Treatment of marrow stroma with interferon-α restores normal β1 integrin-dependent adhesion of chronic myelogenous leukemia hematopoietic progenitors: Role of MIP-1α

Journal of Clinical Investigation

Volumn 96, Issue 2, 1995, Pages 931-939

  Bhatia, Ravi ^a   McGlave, Philip B ^a   Verfaillie, Catherine M ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIV OF MINNESOTA HOSP AND CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYUREA; INTEGRIN; MACROPHAGE INFLAMMATORY PROTEIN 1; RECOMBINANT ALPHA INTERFERON;

ARTICLE; CELL ADHESION; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HEMATOPOIESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOMODULATION; PRIORITY JOURNAL; PROTEIN INDUCTION; RECEPTOR UPREGULATION; STEM CELL;

ADIPOSE TISSUE; ANTIGENS, CD29; BONE MARROW; BONE MARROW CELLS; CELL ADHESION; CELLS, CULTURED; CONNECTIVE TISSUE; CONNECTIVE TISSUE CELLS; CYTOKINES; HEMATOPOIETIC STEM CELLS; HUMAN; INTEGRINS; INTERFERON ALFA-2A; LEUKEMIA, MYELOID, CHRONIC-PHASE; MACROPHAGE INFLAMMATORY PROTEIN-1; MONOKINES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR STEM CELLS;

EID: 0029111697     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118141     Document Type: Article

References (48)

