Synthesis, Structure, and Pharmacological Evaluation of the Stereoisomers of Furnidipine

Journal of Medicinal Chemistry

Volumn 38, Issue 15, 1995, Pages 2830-2841

  Alajarin, Ramón ^a   Vaquero, Juan J ^a   Alvarez Builla, Julio ^a   Pastor, Manuel ^a   Sunkel, Carlos ^b   de Casa Juana, Miguel Fau ^b   Priego, Jaime ^b   Statkow, Peter R ^c   Sanz Aparicio, Julia ^d   Fonseca, Isabel ^d  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b Cermol SA ^*  (Spain)

^c Centre de Recherche Moleculaire   (Switzerland)

^d INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMLODIPINE; BENZYLSULFONYL FLUORIDE; CALCIUM CHANNEL BLOCKING AGENT; DIHYDROPYRIDINE DERIVATIVE; FURNIDIPINE; ISRADIPINE; NICARDIPINE; NIFEDIPINE; NIMODIPINE; NITRENDIPINE; TETRAHYDROFURAN DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CHIRALITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENANTIOMER; GUINEA PIG; HEART ARRHYTHMIA; HEART REINFARCTION; HUMAN; ILEUM; LIGAND BINDING; NONHUMAN; PHASE 2 CLINICAL TRIAL; RACEMIC MIXTURE; RAT; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; STUNNED HEART MUSCLE; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING, COMPETITIVE; BRAIN; CALCIUM CHANNEL BLOCKERS; CHEMISTRY, PHYSICAL; CRYSTALLOGRAPHY, X-RAY; DIHYDROPYRIDINES; DRUG EVALUATION, PRECLINICAL; GUINEA PIGS; HEART; ISRADIPINE; KINETICS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; MYOCARDIAL CONTRACTION; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRITIUM;

EID: 0029113797     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00015a005     Document Type: Article

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