra T ^a   Rajan, Jayant V ^a   Wynshaw Boris, Anthony ^b   Xu, Junzhe ^c   Yin, Gui Ying ^c   Abel, Kenneth J ^c   Weber, Barbara L ^a   Chodosh, Lewis A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ESTRADIOL; MESSENGER RNA; POLYADENYLATED RNA; PROGESTERONE; SULFUR 35; TRANSFER RNA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER SUSCEPTIBILITY; CELL DIFFERENTIATION; CELL GROWTH; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE MUTATION; HORMONAL THERAPY; IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; OVARIECTOMY; OVARY CANCER; PRIORITY JOURNAL; TISSUE SPECIFICITY; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

ANIMAL; BASE SEQUENCE; BRCA1 PROTEIN; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; EMBRYO AND FETAL DEVELOPMENT; EPITHELIUM; ESTRADIOL; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; IN SITU HYBRIDIZATION; LACTATION; MALE; MAMMAE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; ORGAN SPECIFICITY; OVARIECTOMY; PARITY; PREGNANCY; PROGESTERONE; SEX MATURATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION FACTORS;

EID: 0029115660     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng0995-17     Document Type: Article

References (29)

1. Miki, Y. et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66-71 (1994).
2. Easton, D. F., Bishop, D. T., Ford, D. & Crockford, G. P., Linkage consortium. Genetic linkage analysis in familial breast and ovarian cancer. Results from 214 families. Am. J. hum. Genet. 52, 678-701 (1993).
3. Smith, S. A., Easton, D. G., Evans, D. G. R. & Ponder, B. A. J. Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome. Nature Genet. 2, 128-131 (1992).
4. Thompson, M. E., Jensen, R. A., Obermiller, P. S., Page, D. L. & Holt, J. T. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nature Genet. 9, 444-450 (1995).
5. Merajver, S. D. et al. Somatic mutations in the Brca1 gene in sporadic ovarian tumours. Nature Genet. 9, 439-443 (1995).
6. Hosking, L. et al. A somatic Brca1 mutation in an ovarian tumor. Nature Genet. 9, 343-344 (1995).
7. Futreal, P. A. et al. Brca1 mutations in primary breast and ovarian carcinomas. Science 266, 120-122 (1994).
8. Ford, D. et al. Risks of cancer in Brca1-mutation carriers. Lancet 343, 692-695 (1994).
9. Russo, J. & Russo, I. H. Development pattern of human breast and susceptibility to carcinogenesis. Eur. J. Cancer Prev. 2 (Suppl. 3), 85-100 (1993).
10. Schmid, P., Lorenz, A., Hameister, H. & Montenarh, M. Expression of p53 during mouse embryogenesis. Development 113, 857-865 (1991).
11. Gavin, B. J. & McMahon, A. P. Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland. Molec. Cell. Biol. 12, 2418-2423 (1992).
12. Buhler, T. A., Dale, T. C., Kieback, C., Humphreys, R. C. & Rosen, J. M. Localization and quantification of Wnt-2 gene expression in mouse mammary development. Dev. Biol. 155, 87-96 (1993).
13. Morrison, B. W. & Leder, P. neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors. Oncogene 9, 3417-3426 (1994).
14. Hobbs, A. A., Richards, D. A., Kessler, D. J. & Rosen, J. M. Complex hormonal regulation of rat casein gene expression. J. Biol. Chem. 257, 3598-3605 (1982).
15. McMaster, M. T., Teng, C. T., Dey, S. K. & Andrews, G. K. Lactoferrin in the mouse uterus: Analyses of the preimplantation period and regulation by ovarian steroids. Molec. Endocrinol. 6, 101-111 (1992).
16. Walmer, D. K., Wrona, M. A., Hughes, C. L. & Nelson, K. G. Lactoferrinexpression in the mouse reproductive tract during the natural estrous cycle: correlation with circulating estradiol and progesterone. Endocrinology 131, 1458-1466 (1992).
17. Almon, E. et al. Tissue-specific expression of the p53 suppressor gene. Devel. Biol. 156, 107-116 (1993).
18. Merritt, A. J. et al. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res. 54, 614-617 (1994).
19. Rogel, A., Popliker, M., Webb, C. G. & Oren, M. p53 cellular tumor antigen: Analysis of mRNA levels in normal adult tissues, embryos, and tumors. Molec. cell. Biol. 5, 2851-2855 (1985).
20. Reich, N. C. & Levine, A. J. Growth regulation of a cellular tumour antigen, p53, in nontransformed cells. Nature 308, 199-201 (1984).
21. Lane, D. P. DPp53 and human cancers. Br. med. Bull. 50, 582-599 (1994).
22. Mercer, W. E., Avignolo, C. & Baserga, R. Role of the p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies. Molec. cell. Biol. 4, 276-281 (1984).
23. Russo, J., Tay, L. K. & Russo, I. H. Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res. Treat. 2, 5-73 (1982).
24. McGregor, H. et al. Breast cancer incidence among atomic bomb survivors, Hiroshima and Nagasaki, 1950-69. J. nat Cancer Inst. 59, 799-811 (1977).
25. Boice, J. D., & Monson, R. R. Breast cancer in women after repeated fluoroscopic examinations of the chest. J. nat. Cancer Inst. 59, 823-832 (1977).
26. MacMahon, B. et al. Age at first birth and breast cancer risk. Bull. World Hlth. Org. 43, 209-21 (1970).
27. Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J. & Rutter, W. J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18, 5294-5299 (1979).
28. Engelhardt, J. F. et al. Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nature Genet. 2, 240-248 (1992).
29. Wilkinson, D. G. In situ hybridization: a practical approach (IRL Press, Oxford, 1992).