Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1

Molecular Brain Research

Volumn 32, Issue 2, 1995, Pages 233-240

  Lahiri, Debomoy K ^a,b   Nall, Christina ^a  

^a Institute of Psychiatric Research   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Differentiation; Gene regulation; Growth factor; Interleukin 1; PC12 cell; Promoter; Retinoic acid; Amyloid precursor protein

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BASIC FIBROBLAST GROWTH FACTOR; CHLORAMPHENICOL ACETYLTRANSFERASE; GROWTH FACTOR; INTERLEUKIN 1; NERVE GROWTH FACTOR; PHORBOL 12 ACETATE 13 MYRISTATE; RETINOIC ACID;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE ACTIVATION; GENE ACTIVITY; GENETIC TRANSFECTION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; RAT; RECOMBINANT GENE; REPORTER GENE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMAL; CELLS, CULTURED; GENE EXPRESSION REGULATION; INTERLEUKIN-1; NERVE GROWTH FACTORS; PC12 CELLS; PHORBOL ESTERS; PROMOTER REGIONS (GENETICS); RATS; SUPPORT, U.S. GOV'T, P.H.S.; TRETINOIN; UP-REGULATION;

ANIMALIA; FELIS CATUS;

EID: 0029114162     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-328X(95)00078-7     Document Type: Article

References (44)

1. Basic fibroblast growth factor prevents death of lesioned cholinergic neuron in vivo
2. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated transacting factor
3. Localization of amyloid β-protein mRNA in brains from patients with Alzheimer's disease
4. Structural features of the 5′ upstream regulatory region of the gene encoding rat amyloid precursor protein
5. In situ hybridization of nucleus basalis neurons shows increased β-amyloid mRNA in Alzheimer's disease
6. Nerve growth factor does not influence the expression of β amyloid precursor protein mRNA in rat brain: in vivo and in vitro studies
7. Increased expression of beta-amyloid precursor and microtubule-associated protein tau during the differentiation of murine embryonal carcinoma cells
8. Nerve growth factor-induced neuronal differentiation is accompanied by differential induction and localization of the amyloid precursor protein (APP) in PC12 cells and variant PC12S cells
9. Interleukin 1 regulates synthesis of amyloid β-protein precursor mRNA in human endothelial cells
10. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells
11. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
12. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
13. Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide
14. Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory changes
15. Positive and negative regulatory elements for the expression of the Alzheimer's disease amyloid precursor-encoding gene in mouse
16. Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimer's disease
17. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
18. Retinoic acid induced differentiated neuroblastoma cells show increased expression of the beta A4 amyloid gene of Alzheimer's disease and an altered splicing patterns
19. Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates
20. Characterization of the 5′ -end region and the first two exons of the beta-protein precursor gene
21. Differential expression of the gene promoter encoding beta amyloid protein precursor in presence of phorbol esters
22. The promoter activity of the gene encoding the Alzheimer β-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences
23. Characterization of two blocks of cis-acting regulatory elements modulating the expression of the gene encoding the Alzheimer's Amyloid Precursor Proteins
24. Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40
25. Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements
26. The preA4695 precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons
27. The nerve growth factor 35 years later
28. Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve
29. Protein-DNA interactions in the promoter region of the amyloid precursor protein (APP) gene in human cortex
30. Potentiation of synaptic transmission in the hippocampus by phorbol esters
31. Nerve growth factor increases mRNA levels for the prion protein and the β-amyloid protein precursor in developing hamster brain
32. Expression of the Alzheimer amyloid precursor gene transcripts in the human brain
33. The Alzheimer amyloid precursor-related transcript lacking the β/A4 sequence is specifically increased in Alzheimer's disease brain
34. Effect of growth factors and cytokines on expression of amyloid β protein precursor mRNAs in cultured neural cells
35. Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease
36. The expression of the amyloid protein (APP) is regulated by two GC-elements in the promoter
37. The amyloid β-protein precursor promoter: A region essential for transcriptional activity contains a nucular factor binding domain
38. Fibroblast growth factor induces β-Amyloid precursor mRNA in glila but not neuronal cultured cells
39. Formation of beta-amyloid protein deposits in brains of transgenic mice
40. The promoter of Alzheimer's disease amyloid A4 precursor gene
41. Normal and abnormal biology of the β-amyloid precursor protein
42. Basic fibroblast growth factor in Alzheimer's disease
43. Regulatory region of human amyloid precursor protein (APP) gene promotes neuron-specific gene expression in the CNS of transgenic mice
44. Genomic organization of the human amyloid beta-protein precursor gene