Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers

FASEB Journal

Volumn 9, Issue 10, 1995, Pages 899-909

  Collins, Tucker ^a,c   Read, Margaret A ^a   Neish, Andrew S ^a   Whttley, Maryann Z ^a   Thanos, Dimitris ^b,d   Maniatis, Tom ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

cytokine; endothelium; enhancer; gene expression

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

GENE EXPRESSION REGULATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INDUCTION; REGULATORY MECHANISM; REVIEW; TRANSCRIPTION REGULATION;

EID: 0029101772     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.9.10.7542214     Document Type: Review

References (72)

1. Springer, T. (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76, 301-314
2. Carlos, T. M., and Harlan, J. M. (1994) Lcukocyte-endothelial adhesion molecules. Blood 84, 2068-2101
3. Grilli, M., Chiu, J.-S., and Lenardo, M. (1993) NF-κB and Rel, participants in a multiform transcriptional regulatory system. In International Review of Cytology. A Survey of Cell Biology, pp. 1-62, Academic Press, San Diego, California
4. Beg, A. A., and Baldwin, A. S. (1993) The IκB proteins: multifunctional regulators of Rel/NFκB transcription factors. Genes Dev. 7, 2064-2070
5. Thompson, J. E., Phillips, R. J., Erdjument-Bromage, H., Tempst, P., and Ghosh, S. (1995) IκB-β regulates the persistent response in a biphasic activation of NF-κB. Cell, 80, 573-582
6. Thanos, D., and Maniatis, T. (1995) NF-κB: a lesson in family values. Cell. 80, 529-532
7. Miyamoto, Sh., Maki, M., Schmitt, M. J., Hatanaka, M., and Verma, I. M. (1994) Tumor necrosis factor α-induced phosphorylation of IκBα is a signal for its degradation but not dissociation from NF-κB. Proc. Natl. Acad. Sci. USA 91, 12740-12744
8. Finco, T. S., Beg, A. A., and Baldwin, A. S., Jr. (1994) Inducible phosphorylation of IκB is not sufficient for its dissociation from NF-κB and is inhibited by protease inhibitors. Proc. Natl. Acad. Sci. USA 91, 11884-11888
9. Palombella, V. J., Rando, O. J., Goldberg, A. L., and Maniatis, T. (1994) The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78, 773-785
10. Traenckner, E. B.-M., Wilk, S., and Baeuerle, P. A. (1994) A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB. EMBO J. 13, 5433-5441
11. Brown, K., Park, S., Kanno, T., Franzoso, G., and Siebenlist, U. (1993) Mutual regulation of the transcriptional activator NF-κB and its inhibitor, IκBα. Proc. Natl. Acad. Sci. USA 90, 2532-2536
12. Sun, S.-C., Ganchi, P., Ballard, D., and Greene, W. (1993) NF-κB controls expression of inhibitor IκBα: evidence for an inducible autoregulatory pathway. Science 259, 1912-1915
13. Scott, M. L., Fujita, T., Liou, H.-C., Nolan, G. P., and Baltimore, D. (1993) The p65 subunit of NF-κB regulates 1κB by two distinct mechanisms. Genes Dev. 7, 1266-1276
14. de Martin, R., Vanhove, B., Cheng, Q., Hofer, E., Csizmadia, V., Winkler, H., and Bach, F. H. (1993) Cytokine-inducible expression in endothelial cells of an IκBα-like gene is regulated by NF-κB. EMBO J. 12, 2773-2779
15. Collins, T. (1993) Endothelial nuclear factor-κB and the initiation of the atherosclerotic lesion. Lab. Invest. 5, 499-508
16. Collins, T., Palmer, H. J., Whitley, M. Z., Neish, A. S., and Williams A. J. (1993) A common theme in endothelial activation. Trends Cardiovasc. Med. 3, 92-97
17. Read, M. A., Whitley, M. Z., Williams, A. J., and Collins, T. (1994) NFκB and IκB-α: An inducible regulatory system in endothelial activation. J. Exp. Med. 179, 503-512
