Acute blockade of nitric oxide synthase inhibits renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats

Journal of Clinical Investigation

Volumn 96, Issue 1, 1995, Pages 482-490

  Danielson, L A ^a   Conrad, K P ^a,b  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

angiotensin II; cyclic guanosine 3',5' monophosphate; glomerular filtration rate; renal blood flow; renal vascular resistance

Indexed keywords

ANGIOTENSIN; CYCLIC GMP; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GLOMERULUS FILTRATION RATE; KIDNEY BLOOD FLOW; KIDNEY CLEARANCE; KIDNEY FUNCTION; KIDNEY PLASMA FLOW; KIDNEY VASCULAR RESISTANCE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT; ULTRAFILTRATION; VASODILATATION;

EID: 0029115365     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118059     Document Type: Article

References (47)

1. Conrad, K. P. 1992. Renal changes in pregnancy. Urol. Ann. 6:313-340.
2. MacGillivray, I., G. A. Rose, and B. Rowe. 1969. Blood pressure survey in pregnancy. Clin. Sci. 37:395-407.
3. Conrad, K. P. 1984. Renal hemodynamics during pregnancy in chronically catheterized, conscious rats. Kidney Int. 26:24-29.
4. Conrad, K. P., and M. C. Colpoys. 1986. Evidence against the hypothesis that prostaglandins are the vasodepressor agents of pregnancy. J. Clin. Invest. 77:236-245.
5. Baylis, C. 1987. Renal effects of cyclooxygenase inhibition in the pregnant rat. Am. J. Physiol. 253:F158-F163.
6. Conrad, K. P., and M. J. Dunn. 1987. Renal synthesis and urinary excretion of eicosanoids during pregnancy in rats. Am. J. Physiol. 253:F1197-F1205.
7. Conrad, K. P. 1987. Possible mechanisms for changes in renal hemodynamics during pregnancy: studies from animal models. Am. J. Kidney Dis. 9:253- 259.
8. Conrad, K. P., and K. A. Vernier. 1989. Plasma level, urinary excretion. and metabolic production of cGMP during gestation in rats. Am. J. Physiol. 257:R847-R853.
9. Conrad, K. P., G. M. Joffe, H. Kruszyna, R. Kruszyna, L. G. Rochelle, R. P. Smith, J. E. Chavez, and M. D. Mosher. 1993. Identification of increased nitric oxide biosynthesis during pregnancy in rats. FASEB (Fed. Am. Soc. Exp. Biol.) J. 7:566-571.
10. Conrad, K. P., M. Gellai, W. G. North, and H. Valtin. 1986. Influence of oxytocin on renal hemodynamics and electrolyte and water excretion. Am. J. Physiol. 251:F290-F296.
11. Führ, J., J. Kaczmarczyk, and C. D. Krüttgen. 1955. Eine einfache colorimetrische Methode zur Inulinbestimmung für Nieren-Clearance-Untersuchungen bei Stoffwechselgesunden und Diabetikern. Klin. Wochenschr. 33:729-730.
12. Smith, H. W., N. Finkelstein, L. Alimmosa, B. Crawford, and M. Graber. 1945. The renal clearances of substituted hippuric acid derivatives and other aromatic acids in dog and man. J. Clin. Invest. 24:388-404.
13. Bradford, M. 1976. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principal of protein-dye binding. Anal. Biochem. 72:248-254.
14. Zar, J. H. 1984. Biostatistical Analysis. Prentice Hall, Englewood Cliffs, NJ.
15. Lindheimer, M. D., and A. I. Katz. 1991. The kidney and hypertension in pregnancy. In The Kidney. B. M. Brenner and F. C. Rector, (editors). W. B. Saunders, Philadelphia, PA.
16. Atherton, J. C., J. M. Dark, H. O. Garland, M. R. A. Morgan, J. Pidgeon, and S. Soni. 1982. Changes in water and electrolyte balance, plasma volume and composition during pregnancy in the rat. J. Physiol. (Lond.). 330:81-93.
17. Reckelhoff, J. F., L. Samsall, and C. Baylis. 1989. Failure of an acute 10-15% plasma volume expansion in the virgin female rat to mimic the increased glomerular filtration rate (GFR) and altered glomerular hemodynamics seen at midterm pregnancy. Clin. Exp. Hypertens. B8:533-549.
18. Gellai, M., J. H. Silverstein, J.-C. Hwang, F. T. LaRochelle, Jr., and H. Valtin. 1984. Influence of vasopressin on renal hemodynamics in conscious Brattleboro rats. Am. J. Physiol. 246:F819-F827.
19. Conrad, K. P., M. Gellai, W. G. North, and H. Valtin. 1993. Influence of oxytocin on renal hemodynamics and sodium excretion. Ann. NY Acad. Sci. 689:346-362.
20. Davison, J. M. 1985. The effect of pregnancy on kidney function in renal allograft recipients. Kidney Int. 27:74-79.
21. Baylis, C., and R. C. Blantz. 1985. Tubuloglomerular feedback activity in virgin and 12-day-pregnant rats. Am. J. Physiol. 249:F169-F173.
