Mouse models of Tay–Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism

Nature Genetics

Volumn 11, Issue 2, 1995, Pages 170-176

  Sango, Kazunori ^a   Yamanaka, Shoji ^a,f   Hoffmann, Alexander ^b   Okuda, Yasuharu ^a   Grinberg, Alexander ^c   Westphal, Heiner ^c   McDonald, Michael P ^d   Crawley, Jacqueline N ^d   Sandhoff, Konrad ^b   Suzuki, Kinuko ^e   Proia, Richard L ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF BONN   (Germany)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

^f YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GANGLIOSIDE;

ANIMAL CELL; ARTICLE; DEGENERATIVE DISEASE; GENE DISRUPTION; LIPID METABOLISM; METABOLIC DISORDER; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SANDHOFF DISEASE; TAY SACHS DISEASE;

ANIMAL; BETA-N-ACETYLHEXOSAMINIDASE; BRAIN; CARBOHYDRATE SEQUENCE; COMPARATIVE STUDY; DISEASE MODELS, ANIMAL; GANGLIOSIDES; HUMAN; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; NEURONS; PHENOTYPE; RESTRICTION MAPPING; SANDHOFF DISEASE; SPINAL CORD; STEM CELLS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TAY-SACHS DISEASE;

EID: 0029113867     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1095-170     Document Type: Article

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