18. Resnick, N., and Gimbrone, M. A., Jr. (1995) Hemodynamic forces are complex regulators of endothelial gene expression. FASEB J. 9, 874-882
19. Offermann, M. K., and Medford, R. M. (1994) Antioxidants and atherosclerosis: a molecular perspective. Heart Dis. and Stroke 3, 52-57
20. Read M. A., Neish, A. S., Luscinskas, F. W., Palombella, V. J., Maniatis, T., and Collins, T. (1995) The proteasome pathway is required for cytokine-induced endothelial leukocyte adhesion molecule expression. Immunity 2, 493-506
21. Read, M. A., Neish, A. S., Gerritsen, M. E., and Collins, T. (1995) Nuclear IκB-α and the post-induction transcriptional repression of the E-selectin and VCAM-1 genes. FASEB J. 9, A126 (abstr.)
22. Rice, N. R., and Ernst, M. K. (1993) In vivo control of NF-κB and activation by IκBα. EMBO J. 12, 4685-4695
23. Lewis, H., Kaszubska, W., DeLamarter, J. F., and Whelan, J. (1994) Cooperativity between two NF-κB complexes, mediated by high-mobility-group protein I(Y), is essential for cytokine-induced expression of the E-selectin promoter. Mol. Cell. Biol. 14, 5701-5709
24. Schindler, U., and Baichwal, V. R. (1994) Three NF-κB binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression. Mol. Cell. Biol. 14, 5820-5831
25. Whitley, M.Z., Thanos, D., Read, M. A.- Maniats, T., and Collins, T. (1994) A striking similarity in the organization of the E-selectin and beta Interferon gene promoters. Mol. Cell. Biol. 14, 6464-6475
26. Neish, A. S., Read, M. A., Thanos, D., Pine, R., Maniatis, T., and Collins, T. (1995) Endothelial IRF-1 cooperates with NF-κ as a transcriptional activator of vascular cell adhesion molecule-1. Mol. Cell. Biol. 15, 2558-2569
27. Hou, J., Baichwal, V., and Cao, Z. (1994) Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding ICAM-1. Proc. Natl. Acad. Sci. USA 91, 1641-11645
28. Jahnke, A., Johnson, J. P. (1994) Synergistic activation of intercellular adhesion molecule 1 (ICAM-1) by TNFα and IFN-γ is mediated by p65/p50 and p65/c-Rel and interferon-responsive factor Stat 1α (p91) that can be activated by both IFN-γ and IFN-α. FEBS Lett. 354, 220-226
29. Parry, C. C., and Mackman, N. (1994) A set of inducible genes expressed by activated human monocytic and endothelial cells contain κB-like sites that specifically bind c-Rel-p65 heterodimers. J. Biol. Chem. 269, 20823-20825
30. Mackman, N. (1995) Regulation of the tissue factor gene. FASEB J. 9, 883-889
31. Peters, J. M. (1994) Proteasomes: protein degradation machines of the cell. Trends Biochem. Sci. 19, 377-382
32. Ciechanover, A. (1994) The ubiquitin-proteasome proteolytic pathway. Cell 79, 13-21
33. Rock, K. L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D., and Goldberg, A. L. (1994) Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78, 761-771
34. Cheng, Q., Cant, C. A., Moll, T., Hofer-Warbinek, R., Wagner, E., Birnstiel, M. L., Bach, F. H., and de Martin, R. (1994) NF-κB subunit-specific regulation of the IκBα promoter. J. Biol. Chem. 269, 13551-13557
35. Tedder, T. F., Steeber, D. A., Chen, A., and Engel, P. (1995) The selectins: vascular adhesion molecules. FASEB J. 9, 866-873
36. Bevilacqua, M. P., Stengelin, S., Gimbrone, M. A., Jr., and Seed, B. (1989) Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 243, 1160-1165
37. Collins, T., Williams, A., Johnson, G. I., Kim, J., Eddy, R., Shows, T., Gimbrone, M. A., Jr., and Bevilaqua, M. P. (1991) Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1. J. Biol. Chem. 266, 2466-2473