22. Chesley, L. C., and I. H. Tepper. 1967. Effects of progesterone and estrogen on the sensitivity to angiotensin II. J. Clin. Endocrinol. Metab. 27:576- 581.
23. Atallah, A. N., J. A. G. Guimaraes, M. Gebara, D. R. Sustovich, T. R. Martinez, and L. Camano. 1988. Progesterone increases glomerular filtration rate, urinary kallikrein excretion and uric acid clearance in normal women. Braz. J. Med. Biol. Res. 21:71-74.
24. Atherton, J. C., D. Bu'lock, and S. C. Pirie. 1982. The effect of pseudopregnancy on glomerular filtration rate and salt and water reabsorption in the rat. J. Physiol. (Lond.). 324:11-20.
25. Baylis, C. 1982. Glomerular ultrafiltration in the pseudopregnant rat. Am. J. Physiol. 234:F300-F305.
26. 2, plasma renin activity, and renal function throughout rabbit pregnancy. J. Lab. Clin. Med. 99:239-246.
27. Brown, G. P., and R. C. Venuto. 1990 Eicosanoid production in rabbit vascular tissues and placentas. Am. J. Physiol. 258:E418-E422.
28. Conrad, K. P., S. A. Barrera, P. A. Friedman, and V. M. Schmidt. 1991. Evidence for attenuation of myo-inositol uptake, phosphoinositide turnover, and inositol phosphate production in aortic vasculature of gravid rats. J. Clin. Invest. 87:1700-1709.
29. Bachmann, S., and P. Mundel. 1994. Nitric oxide in the kidney: synthesis, localization and function. Am. J. Kidney Dis. 24:112-129.
30. Gardiner, S. M., A. M. Compton, T. Bennett, R. M. J. Palmer, and S. Moncada. 1990. Control of regional blood flow by endothelium-derived nitric oxide. 15:486-492.
31. Baylis, C., P. Harton, and K. Engels. 1990. Endothelial derived relaxing factor controls renal hemodynamics in the normal rat kidney. J. Am. Soc. Nephrol. 1:875-881.
32. Radermacher, J., B. Klanke, H.-J. Schurek, H. F. Stolte, and J. C. Frölich. 1992. Importance of NO/EDRF for glomerular and tubular function: studies in the isolated perfused rat kidney. Kidney Int. 41:1549-1559.
33. Baylis, C., K. Engels, L. Samsell, and P. Harton. 1993. Renal effects of acute endothelial-derived relaxing factor blockade are not mediated by angiotensin II. Am. J. Physiol. 264:F74-F78.
34. G-nitro-L-arginine as affected by blockade of pressor mechanisms mediated by the sympathetic nervous system, angiotensin, prostanoids and vasopressin. J. Pharmacol. Exp. Ther. 261:240-245.
35. Lacolley, P. J., S. J. Lewis, and M. J. Brody. 1991. Role of sympathetic nerve activity in the generation of vascular nitric oxide in urethane-anesthetized rats. Hypertension (Dallas). 17:881-887.
36. G-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. 70:607-611.
37. Deng, A., and C. Baylis. 1993. Locally produced EDRF controls preglomerular resistance and ultrafiltration coefficient. Am. J. Physiol. 264:F212-F215.
38. Zatz, R., and G. De Nucci. 1991. Effects of acute nitric oxide inhibition on rat glomerular microcirculation. Am. J. Physiol. 261:F360-F363.
39. Ohishi, K., P. K. Carmines, E. W. Inscho, and L. G. Navar 1992. EDRF- angiotensin II interactions in rat juxtamedullary afferent and efferent arterioles. Am. J. Physiol. 263:F900-F906.
40. Imig, J. D., and R. J. Roman. 1992. Nitric oxide modulates vascular tone in preglomerular arterioles. Hypertension (Dallas). 19:770-774.
41. Arnal, J.-F., L. Warin, and J.-B. Michel. 1992. Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase. J. Clin. Invest. 90:647-652.
42. Whittemore, S. L., M. K. McLaughlin, S. T. Davidge, and K. P. Conrad. 1994. Effect of pregnancy on aortic cGMP production and vasorelaxation in the rat. Hypertension in Pregnancy. 13:227-244.
43. Brown, G. P., and R. C. Venuto. 1991. Renal blood flow response to angiotensin II infusions in conscious pregnant rabbits. Am. J. Physiol. 261:F51- F59.
44. Masilamani, S., and C. Baylis. 1992. J. Am. Soc. Nephrol. 3:566. (Abstr.)
45. Chesley, L. C., R. M. Wynn, and N. I. Silverman. 1963. Renal effects of angiotensin II infusions in normotensive pregnant and nonpregnant women. Circ. Res. XIII:232-238.
46. Gilson, G. J., M. D. Mosher, and K. P. Conrad. 1992. Systemic hemodynamics and oxygen transport during pregnancy in chronically instrumented, conscious rats. Am. J. Physiol. 263:H1911-H1918.
47. Chesley, L. C., and G. M. Duffus. 1971. Preeclampsia, posture and renal function. 38:1-5.