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1
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0021818675
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Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface
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(1985)
Science
, vol.228
, pp. 1315-1317
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Smith1
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6
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0028277928
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High-affinity urokinase receptor antagonists identified with bacteriophage peptide display
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This paper presents an ingenious strategy for biopanning membrane receptors on intact cells. The receptor is expressed on the surface of two distinctly different cell lines. Rounds of biopanning are alternated between the two cell lines, thus negating the background of phage binding to other cell-surface receptors. of special interest
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(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 7129-7133
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Goodson1
Doyle2
Kaufman3
Rosenberg4
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7
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0027997708
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The characterization of p53 binding phage isolated from phage peptide display libraries
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(1994)
J Mol Biol
, vol.243
, pp. 639-652
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Daniels1
Lane2
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8
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0027946232
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Isolation of a peptide antagonist to the thrombin receptor using phage display
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(1994)
J Mol Biol
, vol.244
, pp. 361-369
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Doorbar1
Winter2
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9
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0027976103
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1 integrin from a phage display library
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One of the difficulties in identifying integrin-specific ligands is often the overlap in binding affinities for various peptide ligands. This report describes a method for minimizing cross-reactivity by including integrins with similar binding characteristics as soluble competitors during biopanning experiments. of special interest
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(1994)
The Journal of Cell Biology
, vol.124
, pp. 373-380
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Koivunen1
Wang2
Ruoslahti3
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10
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0028899525
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Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-directed integrins
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(1995)
Biotechnology
, vol.13
, pp. 265-270
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Koivunen1
Wang2
Ruoslahti3
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11
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0028333754
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Synthetic peptide ligands of the antigen binding receptor induce programmed cell death in a human B-cell lymphoma
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The authors describe the identification of a peptide that binds B-cell lymphoma. As many cells undergo apoptosis when cross-linked, the authors show that the identified binding peptides, when chemically synthesized and cross-linked, induce apoptosis. of special interest
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(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 3623-3627
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Renschler1
Bhatt2
Dower3
Levy4
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14
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0028304495
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Identification of a structural epitope by using a peptide library displayed on filamentous bacteriophage
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(1994)
J Immunol
, vol.22
, pp. 724-729
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Hoess1
Mack2
Walton3
Reilly4
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19
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0028239263
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Production of an atrial natriuretic peptide variant that is specific for type A receptor
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This paper demonstrates that it is possible to produce atrial natriuretic peptide to obtain a variant with high affinity for the type A receptor and significantly lower affinity for type N receptor., of special interest
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(1994)
EMBO J
, vol.13
, pp. 2508-2515
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Cunningham1
Lowe2
Li3
Bennett4
Wells5
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21
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0028357160
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Cell binding and internalization by filamentous phage displaying a cyclic Arg-Gly-Asp-containing peptide
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Demonstration that a constrained ArgGlyAsp peptide tethered to phage coat protein gVIII can result in selective uptake of phage by Hep-2 cells. This work suggests that surface display may be useful in the construction of gene delivery vehicles. of special interest
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(1994)
J Biol Chem
, vol.269
, pp. 12468-12474
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Hart1
Knight2
Harbottle3
Mistry4
Hunger5
Cutler6
Williamson7
Coutelle8
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25
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0028291823
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Isolation of high affinity human antibodies directly from large synthetic repertoires
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This paper details the construction of very large repertoires of antibodies using natural antibodies, polymerase chain reaction mutagenesis and in vivo chain shuffling by site-specific recombination. This probably represents the largest in vitro repertoire built to date, with an impressive success rate for identifying antibodies of nanomolar affinity to a wide variety of antigens. of special interest
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(1994)
EMBO J
, vol.13
, pp. 3245-3260
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Griffiths1
Williams2
Hartley3
Tomlinson4
Waterhouse5
Crosby6
Kontermann7
Jones8
Low9
Allison10
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26
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0028592565
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A new phage display system to construct multicombinatorial libraries of very large antibody repertoires
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(1994)
Gene
, vol.151
, pp. 109-113
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Geoffroy1
Sodoyer2
Aujame3
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30
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0028568028
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Building synthetic antibodies as adhesive ligands for integrins
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This paper describes an example of affinity maturation of antibodies via mutagenesis of specific complementarity-determining region (CDR) loops to obtain antibodies specific for integrin receptors. Using the scaffold of a previously selected antibody, libraries were built in one CDR loop predicted to be essential for high-affinity binding. After several rounds of selection, antibodies were selected that were specific for closely related integrins. of special interest
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(1994)
J Biol Chem
, vol.269
, pp. 32788-32795
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Smith1
Hu2
Satterthwait3
Pinz-Sweeney4
Barbas5
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34
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0028085530
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Kunitz domain inhibitors of tissue factor-factor VIIa. I. Potent inhibitors selected from libraries by phage display.