38. Whelan, J., Ghersa, P., Hooft van Huijsduijnen, R., Gray, J., Chandra, G. Talabot, F., and DeLamarter, J. F. (1991) An NF-κB-like factor is essential but not sufficient for cytokine induction of endothetial adhesion molecule 1 (ELAM-1) gene transcription. Nucleic Acids. Res. 19, 2645-2653
39. Smith, G. M., Whelan, J., Pescini R., Ghersa, P., DeLamarter, J. F., and van Huijsduijnen, R. H. (1993) DNA-methylation of the E-selectin promoter represses NF-κB transactivation. Biochem. Biophys. Res. Commun. 194, 215-221
40. Lamb, P., and McKnight, S. L., (1991) Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization. Trends Biochem. Sci. 16, 417-422
41. Kaszubska, W., Hooft van Huijsduijnen, R., Ghersa, P., DeRaemy-Schenk, A.-M., Chen, B. P. C., Hai,T., DeLamarter, J. F., and Whelan, J. (1993) Cyclic AMP-independent ATF family members interact with NF-κB and function in the activation of the E-selcctin promoter in response to cytokines. Mol. Cell. Biol. 13, 7180-7190
42. Becker-André, M., Hooft van Huijsduijnen, R., Losberger, C., Whelan, J., and DeLamarter, J. F. (1992) Murine endothelial leukocyte-adhesion molecule 1 is a close structural and functional homologue of the human protein. Eur. J. Biochem. 206, 401-411
43. De Luca, L. G., Johnson, D. R., Whitley, M. Z., Collins, T., and Pober, J. S. (1994) cAMP and tumor necrosis factor competitively regulate transcriptional activation through and nuclear factor binding to the cAMP-responsive element/activating transcription factor element of the enothelial leukocyte adhesion molecule-1 (E-selectin) promoter. J. Biol. Chem. 269, 19193-19196
44. Thanos, D., and Maniatis, T. (1992) The high mobility group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene. Cell 71, 777-89
45. Gupta, S., Campbell, D., Derijard, B., Davis R. J. (1995) Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267, 389-393
46. Osborn, L., Hession, C., Tizard, R., Vassallo, C., Luhowskyj, S., Chi-Rosso, G., and Lobb, R. (1989) Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell 59, 1203-1211
47. Elices, M., Osborn, L., Takada, Y., Crouse, C., Luhowskyj, S., Hemler, M., and Lobb, R. (1990) VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 60, 577-584
48. Cybulsky, M., and Gimbrone, M. (1991) Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251, 788-791
49. Pober, J. S., and Cotran, R. C. (1990) Cytokines and endothelial cell biology. Physiol. Rev. 70, 427-451
50. Cybulsky, M., Fries, J., Williams, A., Sultan, P., Eddy, R., Byere, M., Shows, T., Gimbrone, M., and Collins, T. (1991) Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene. Proc. Natl. Acad. Sci. USA 88, 7859-7863
51. Neish, A. S., Williams, A. J., Palmer, H. J., Whitley, M. Z., and Collins, T. (1992) Functional analysis of the human vascular cell adhesion molecule 1 promoter. J. Exp. Med. 176, 1583-1593
52. Shu, H. B., Agranoff, A. B., Nabel, E. G., Leung, K., Duckett, C. S., Neish, A. S., Collins, T., and Nabel, G. (1993) Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-κB subunits in endothelial and epithelial cells. Mol. Cell. Biol. 13, 6283-6289
53. Takeuchi, M., and Baichwal, V. R. (1995) Tumor necrosis factor-alpha induction of MAdCAM-1 gene is mediated by NF-κB proteins. Proc. Natl. Acad. Sci. 92, 3561-3565
54. Mansky, P., Brown, W. M., Park, J.-H., Choi, J. W., and Yang, S. Y. (1994) The second κB element, κB2, of the HLA-a class I regulatory complex is an essential part of the promoter. J. Immunol. 153, 5082-5090
