Nonclassical 2,4-Diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline Antifolates: Synthesis and Biological Activities

Journal of Medicinal Chemistry

Volumn 38, Issue 18, 1995, Pages 3660-3668

  Gangjee, Aleem ^a   Zaveri, Nurulain ^b   Kothare, Mohit ^a   Queener, Sherry F ^c  

^a DUQUESNE UNIVERSITY   (United States)

^b SRI INTERNATIONAL   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 6 (AMINOMETHYL) 5,6,7,8 TETRAHYDROQUINAZOLINE DERIVATIVE; 2,4 DIAMINO 6 [[(2',5' DIMETHOXYPHENYL)METHYLAMINO]METHYL] 5,6,7,8 TETRAHYDROQUINAZOLINE; ANTINEOPLASTIC AGENT; ANTIPROTOZOAL AGENT; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; TRIMETHOPRIM; TRIMETREXATE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIVER; NONHUMAN; PNEUMOCYSTIS CARINII; RAT; TOXOPLASMA GONDII; TUMOR CELL LINE;

ANIMAL; ANTINEOPLASTIC AGENTS; DRUG DESIGN; FOLIC ACID ANTAGONISTS; LIVER; PNEUMOCYSTIS CARINII; QUINAZOLINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TOXOPLASMA;

EID: 0029113718     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00018a027     Document Type: Article

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