1. Eaves, A. C., J. D. Cashman, L. A. Gaboury, D. K. Kalousek, and C. J. Eaves. 1986. Unregulated proliferation of primitive chronic myelogenous leukemia progenitors in the presence of normal marrow adherent cells. Proc. Natl. Acad. Sci. USA. 83:5306-5310.
2. Cashman, J., A. C. Eaves, and C. J. Eaves. 1985. Regulated proliferation of primitive hematopoietic progenitors in long-term human marrow cultures. Blood. 66:1002-1005.
3. Verfaillie, C. M. 1992. Direct contact between human primitive hematopoietic progenitors and bone marrow stroma is not required for long term in vitro hematopoiesis. Blood. 79:2821-2826.
4. Cashman, J. D., A. C. Eaves, E. W. Raines, R. Ross, and C. J. Eaves. 1990. Mechanisms that regulate the cell cycle status of very primitive hematopietic cells in long-term human marrow cultures. I. Stimulatory role of a variety of mesenchymal cell activators and inhibitory role of TGF-β. Blood. 75:96-101.
5. Broxmeyer, H. E., B. Sherry, L. Lu, S. Cooper, K.-O. Oh, P. Tekamp-Olson, B. S. Kwon, and A. Cerami. 1990. Enhancing and suppressing effects of recombinant murine macrophage inflammatory protein on colony formation in vitro by bone marrow myeloid progenitor cells. Blood. 76:1110-1116.
6. Massagne, J., S. Chelfitz, F. T. Boyd, and J. L. Andres. 1990. TGF-β receptors and TGF-β binding proteoglycans: recent progress in identifying their functional properties. Ann. N. Y. Acad. Sci. 593:59-72.
7. Graham, G., E. Wright, R. Hewick, S. Wolpe, N. Wilkie, D. Donaldson, S. Lorimore, and I. Pragnell. 1990. Identification and characterization of an inhibitor of hematopoietic stem cell proliferation. Nature (Lond.). 344:442-444.
8. Hurley, R. W., J. B. McCarthy, and C. M. Verfaillie. 1993. Direct contact with bone marrow stroma has negative regulatory effects on hematopoietic progenitors. Blood. 82 (10 Suppl. 1):21A.
9. Verfaillie, C. M., J. B. McCarthy, and P. B. McGlave. 1992. Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia: decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV. J. Clin. Invest. 90:1232-1239.
10. Bhatia, R., E. A. Wayner, P. B. McGlave, and C. M. Verfaillie. 1994. Interferon-α restores normal adhesion of chronic myelogenous leukemia hematopoietic progenitors to bone marrow stroma by correcting impaired β1 integrin receptor function. J. Clin. Invest. 94:384.
11. Verfaillie, C. M., J. B. McCarthy, and P. B. McGlave. 1991. Differentiation of primitive human multipotent hematopoietic progenitors into single lineage clonogenic progenitors is accompanied by alterations in their adhesion to fibronectin. J. Exp. Med. 174:693-703.
12. Teixedo, J., M. E. Hemler, J. S. Greenberger, and P. Anklesaria. 1992. Role of β1 and β2 integrins in the adhesion of human CD34+ stem cells to bone marrow stroma. J. Clin. Invest. 90:358-367.
13. Simmons, P. J., B. Masinovsky, B. M. Longenecker, R. Derenson, B. Torok-Storb, and W. M. Gallatin. 1992. Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells. Blood. 80:388-395.
14. Williams, D. A., M. Rios, C. Stephens, and V. P. Patel. 1991. Fibronectin and VLA-4 in hematopoietic stem cell-microenvironment interactions. Nature (Lond.). 352:438-441.
15. Verfaillie, C. M., J. B. McCarthy, and P. B. McGlave. 1991. Primitive and committed human hematopoietic progenitors use different combinations of integrins in their interaction with bone marrow stroma. Blood. 78:255a. (Abstr.)
16. Gordon, M. Y., C. R. Dowding, G. P. Riley, J. M. Goldman, and M. F. Greaves. 1984. Altered adhesive interactions with marrow stroma of hematopoietic progenitor cells in chronic myelogenous leukemia. Nature (Lond.). 328:342-344.
17. Talpaz, M., H. M. Kantarjian, R. Kurzrock, J. M. Trujillo, and J. U. Gutterman. 1991. Interferon-alpha produces sustained cytogenetic responses in chronic myelogenous leukemia Philadelphia chromosome positive patients. Ann. Intern. Med. 114:532-538.
18. Upadhyaya, G., S. C. Guba, S. A. Sin, A. P. Feinberg, M. Talpaz, H. M. Kantarjian, A. B. Deisseroth, and S. G. Emerson. 1991. Interferon-alpha restores the deficient expression of the cytoadhesion molecule lymphocyte function antigen-3 by chronic myelogenous leukemia progenitor cells. J. Clin. Invest. 88:2131-2136.
19. Dowding, C., A.-P. Guo, J. Osterholz, M. Sickowski, J. Goldman, and M. Gordon. 1991. Interferon-α overrides the deficient adhesion of chronic myelogenous leukemia primitive progenitor cells to bone marrow stromal cells. Blood. 78:499-505.
20. Evans, S. S., R. P. Collea, M. M. Appenheimer, and S. O. Golnick. 1993. Interferon-α induces the expression of L-Selectin homing receptors in human B lymphoid cells. J. Cell Biol. 123:1889-1898.
21. Osborn, L. 1990. Leukocyte adhesion to endothelium in inflammation. Cell. 62:3-6.
22. Dustin, M. L., R. Rothlein, A. K. Bhan, C. A. Dinarella, and T. A. Springer. 1986. Induction by IL-1 and IFN-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 137:245-254.
23. Duncan, M. R., and B. Berman. 1989. Differential regulation of glycosaminioglycan, fibronectin, and collagen production in cultured human dermal fibroblasts by Interferon-alpha, -beta, and -gamma. Arch. Dermatol. Res. 281:11-18.