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(1994)
J Biol Chem
, vol.269
, pp. 22129-22136
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Dennis1
Lazarus2
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35
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0028100458
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Kunitz domain inhibitors of tissue factor-factor VIIa. II. Potent and specific inhibitors by competitive phage selection
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(1994)
J Biol Chem
, vol.269
, pp. 22137-22144
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Dennis1
Lazarus2
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36
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0028328872
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Zinc finger phage: affinity selection of fingers with new DNA-binding specificities
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(1994)
Science
, vol.263
, pp. 671-673
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Rebar1
Pabo2
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39
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0027994717
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Toward a code for the interactions of zinc fingers with DNA: selection of randomized fingers displayed on phage
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(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 11163-11167
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Choo1
Klug2
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40
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0028046895
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Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions.
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This paper describes an excellent systematic analysis of zinc finger DNA-binding specificities based on phage display. This illustrates the detailed information that can be obtained directly from phage without resorting to peptide synthesis. An instant classic! of outstanding interest
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(1994)
Proceedings of the National Academy of Sciences
, vol.91
, pp. 11168-11172
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Choo1
Klug2
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41
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0028670569
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In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence
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This paper represents the crucial test for experiments in which new DNA-binding specificities of zinc fingers have been selected. The question is will these constructs work in vivo? The answer is supplied in this paper: newly designed zinc fingers are tested in vivo and shown to block transcription. of outstanding interest
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(1994)
Nature
, vol.372
, pp. 642-645
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Choo1
Sanchez-Garcia2
Klug3
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42
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0028821194
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Thermodynamic genetics of the folding of the B1-immunoglobulin binding domain from streptococcal protein G
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Reports the display of the B1 domain of protein G on phage and the isolation of mutants that destabilize the protein. Careful physical analysis of the mutants provides a thermodynamic scale for proteins that are still able to bind IgG but are structurally destabilized. of special interest
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(1995)
Proteins
, vol.21
, pp. 11-21
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O'Neil1
Hoess2
Raleigh3
DeGrado4
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49
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0028942281
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Surface expression and ligand-based selection of cDNAs fused to filamentous phage gene VI
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Reports another phage M13 protein, gVI, that can be used for display. The unique feature is that C-terminal fusions are made to this protein, making it ideal for construction of cDNA libraries. These authors have expressed and successfully biopanned a cDNA library from Ancylostoma caninum. of special interest
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(1995)
Biotechnology
, vol.13
, pp. 378-382
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Jespers1
Messens2
De Keyser3
Eeckhout4
Van Den Brande5
Gansemans6
Lauwereys7
Vlasuk8
Stanssens9
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50
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0028168581
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λfoo: A λ phage vector for the expression of foreign proteins
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This is the first demonstration of proteins on the surface of phage λ displayed as a result of C-terminal fusions to the tail protein V. As secretion is not required in this system, intracellular multimeric proteins can easily be displayed on the phage. of special interest
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(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 8273-8277
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Maruyama1
Maruyama2
Brenner3
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52
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0028308297
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Membrane insertion defects caused by positive charges in the early mature region of protein pIII of filamentous phage fd can be corrected by prlA suppressors
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(1994)
J Bacteriol
, vol.176
, pp. 4296-4305
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Peters1
Schatz2
Johnson3
Dower4
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53
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0027933750
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Clonal selection and amplification of phage displayed antibodies by linking antigen recognition and phage replication
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This paper describes a semi in vitro system for selection of phage by fusing the target protein to gIII. Binding of phage to the fusion protein allows for productive infection of the E. coli host. of special interest
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(1994)
Biotechnology
, vol.12
, pp. 999-1002
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Duenas1
Borrebaeck2
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54
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0028670306
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Direct interaction rescue, a novel filamentous phage technique to study protein—protein interactions
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These authors demonstrate that the method described in [53] can be used to isolate relevant clones from an expressed cDNA library. This paper and [53] represent a complementary approach to the yeast two-hybrid system. of special interest
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(1994)
Nucleic Acids Res
, vol.22
, pp. 5761-5762
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Gramatikoff1
Georgiev2
Schaffner3
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