Enzyme-independent formation of nitric oxide in biological tissues

Nature Medicine

Volumn 1, Issue 8, 1995, Pages 804-809

  Zweier, Jay L ^a   Wang, Penghai ^a   Samouilov, Alexandre ^a   Kuppusamy, Periannan ^b  

^a Laboratory of Cellular and Molecular Biology   (United States)

^b JOHNS HOPKINS BAYVIEW MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE;

ANIMAL EXPERIMENT; ARTICLE; BIOSYNTHESIS; HEART MUSCLE INJURY; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE INJURY;

ANIMAL; ELECTRON SPIN RESONANCE SPECTROSCOPY; FEMALE; HEME; HYDROGEN-ION CONCENTRATION; IN VITRO; MAGNETIC RESONANCE SPECTROSCOPY; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NITRIC OXIDE; NITRIC-OXIDE SYNTHASE; NITRITES; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0029114339     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm0895-804     Document Type: Article

References (22)

1. Moncada S., Palmer, R.M. Jr. and Higgs, E.A. Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmac. Rev. 43, 109-142 (1991).
2. Furchgott, R.F. and Zawadzki, J.V. The obligatory role of endothelial cells on the relaxation of arterial muscle by acetylcholine. Nature 288, 373-376 (1980).
3. Palmer, R.M. Jr., Ferridge, A.G. and Moncada, S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327, 524-526 (1987).
4. Ignarro, L.J., Byms, R.E., Buga, G.M. and Wood, K.S. Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties. Circ. Res. 61, 866-879 (1987).
5. Furchgott, R.F. and Vanhoutte, P.M. Endothelium-derived relaxing and contracting factors. FASEB J. 3, 2007-2018 (1989).
6. Marietta, M.A., Yoon, P.S., Iyengar, R., Leaf, C.D. and Wishnok, J.S. Macrophage oxidation of L-arginine to nitrite and nitrate: Nitric oxide is an intermediate. Biochemistry 27, 8706-8711 (1988).
7. Bredt, D.S. et al., Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 351, 714-718 (1991).
8. Bredt, D.S. and Synder, S.H. Nitric oxide: A novel neuronal messenger. Neuron 8, 3-11 (1992).
9. Moncada, S., Palmer, R.M. Jr. and Higgs, E.A., Biosynthesis of nitric oxide from larginine: A pathway for the regulation of cell function and communication. Biochem. Pharmac. 38, 1709-1715 (1989).
10. Garthwaite, J. Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci. 14, 60-67 (1991).
11. Langrehr, J.M., Hoffman, R.A., Lancaster, J.R. Jr. and Simmons, R.L. Nitric oxide, a new endogenous immunomodulator. Transplantation 55, 1205-1212 (1993).
12. Beckman, J.S., Beckman, T.W., Chen, J., Marshall, P.A. and Freeman, B.A. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc. natn. Acad. Sci. U.S.A. 87, 1620-1624 (1990).
13. Zweier, J.L., Wang, P. and Kuppusamy, P., Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy. J. biol. Chem. 270, 304-307 (1995).
14. Lancaster, J.R. Jr. et al. Detection of nitric oxide by electron paramagnetic resonance spectroscopy during rejection of rat heart allograft. J. biol. Chem. 267, 10994-10998 (1992).
15. Lai, C.S. and Komarov, A.M. Spin trapping of nitric oxide produced in vivo in septic-shock mice. FEBS Lett. 345, 120-124 (1994).
16. Shinobu, L.A., Jones, S.G. and Jones, M.M. Sodium N-methyl-D-glucamine dithio- carbamate and cadmium intoxication. Acta Pharmacol. Toxicol. 54, 189-194 (1984).
17. Zweier, J.L., Measurement of superoxide-derived free radicals in the reperfused heart: Evidence for a free radical mechanism of reperfusion injury. J. biol. Chem. 263, 1353-1357 (1988).
18. Zweier, J.L. et al. Measurement and characterization of postischemic free radical generation in the isolated perfused heart. J. biol. Chem. 264, 18890-18895 (1989).
19. Furfine, E.S., Harmon, M.F., Paith, J.E. and Garvey, E.P. Selective inhibition of constitutive nitric oxide synthase by L-β-nitroarginine. Biochemistry 32, 8512-8517 (1993).
20. Zweier, J.L. and Jacobus, W.E. Substrate-induced alterations of high energy phosphate metabolism and contractile function in the perfused heart. J. biol. Chem. 262, 8015-8021 (1987).
21. Garside, C. A chemiluminescent technique for the determination of nanomolar concentrations of nitrate and nitrite in seawater. Marine Chem. 11, 159-167 (1982).
22. Chzhan, M., Shteynbuk, M., Kuppusamy, P. and Zweier, J.L., An optimized L-band ceramic resonator for EPR imaging of biological samples. J. Magnet. Reson. A105, 49-53 (1993).