24. Verfaillie, C., K. Blakholmer, and P. McGlave. 1990. Purified primitive human hematopoietic progenitors with long-term in vitro repopulating capacity adhere selectively to irradiated bone marrow stroma. J. Exp. Med. 179:509-520.
25. Verfaillie, C. M., W. J. Miller, K. Boylan, and P. B. McGlave. 1992. Selection of benign primitive hematopoietic progenitors in chronic myelogenous leukemia on the basis of HLA-DR expression. Blood. 79:1003-1010.
26. Brandt, J., E. Srour, K. van Besien, R. A. Bridell, and R. Hoffman. 1990. Cytokine-dependent long-term culture of highly enriched hematopoietic progenitor cells from human bone marrow. J. Clin. Invest. 86:932-941.
27. Verfaillie, C., and P. B. McGlave. 1991. Leukemia inhibitory factor/ human interleukin for DA cells: a growth factor that stimulates the in vitro development of multipotential human hemopoietic progenitors. Blood. 77:263-270.
28. Dewald, G. W., Broderick, D. J., Tom, W. T., Hagstrom, J. E., and Pierre, R. V. 1984. The effectiveness of direct, 24-hour culture, and mitotic synchronization methods for cytogenetic analysis of bone marrow in neoplastic hematologic disorders. Cancer Genet. Cytogenet. 18:1-10.
29. Tanaka, Y., D. H. Adams, S. Hubscher, H. Hirano, U. Siebenlist, and S. Shaw. 1993. T cell adhesion induced by proteoglycan immobilized cytokine MIP-1β. Nature (Lond.). 361:79-82.
30. Rot, A. 1992. Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration. Immunol. Today. 13:291-294.
31. Plumb, M., G. Graham, M. Grove, A. Reid, and I. B. Pragnell. 1991. Molecular aspects of a negative regulator of haematopoiesis. Br. J. Cancer. 64:990-992.
32. Neote, K., D. DeGregorio, J. Mak, R. Horuk, and T. J. Shall. 1993. Molecular cloning, functional expression and signaling characteristics of a C-C chemokine receptor. Cell. 72:415-425.
33. Sham, R. L., P. D. Phatak, T. P. Ihne, C. N. Abboud, and C. H. Packman. 1993. Signal pathway regulation of interleukin-8 induced actin polymerization in neutrophils. Blood. 82:2546-2551.
34. Migas, J., R. Hurley, and C. M. Verfaillie. 1994. MIP-1α and TGF-β increase adhesion of normal committed progenitors to marrow stroma. Exp. Hematol. 22 (8):736A.
35. Hynes, R. O. 1992. Integrins: versatility, modulation and signaling in cell adhesion. Cell. 69:11-25.
36. Burridge, K., K. Path, T. Kelley, G. Nuckolls, and C. Turner. Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Ann. Rev. Cell Biol. 4:487-525.
37. Horwitz, A., K. Duggan, C. Buck, M. C. Beckerle, and K. Burridge. 1986. Interaction of plasma membrane fibronectin receptor with talin: a transmembrane linkage. Nature (Lond.). 320:531-533.
38. Otey, C. A., F. M. Pvalka, and K. Burridge. 1990. An interaction between α-actinin and the β1 subunit in vitro. J. Cell Biol. 111:721-729.
39. Komberg L., H. S. Earp, J. T. Parsons, M. Schaller, and R. L. Juliano. 1992. Cell adhesion or integrin clustering increases phosphorylation of focal adhesion-associated tyrosine kinase. J. Biol. Chem. 267:23439-23442.
40. McWhirter, J. R., and J. Y. J. Wang. 1993. An actin-binding function contributes to transformation by the bcr-abl oncoprotein of Philadelphia chromosome-positive human leukemias. EMBO (Eur. Mol. Biol. Org.) J. 12:1533-1546.
41. Wetzler, M., M. Talpaz, R. A. van Etten, C. Hirsh-Ginsberg, M. Beran, and R. Kurzrock. 1993. Subcellular localization of Bcr, Abl and Bcr-abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation. J. Clin. Invest. 92:1925-1939.
42. Horvath, A. R., M. A. Elmore, and S. Kellie 1990. Differential tyrosine specific phosphorylation of integrin in Rous sarcoma transformed cells with differing transformed phenotype. Oncogene. 5:1349-1357.
43. Matsulonis, U., R. Salgia, K. Okuda, B. Druker, and J. D. Griffin. 1993. Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent myeloid cell line. Exp. Hematol. 21:1460-1466.
44. Bhatia, R., and C. M. Verfaillie. 1994. Interferon-α restores normal negative regulation of CML progenitor proliferation by the marrow microenvironment. Blood. 84:517. (Abstr.)
45. Eaves, C. J., J. D. Cashman, S. D. Wolpe, and A. C. Eaves. 1993. Unresponsiveness of primitive chronic myelogenous leukemia cells to macrophage inflammatory protein 1α, an inhibitor of primitive normal hematopoietic cells. Proc. Natl. Acad. Sci. USA. 90:12015-12019.
46. Hurley, R. W., J. B. McCarthy, E. A. Wayner, and C. M. Verfaillie. 1994. Monoclonal antibody induced clustering of the alpha-4 integrin inhibits hematopoietic progenitor proliferation. Exp. Hematol. 22:335. (Abstr.)
47. Klemke, R. L., M. Yebra, E. M. Bayna, and D. A. Cheresh. 1994. Receptor tyrosine kinase signalling required for integrin αvβ5-directed cell motility but not adhesion on vitronectin. J. Cell Biol. 127:859-866.
48. Bhatia R., P. B. McGlave, and C. M. Verfaillie. 1994. Interferon-α treatment of marrow stroma results in enhanced adhesion of chronic myelogenous leukemia progenitors via mechanisms involving MIP-1α and TGF-β. Exp. Hematol. 22(8):797A.