55. Wertheimer, S. J., Myers, C. L., Wallace, R. W., and Parks, T. P. (1992) Intercellular adhesion molecule-1 gene expression in human endothelial cells. J. Biol. Chem. 267, 12030-12035
56. Degitz, K., Lian-Jie, L., and Caughman, S. W. (1991) Cloning and characterization of the 5′-transcriptional regulatory region of the human intercellular adhesion molecule 1 gene. J. Biol. Chem. 266, 14024-14030
57. Voraberger, G., Schafer, R., and Stratowa, C. (1991) Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5′-regulatory region: induction by cytokines and phorbol ester. J. Immunol. 147, 2777-2786
58. Ledebur, H. C., and Parks, T. P. (1995) Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. J. Biol. Chem. 270, 933-943
59. Stein, B., Cogswell P. C., and Baldwin, A. S. (1993) Functional and physical assocations between NF-κB and C/EBP family members: a Rel domain-bZIP interaction. Mol. Cell. Biol. 13, 3964-3974
60. Darnell, J. E., Kerr, I. M., and Stark, G. R. (1994) Jak-STAT pathways and transcriptional activtion in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421
61. Maniatis, T., Whittemore, L. A., Du, W., Fan, C. M., Keller, A., Palombella, V., and Thanos, D. (1992) Positive and negative control of human interferon-β gene expression. In Transcriptional Regulation (McKnight, S. L., and Yamamoto, K., eds) Part 2, pp. 1193-1220, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
62. Thanos, D., Du, W., and Maniatis, T. (1995) The high mobility group protein HMG I(Y) is an essential structural component of a virus-inducible enhancer complex. Cold Spring Harbor Symposia on Quantitative Biology, Vol. LVIII, Cold Spring Harbor Laboratory Press (In press)
63. Bustin, M., Lehn, D., and Landsman, D. (1990) Structural features of HMG chromosomal proteins and their genes. Biochim. Biophys. Acta 109, 231-243
64. Du, W., Thanos, D., and Maniatis, T. (1993) Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell 74, 887-898
65. Meacock, S., Pescini-Gobert, R., DeLamarter, J. F., and van Huijsduijnen, R. H. (1994) Transcription factor-induced, phased bending of the E-selectin promoter. J. Biol. Chem. 269, 31756-31762
66. Tjian, R., and Maniatis, T. (1994) Transcriptional activation: a complex puzzle with few easy pieces. Cell 77, 5-8
67. Muller, C. W., Key, F. A., Sodeoka, M., Verdine, G. L., and Harrison, S. G. (1995) Structure of the NF-κB p50 homodimer bound to DNA. Nature 373, 311-317
68. Ghosh G., van Duyne G., Ghosh, S., and Sigler P. B. (1995) Structure of NF-κB p50 homodimer bound to a κB site. Nature 373, 303-310
69. Kerr, L. D., Ransone, L. J., Wamsley, P., Schmitt, M. J., Boyer, T. G., Zhou, Q., Berk, A. J., and Verma, I. J. (1993) Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB. Nature 365, 412-419
70. Du, W., and Maniatis, T. (1994) The high mobility group protein HMG I(Y) can stimulate or inhibit the binding of distinct transcription factor ATF-2 isoforms to the interferon-β gene promoter. Proc. Natl. Acad. Sci. USA 91, 11318-11322
71. Perkins, N. D., Edwards N. L., Duckett C. S., Agranoff, A. B., Schmid, R. M., and Nabel, G. J. (1993) A cooperative interaction between NF-κB and Sp1 is required for HIV-1 enhancer activation. EMBO J. 12, 3551-3558
72. Gimbrone, M. A., Jr. (1995) Vascular endothelium in health and disease. In Molecular Cardiovascular Medicine, Scientific American Medicine, New York, In press